Effect of red onion (Allium Cepa Var. Aggregatum G. Don) on serum uric acid Level and total antioxidant status in normal and induced hyperuricemic rats
This study aimed to investigate the effect of onion (Allium cepa var. aggregatum G. Don) on serum uric acid level and total antioxidant status of normal and induced hyperuricemic rats.A total of 36 male Sprague-Dawley rats were divided equally into six groups, and 250 mg/kg of potassium oxonate was...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Innovare Academic Sciences Pvt Ltd
2018
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| Subjects: | |
| Online Access: | http://eprints.uthm.edu.my/4950/ http://eprints.uthm.edu.my/4950/1/AJ%202018%20%28150%29.pdf |
| Summary: | This study aimed to investigate the effect of onion (Allium cepa var. aggregatum G. Don) on serum uric acid level and total antioxidant status of normal and induced hyperuricemic rats.A total of 36 male Sprague-Dawley rats were divided equally into six groups, and 250 mg/kg of potassium oxonate was injected
intraperitoneally on day 1, 3, and 7 to induce hyperuricemia in rats. 7 d consecutively of treatment were given to the rats by oral gavage. Serum uric
acid level was measured 2 h after the induction on day 1, 3, 7, and 14. Blood plasma was obtained at day 14 to measure its total antioxidant status. The
rats were sacrificed by taking out their liver and kidney for histopathological evaluation.The results showed that onion juice lowered the serum uric acid level in dose-dependent manner. The highest dose (10.5g/kg/day) appeared
to possess the inhibitory effect almost similar to allopurinol. There was an increase in total antioxidant status in a hyperuricemic group treated with
onion juice compared to control groups but insignificant. By viewing the histological profile, onion showed to have a protective effect toward the liver
damage by hyperuricemia. However, this was not happened in kidney. Onion lowered the serum uric acid level, but its protective effect toward liver and kidney remained ambiguous. Further investigation with
the increase of parameters and inclusion of analytical test of bioactive compound in red onion is recommended for the future studies |
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