Synthesis, characterization and antioxidant activity of 1,2,4-triazole and its Schiff base derivatives
1,2,4-Triazole and its Schiff base derivatives are found to exhibit diverse biological activities which could contribute to medicinal field as novel drugs. The synthesized novel 1,2,4-triazole and its Schiff base compounds were characterized for their antioxidant potential. The 1,2,4-triazole was sy...
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| Format: | Final Year Project / Dissertation / Thesis |
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2023
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| Online Access: | http://eprints.utar.edu.my/6073/ http://eprints.utar.edu.my/6073/1/Wong_Wen__Li.pdf |
| _version_ | 1848886582912745472 |
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| author | Wong, Wen Li |
| author_facet | Wong, Wen Li |
| author_sort | Wong, Wen Li |
| building | UTAR Institutional Repository |
| collection | Online Access |
| description | 1,2,4-Triazole and its Schiff base derivatives are found to exhibit diverse biological activities which could contribute to medicinal field as novel drugs. The synthesized novel 1,2,4-triazole and its Schiff base compounds were characterized for their antioxidant potential. The 1,2,4-triazole was synthesized by fusion reaction between indole-3-acetic acid and thiocarbohydrazide, while the Schiff bases were synthesized from the condensation reaction between 1,2,4-triazole and a series of benzaldehyde derivatives. The compounds were characterized using modern IR and NMR techniques for structure elucidation. The antioxidant activity of the synthesized compounds was determined using DPPH assay with BHT as standard antioxidant. 1,2,4-Triazole and its Schiff bases showed moderate antioxidant activities with IC50 ranged from 40.3 to 176.4 ppm, except for SBs 6, 7, 8, and 14, which showed IC50 more than 200 ppm which exceeded the concentration range prepared for the DPPH assay. |
| first_indexed | 2025-11-15T19:40:48Z |
| format | Final Year Project / Dissertation / Thesis |
| id | utar-6073 |
| institution | Universiti Tunku Abdul Rahman |
| institution_category | Local University |
| last_indexed | 2025-11-15T19:40:48Z |
| publishDate | 2023 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | utar-60732024-01-05T15:24:09Z Synthesis, characterization and antioxidant activity of 1,2,4-triazole and its Schiff base derivatives Wong, Wen Li QD Chemistry 1,2,4-Triazole and its Schiff base derivatives are found to exhibit diverse biological activities which could contribute to medicinal field as novel drugs. The synthesized novel 1,2,4-triazole and its Schiff base compounds were characterized for their antioxidant potential. The 1,2,4-triazole was synthesized by fusion reaction between indole-3-acetic acid and thiocarbohydrazide, while the Schiff bases were synthesized from the condensation reaction between 1,2,4-triazole and a series of benzaldehyde derivatives. The compounds were characterized using modern IR and NMR techniques for structure elucidation. The antioxidant activity of the synthesized compounds was determined using DPPH assay with BHT as standard antioxidant. 1,2,4-Triazole and its Schiff bases showed moderate antioxidant activities with IC50 ranged from 40.3 to 176.4 ppm, except for SBs 6, 7, 8, and 14, which showed IC50 more than 200 ppm which exceeded the concentration range prepared for the DPPH assay. 2023-06 Final Year Project / Dissertation / Thesis NonPeerReviewed application/pdf http://eprints.utar.edu.my/6073/1/Wong_Wen__Li.pdf Wong, Wen Li (2023) Synthesis, characterization and antioxidant activity of 1,2,4-triazole and its Schiff base derivatives. Final Year Project, UTAR. http://eprints.utar.edu.my/6073/ |
| spellingShingle | QD Chemistry Wong, Wen Li Synthesis, characterization and antioxidant activity of 1,2,4-triazole and its Schiff base derivatives |
| title | Synthesis, characterization and antioxidant activity of 1,2,4-triazole and its Schiff base derivatives |
| title_full | Synthesis, characterization and antioxidant activity of 1,2,4-triazole and its Schiff base derivatives |
| title_fullStr | Synthesis, characterization and antioxidant activity of 1,2,4-triazole and its Schiff base derivatives |
| title_full_unstemmed | Synthesis, characterization and antioxidant activity of 1,2,4-triazole and its Schiff base derivatives |
| title_short | Synthesis, characterization and antioxidant activity of 1,2,4-triazole and its Schiff base derivatives |
| title_sort | synthesis, characterization and antioxidant activity of 1,2,4-triazole and its schiff base derivatives |
| topic | QD Chemistry |
| url | http://eprints.utar.edu.my/6073/ http://eprints.utar.edu.my/6073/1/Wong_Wen__Li.pdf |