Effect Of Spray-dried Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats.
The objective of this study was to evaluate the effect of commercially prepared spray-dried ethanolic extract ol Andrographis paniculafa (AP) on streptozotocin (STZ)-induced diabetic female rats. METHODOLOGY: Rats with regular estrous cycle (EC) prior to STZ induction were randomly divided into...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
2006
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/8170/ http://eprints.usm.my/8170/1/Effect_of_spray-dried_ethanolic_extract_of_Andrographis_paniculata_%28Burm._F.%29_%28Pusat_Pengajian_Sains_Farmasi%29_2008.pdf |
| Summary: | The objective of this study was to evaluate the effect of
commercially prepared spray-dried ethanolic extract
ol Andrographis paniculafa (AP) on streptozotocin
(STZ)-induced diabetic female rats. METHODOLOGY:
Rats with regular estrous cycle (EC) prior to STZ
induction were randomly divided into five groups. The
normal (nondiabetic) and diabetic controlgroups were
given vehicle [0.2 ml of 2o/o carboxyl methyl cellulose
(CMC) by gavagingl daily for 6 weeks. Other diabetic
groups were treated with 50, 100 and 200 mg/kg/day
of AP extracts respectively. The rats' body weight
(BW), fasting blood glucose and insulin level were
measured; and daily, EC evaluation was perfo;.ry1e.d1
throughout the 6-week study period. At the end.olthe
experiment, rats were sacrificed and their P4fprpases
were removed for histological examination."RESU LTS':,
The survival rates and estrous cycle,'$f''AP-treatbd
diabetic animals were found to be improved compared
to nontreated animals.
|
|---|