Synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety
In this project, an indole ester, carboxyl hydrazide and four new 1,3,4-oxadiazoles derivatives have been successfully synthesized and characterized. The four new 1,3,4-oxadiazoles derivatives were synthesized by the reaction of carboxyl hydrazide and benzoic acid derivatives which being named as JL...
| Main Author: | |
|---|---|
| Format: | Final Year Project / Dissertation / Thesis |
| Published: |
2019
|
| Subjects: | |
| Online Access: | http://eprints.utar.edu.my/3958/ http://eprints.utar.edu.my/3958/1/fyp_CE_2019_CJL.pdf |
| _version_ | 1848886036670709760 |
|---|---|
| author | Chong, Jien Lee |
| author_facet | Chong, Jien Lee |
| author_sort | Chong, Jien Lee |
| building | UTAR Institutional Repository |
| collection | Online Access |
| description | In this project, an indole ester, carboxyl hydrazide and four new 1,3,4-oxadiazoles derivatives have been successfully synthesized and characterized. The four new 1,3,4-oxadiazoles derivatives were synthesized by the reaction of carboxyl hydrazide and benzoic acid derivatives which being named as JL1, JL2 JL3 and JL4 respectively. The structures of carboxyl hydrazide and 1,3,4-oxadiazole derivatives (JL1-JL4) were characterized by 1H NMR, 13C NMR, DEPT, HMQC, HMBC, and IR spectroscopic. The antioxidant activity of carboxyl hydrazide and 1,3,4-oxadiazole derivatives were evaluated by using 2,2-diphenyl-2-picryhydrazyl hydrate (DDPH) radical scavenging assay where the carboxyl hydrazide and 1,3,4- oxadiazole showed weak antioxidant activity. |
| first_indexed | 2025-11-15T19:32:07Z |
| format | Final Year Project / Dissertation / Thesis |
| id | utar-3958 |
| institution | Universiti Tunku Abdul Rahman |
| institution_category | Local University |
| last_indexed | 2025-11-15T19:32:07Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | utar-39582023-01-05T14:31:02Z Synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety Chong, Jien Lee QD Chemistry In this project, an indole ester, carboxyl hydrazide and four new 1,3,4-oxadiazoles derivatives have been successfully synthesized and characterized. The four new 1,3,4-oxadiazoles derivatives were synthesized by the reaction of carboxyl hydrazide and benzoic acid derivatives which being named as JL1, JL2 JL3 and JL4 respectively. The structures of carboxyl hydrazide and 1,3,4-oxadiazole derivatives (JL1-JL4) were characterized by 1H NMR, 13C NMR, DEPT, HMQC, HMBC, and IR spectroscopic. The antioxidant activity of carboxyl hydrazide and 1,3,4-oxadiazole derivatives were evaluated by using 2,2-diphenyl-2-picryhydrazyl hydrate (DDPH) radical scavenging assay where the carboxyl hydrazide and 1,3,4- oxadiazole showed weak antioxidant activity. 2019-09-20 Final Year Project / Dissertation / Thesis NonPeerReviewed application/pdf http://eprints.utar.edu.my/3958/1/fyp_CE_2019_CJL.pdf Chong, Jien Lee (2019) Synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety. Final Year Project, UTAR. http://eprints.utar.edu.my/3958/ |
| spellingShingle | QD Chemistry Chong, Jien Lee Synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety |
| title | Synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety |
| title_full | Synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety |
| title_fullStr | Synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety |
| title_full_unstemmed | Synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety |
| title_short | Synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety |
| title_sort | synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety |
| topic | QD Chemistry |
| url | http://eprints.utar.edu.my/3958/ http://eprints.utar.edu.my/3958/1/fyp_CE_2019_CJL.pdf |