Crispr/Cas9-Mediated Suppression Of Dual-Specificity Phosphatase 6 (Dusp6) Inhibits Cell Viability, Growth, Survival And Adhesion In Ht-29 Human Colorectal Cancer Cell Line
Globally, human colorectal adenocarcinoma (CRC) was ranked third and second for the cancer incidence and mortality rate, while in Malaysia, it was ranked second and third for the cancer incidence and mortality rate. Despite its efficacy, the currently available CRC treatment has side effects and com...
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| Format: | Thesis |
| Language: | English |
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2024
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| Online Access: | http://eprints.usm.my/63026/ http://eprints.usm.my/63026/1/Pages%20from%20MUHAMMAD%20KHAIRI%20BIN%20AHMAD%20-%20TESIS.pdf |
| _version_ | 1848885141204631552 |
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| author | Ahmad, Muhammad Khairi |
| author_facet | Ahmad, Muhammad Khairi |
| author_sort | Ahmad, Muhammad Khairi |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Globally, human colorectal adenocarcinoma (CRC) was ranked third and second for the cancer incidence and mortality rate, while in Malaysia, it was ranked second and third for the cancer incidence and mortality rate. Despite its efficacy, the currently available CRC treatment has side effects and complications that compromise the patients’ well-being. Dual-specificity phosphatase 6 (DUSP6), a member of the MAPK phosphatase family, has been identified as pro-oncogenic, tumour-suppressive, or both in many cancers. Nevertheless, its role and significance in the human CRC are poorly studied. Therefore, this research aims to investigate the role and significance of the DUSP6 gene in CRC through modification of its gene expression. |
| first_indexed | 2025-11-15T19:17:53Z |
| format | Thesis |
| id | usm-63026 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T19:17:53Z |
| publishDate | 2024 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-630262025-10-22T00:54:56Z http://eprints.usm.my/63026/ Crispr/Cas9-Mediated Suppression Of Dual-Specificity Phosphatase 6 (Dusp6) Inhibits Cell Viability, Growth, Survival And Adhesion In Ht-29 Human Colorectal Cancer Cell Line Ahmad, Muhammad Khairi R5-920 Medicine (General) Globally, human colorectal adenocarcinoma (CRC) was ranked third and second for the cancer incidence and mortality rate, while in Malaysia, it was ranked second and third for the cancer incidence and mortality rate. Despite its efficacy, the currently available CRC treatment has side effects and complications that compromise the patients’ well-being. Dual-specificity phosphatase 6 (DUSP6), a member of the MAPK phosphatase family, has been identified as pro-oncogenic, tumour-suppressive, or both in many cancers. Nevertheless, its role and significance in the human CRC are poorly studied. Therefore, this research aims to investigate the role and significance of the DUSP6 gene in CRC through modification of its gene expression. 2024-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/63026/1/Pages%20from%20MUHAMMAD%20KHAIRI%20BIN%20AHMAD%20-%20TESIS.pdf Ahmad, Muhammad Khairi (2024) Crispr/Cas9-Mediated Suppression Of Dual-Specificity Phosphatase 6 (Dusp6) Inhibits Cell Viability, Growth, Survival And Adhesion In Ht-29 Human Colorectal Cancer Cell Line. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) Ahmad, Muhammad Khairi Crispr/Cas9-Mediated Suppression Of Dual-Specificity Phosphatase 6 (Dusp6) Inhibits Cell Viability, Growth, Survival And Adhesion In Ht-29 Human Colorectal Cancer Cell Line |
| title | Crispr/Cas9-Mediated Suppression Of Dual-Specificity Phosphatase 6 (Dusp6) Inhibits Cell Viability, Growth, Survival And Adhesion In Ht-29 Human Colorectal Cancer Cell Line |
| title_full | Crispr/Cas9-Mediated Suppression Of Dual-Specificity Phosphatase 6 (Dusp6) Inhibits Cell Viability, Growth, Survival And Adhesion In Ht-29 Human Colorectal Cancer Cell Line |
| title_fullStr | Crispr/Cas9-Mediated Suppression Of Dual-Specificity Phosphatase 6 (Dusp6) Inhibits Cell Viability, Growth, Survival And Adhesion In Ht-29 Human Colorectal Cancer Cell Line |
| title_full_unstemmed | Crispr/Cas9-Mediated Suppression Of Dual-Specificity Phosphatase 6 (Dusp6) Inhibits Cell Viability, Growth, Survival And Adhesion In Ht-29 Human Colorectal Cancer Cell Line |
| title_short | Crispr/Cas9-Mediated Suppression Of Dual-Specificity Phosphatase 6 (Dusp6) Inhibits Cell Viability, Growth, Survival And Adhesion In Ht-29 Human Colorectal Cancer Cell Line |
| title_sort | crispr/cas9-mediated suppression of dual-specificity phosphatase 6 (dusp6) inhibits cell viability, growth, survival and adhesion in ht-29 human colorectal cancer cell line |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/63026/ http://eprints.usm.my/63026/1/Pages%20from%20MUHAMMAD%20KHAIRI%20BIN%20AHMAD%20-%20TESIS.pdf |