Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives
In this project, a 1,2,4-triazole and a series of 1,2,4-triazolo-1,3,4-thiadiazole derivatives have been successfully synthesized. A total of eight 1,2,4-triazolo-1,3,4-thiadiazole derivatives (YR1-YR8) with different R group substituents (R = H, 2-F, 4-F, 2,4-F2, 4-Br, 4-CH3, 4-N(CH3)2 and 4-NO2) w...
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| Format: | Final Year Project / Dissertation / Thesis |
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2022
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| Online Access: | http://eprints.utar.edu.my/4922/ http://eprints.utar.edu.my/4922/1/fyp_CE_2022_CYR.pdf |
| _version_ | 1848886278409420800 |
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| author | Cheng, Yun Ru |
| author_facet | Cheng, Yun Ru |
| author_sort | Cheng, Yun Ru |
| building | UTAR Institutional Repository |
| collection | Online Access |
| description | In this project, a 1,2,4-triazole and a series of 1,2,4-triazolo-1,3,4-thiadiazole derivatives have been successfully synthesized. A total of eight 1,2,4-triazolo-1,3,4-thiadiazole derivatives (YR1-YR8) with different R group substituents (R = H, 2-F, 4-F, 2,4-F2, 4-Br, 4-CH3, 4-N(CH3)2 and 4-NO2) were synthesized from 1,2,4-triazole and benzoic acid derivatives via condensation reaction in the presence of phosphoryl chloride (POCl3) as cyclization agent. The percentage yield of 1,2,4-triazole was 31 % whereas the percentage yield of the synthesized 1,2,4-triazolo-1,3,4-thiadiazole derivatives (YR1-YR8) was in the range of 7 – 84 %. The structures of 1,2,4-triazole and a series of 1,2,4-triazolo-1,3,4-thiadiazole derivatives (YR1-YR8) were characterized and elucidated by using FTIR, 1H NMR, 13C NMR, DEPT, HMQC, HMBC and melting point apparatus. |
| first_indexed | 2025-11-15T19:35:57Z |
| format | Final Year Project / Dissertation / Thesis |
| id | utar-4922 |
| institution | Universiti Tunku Abdul Rahman |
| institution_category | Local University |
| last_indexed | 2025-11-15T19:35:57Z |
| publishDate | 2022 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | utar-49222022-12-30T14:52:50Z Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives Cheng, Yun Ru QD Chemistry In this project, a 1,2,4-triazole and a series of 1,2,4-triazolo-1,3,4-thiadiazole derivatives have been successfully synthesized. A total of eight 1,2,4-triazolo-1,3,4-thiadiazole derivatives (YR1-YR8) with different R group substituents (R = H, 2-F, 4-F, 2,4-F2, 4-Br, 4-CH3, 4-N(CH3)2 and 4-NO2) were synthesized from 1,2,4-triazole and benzoic acid derivatives via condensation reaction in the presence of phosphoryl chloride (POCl3) as cyclization agent. The percentage yield of 1,2,4-triazole was 31 % whereas the percentage yield of the synthesized 1,2,4-triazolo-1,3,4-thiadiazole derivatives (YR1-YR8) was in the range of 7 – 84 %. The structures of 1,2,4-triazole and a series of 1,2,4-triazolo-1,3,4-thiadiazole derivatives (YR1-YR8) were characterized and elucidated by using FTIR, 1H NMR, 13C NMR, DEPT, HMQC, HMBC and melting point apparatus. 2022-05 Final Year Project / Dissertation / Thesis NonPeerReviewed application/pdf http://eprints.utar.edu.my/4922/1/fyp_CE_2022_CYR.pdf Cheng, Yun Ru (2022) Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives. Final Year Project, UTAR. http://eprints.utar.edu.my/4922/ |
| spellingShingle | QD Chemistry Cheng, Yun Ru Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives |
| title | Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives |
| title_full | Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives |
| title_fullStr | Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives |
| title_full_unstemmed | Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives |
| title_short | Synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives |
| title_sort | synthesis and characterization of 1,2,4-triazolo-1,3,4-thiadiazole derivatives |
| topic | QD Chemistry |
| url | http://eprints.utar.edu.my/4922/ http://eprints.utar.edu.my/4922/1/fyp_CE_2022_CYR.pdf |