Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite
This work reports the surface modification of 3D printed PLA scaffold with chitosan and its hydroxyapatite (HA) forming capability. PLA scaffold was fabricated using a desktop 3D printer followed by the inclusion of chitosan on the surface via surface entrapment. Confocal laser scanning microscopy (...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018
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| Online Access: | http://eprints.uthm.edu.my/4476/ http://eprints.uthm.edu.my/4476/1/AJ%202018%20%28773%29%20Surface%20entrapment%20of%20chitosan%20on%203D%20printed%20polylactic%20acid%20scaffold%20and%20its%20biomimetic%20growth%20of%20hydroxyapatite.pdf |
| _version_ | 1848888297865084928 |
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| author | Jian, Wang Zakaria, Nor Hidayah Abd Razak, Saiful Izwan Abdul Kadir, Mohammed Rafiq Mat Nayan, Nadirul Hasraf Li, Yi Mat Amin, Khairul Anuar |
| author_facet | Jian, Wang Zakaria, Nor Hidayah Abd Razak, Saiful Izwan Abdul Kadir, Mohammed Rafiq Mat Nayan, Nadirul Hasraf Li, Yi Mat Amin, Khairul Anuar |
| author_sort | Jian, Wang |
| building | UTHM Institutional Repository |
| collection | Online Access |
| description | This work reports the surface modification of 3D printed PLA scaffold with chitosan and its hydroxyapatite (HA) forming capability. PLA scaffold was fabricated using a desktop 3D printer followed by the inclusion of chitosan on the surface via surface entrapment. Confocal laser scanning microscopy (CLSM) images showed existence of chitosan entrapment with depth of 24 μm. Immersion of the modified PLA scaffold in simulated body fluid resulted in formation of apatite layers on the surface. Plus the entrapment method does not induce any cytotoxic response towards human fibroblast cell. This method provides a facile approach of obtaining 3D printed scaffold with good bioactivity thus has potential in biomimetic and tissue engineering. |
| first_indexed | 2025-11-15T20:08:03Z |
| format | Article |
| id | uthm-4476 |
| institution | Universiti Tun Hussein Onn Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T20:08:03Z |
| publishDate | 2018 |
| publisher | Taylor & Francis Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | uthm-44762021-12-07T03:58:50Z http://eprints.uthm.edu.my/4476/ Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite Jian, Wang Zakaria, Nor Hidayah Abd Razak, Saiful Izwan Abdul Kadir, Mohammed Rafiq Mat Nayan, Nadirul Hasraf Li, Yi Mat Amin, Khairul Anuar TP200-248 Chemicals: Manufacture, use, etc. This work reports the surface modification of 3D printed PLA scaffold with chitosan and its hydroxyapatite (HA) forming capability. PLA scaffold was fabricated using a desktop 3D printer followed by the inclusion of chitosan on the surface via surface entrapment. Confocal laser scanning microscopy (CLSM) images showed existence of chitosan entrapment with depth of 24 μm. Immersion of the modified PLA scaffold in simulated body fluid resulted in formation of apatite layers on the surface. Plus the entrapment method does not induce any cytotoxic response towards human fibroblast cell. This method provides a facile approach of obtaining 3D printed scaffold with good bioactivity thus has potential in biomimetic and tissue engineering. Taylor & Francis Group 2018 Article PeerReviewed text en http://eprints.uthm.edu.my/4476/1/AJ%202018%20%28773%29%20Surface%20entrapment%20of%20chitosan%20on%203D%20printed%20polylactic%20acid%20scaffold%20and%20its%20biomimetic%20growth%20of%20hydroxyapatite.pdf Jian, Wang and Zakaria, Nor Hidayah and Abd Razak, Saiful Izwan and Abdul Kadir, Mohammed Rafiq and Mat Nayan, Nadirul Hasraf and Li, Yi and Mat Amin, Khairul Anuar (2018) Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite. Composite Interfaces, 26 (2011). 0927-6440. ISSN 0927-6440 |
| spellingShingle | TP200-248 Chemicals: Manufacture, use, etc. Jian, Wang Zakaria, Nor Hidayah Abd Razak, Saiful Izwan Abdul Kadir, Mohammed Rafiq Mat Nayan, Nadirul Hasraf Li, Yi Mat Amin, Khairul Anuar Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite |
| title | Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite |
| title_full | Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite |
| title_fullStr | Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite |
| title_full_unstemmed | Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite |
| title_short | Surface entrapment of chitosan on 3D printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite |
| title_sort | surface entrapment of chitosan on 3d printed polylactic acid scaffold and its biomimetic growth of hydroxyapatite |
| topic | TP200-248 Chemicals: Manufacture, use, etc. |
| url | http://eprints.uthm.edu.my/4476/ http://eprints.uthm.edu.my/4476/1/AJ%202018%20%28773%29%20Surface%20entrapment%20of%20chitosan%20on%203D%20printed%20polylactic%20acid%20scaffold%20and%20its%20biomimetic%20growth%20of%20hydroxyapatite.pdf |