Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer
The computational methods of protein-ligand interactions are core components in drug design and modem drug discovery. This study attempted to design and investigate the interactions of new human estrogen receptor (hERa) inhibitors to treat breast cancer cells using molecular modeling approach. The p...
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | http://eprints.usm.my/62857/ http://eprints.usm.my/62857/1/Pages%20from%20Amneh%20Mohammad%20Shtawi.pdf |
| _version_ | 1848885104869376000 |
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| author | Shtaiwi, Amneh Mohammad |
| author_facet | Shtaiwi, Amneh Mohammad |
| author_sort | Shtaiwi, Amneh Mohammad |
| building | USM Institutional Repository |
| collection | Online Access |
| description | The computational methods of protein-ligand interactions are core components in drug design and modem drug discovery. This study attempted to design and investigate the interactions of new human estrogen receptor (hERa) inhibitors to treat breast cancer cells using molecular modeling approach. The proposed inhibitors were designed by replacing the triarylethylene estrogenic scaffold found in the synthetic inhibitor 4-hydroxytamoxifen (4-0HT) with triarylimine Schiff bases. |
| first_indexed | 2025-11-15T19:17:18Z |
| format | Thesis |
| id | usm-62857 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T19:17:18Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-628572025-09-24T02:30:39Z http://eprints.usm.my/62857/ Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer Shtaiwi, Amneh Mohammad QD241-441 Organic chemistry The computational methods of protein-ligand interactions are core components in drug design and modem drug discovery. This study attempted to design and investigate the interactions of new human estrogen receptor (hERa) inhibitors to treat breast cancer cells using molecular modeling approach. The proposed inhibitors were designed by replacing the triarylethylene estrogenic scaffold found in the synthetic inhibitor 4-hydroxytamoxifen (4-0HT) with triarylimine Schiff bases. 2018-10 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/62857/1/Pages%20from%20Amneh%20Mohammad%20Shtawi.pdf Shtaiwi, Amneh Mohammad (2018) Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | QD241-441 Organic chemistry Shtaiwi, Amneh Mohammad Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer |
| title | Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer |
| title_full | Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer |
| title_fullStr | Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer |
| title_full_unstemmed | Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer |
| title_short | Computational Design And Investigation Of New Benzophenones And Benzophenone Imines Inhibitors For Breast Cancer |
| title_sort | computational design and investigation of new benzophenones and benzophenone imines inhibitors for breast cancer |
| topic | QD241-441 Organic chemistry |
| url | http://eprints.usm.my/62857/ http://eprints.usm.my/62857/1/Pages%20from%20Amneh%20Mohammad%20Shtawi.pdf |