Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazoles
In this project, a 1,2,4-triazole and eight 1,2,4-triazolo-1,3,4-thiadiazole derivatives have been successfully synthesized and characterized. On the other hand, 1,2,4-triazolo-1,3,4-thiadiazoles were synthesized through refluxing 1,2,4-triazole and benzoic acid derivatives in the presence of phosph...
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| Format: | Final Year Project / Dissertation / Thesis |
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2022
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| Online Access: | http://eprints.utar.edu.my/4924/ http://eprints.utar.edu.my/4924/1/fyp_CE_2022_LXT.pdf |
| _version_ | 1848886278949437440 |
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| author | Loo, Xin Tong |
| author_facet | Loo, Xin Tong |
| author_sort | Loo, Xin Tong |
| building | UTAR Institutional Repository |
| collection | Online Access |
| description | In this project, a 1,2,4-triazole and eight 1,2,4-triazolo-1,3,4-thiadiazole derivatives have been successfully synthesized and characterized. On the other hand, 1,2,4-triazolo-1,3,4-thiadiazoles were synthesized through refluxing 1,2,4-triazole and benzoic acid derivatives in the presence of phosphorous oxychloride as the cyclization agent. The 1,2,4-triazolo-1,3,4-thiadiazole derivatives were named as XT1, XT2, XT3, XT4, XT5, XT6, XT7 and XT8 for different substituents which were H, 4-Cl, 2-Cl, 2,4-Cl2, 3-CF3, 4-CF3, 4-OCH3 and 4-NO2, respectively. The structure of 1,2,4-triazole and 1,2,4-triazolo-1,3,4-thiadiazole derivatives (XT1-XT8) were characterized by FT-IR, 1H NMR, 13C NMR, DEPT, HMQC and HMBC spectroscopies as well as melting point apparatus. The percentage yield of 1,2,4-triazole obtained was 31 % whereas XT1-XT8 were synthesized with the percentage yield in the range of 8 – 69 %. |
| first_indexed | 2025-11-15T19:35:58Z |
| format | Final Year Project / Dissertation / Thesis |
| id | utar-4924 |
| institution | Universiti Tunku Abdul Rahman |
| institution_category | Local University |
| last_indexed | 2025-11-15T19:35:58Z |
| publishDate | 2022 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | utar-49242023-01-05T13:41:54Z Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazoles Loo, Xin Tong QD Chemistry In this project, a 1,2,4-triazole and eight 1,2,4-triazolo-1,3,4-thiadiazole derivatives have been successfully synthesized and characterized. On the other hand, 1,2,4-triazolo-1,3,4-thiadiazoles were synthesized through refluxing 1,2,4-triazole and benzoic acid derivatives in the presence of phosphorous oxychloride as the cyclization agent. The 1,2,4-triazolo-1,3,4-thiadiazole derivatives were named as XT1, XT2, XT3, XT4, XT5, XT6, XT7 and XT8 for different substituents which were H, 4-Cl, 2-Cl, 2,4-Cl2, 3-CF3, 4-CF3, 4-OCH3 and 4-NO2, respectively. The structure of 1,2,4-triazole and 1,2,4-triazolo-1,3,4-thiadiazole derivatives (XT1-XT8) were characterized by FT-IR, 1H NMR, 13C NMR, DEPT, HMQC and HMBC spectroscopies as well as melting point apparatus. The percentage yield of 1,2,4-triazole obtained was 31 % whereas XT1-XT8 were synthesized with the percentage yield in the range of 8 – 69 %. 2022-05 Final Year Project / Dissertation / Thesis NonPeerReviewed application/pdf http://eprints.utar.edu.my/4924/1/fyp_CE_2022_LXT.pdf Loo, Xin Tong (2022) Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazoles. Final Year Project, UTAR. http://eprints.utar.edu.my/4924/ |
| spellingShingle | QD Chemistry Loo, Xin Tong Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazoles |
| title | Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazoles |
| title_full | Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazoles |
| title_fullStr | Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazoles |
| title_full_unstemmed | Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazoles |
| title_short | Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazoles |
| title_sort | synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazoles |
| topic | QD Chemistry |
| url | http://eprints.utar.edu.my/4924/ http://eprints.utar.edu.my/4924/1/fyp_CE_2022_LXT.pdf |