Vasorelaxant And Antihypertensive Effects Of 3,4,7,2',4'-Pentahydroxyflavone In In Vitro And In Vivo Models
Hypertension is one of the chronic medical conditions characterised by consistently high blood pressure exerted against the wall of blood vessels. It has emerged as a major global health concern due to its increasing worldwide prevalence. Although numerous antihypertensive medications are available...
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| Format: | Thesis |
| Language: | English |
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2024
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| Online Access: | http://eprints.usm.my/62558/ http://eprints.usm.my/62558/1/TEW%20WAN%20YIN%20-%20TESIS%20cut.pdf |
| _version_ | 1848885021006364672 |
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| author | Wan Yin, Tew |
| author_facet | Wan Yin, Tew |
| author_sort | Wan Yin, Tew |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Hypertension is one of the chronic medical conditions characterised by consistently high blood pressure exerted against the wall of blood vessels. It has emerged as a major global health concern due to its increasing worldwide prevalence. Although numerous antihypertensive medications are available in the market, many are reported to have low efficacy and frequently come with adverse effects or contraindications. Consequently, the current study was designed to identify a potential antihypertensive agent which could avoid all the issues associated with currently market available medications. Morin, a flavonol which was known for its diverse pharmaceutical properties, was selected to evaluate its vasodilatory and antihypertensive activities using in vitro and in vivo approaches, respectively. The vasodilatory effect of morin and its underlying mechanism were evaluated in vitro using aortic rings assay. The results revealed that morin exerts its vasodilatory effects through multiple mechanisms pathways, including endothelium-dependent and endothelium-independent pathways. |
| first_indexed | 2025-11-15T19:15:58Z |
| format | Thesis |
| id | usm-62558 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T19:15:58Z |
| publishDate | 2024 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-625582025-06-24T03:01:42Z http://eprints.usm.my/62558/ Vasorelaxant And Antihypertensive Effects Of 3,4,7,2',4'-Pentahydroxyflavone In In Vitro And In Vivo Models Wan Yin, Tew RS1-441 Pharmacy and materia medica Hypertension is one of the chronic medical conditions characterised by consistently high blood pressure exerted against the wall of blood vessels. It has emerged as a major global health concern due to its increasing worldwide prevalence. Although numerous antihypertensive medications are available in the market, many are reported to have low efficacy and frequently come with adverse effects or contraindications. Consequently, the current study was designed to identify a potential antihypertensive agent which could avoid all the issues associated with currently market available medications. Morin, a flavonol which was known for its diverse pharmaceutical properties, was selected to evaluate its vasodilatory and antihypertensive activities using in vitro and in vivo approaches, respectively. The vasodilatory effect of morin and its underlying mechanism were evaluated in vitro using aortic rings assay. The results revealed that morin exerts its vasodilatory effects through multiple mechanisms pathways, including endothelium-dependent and endothelium-independent pathways. 2024-08 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/62558/1/TEW%20WAN%20YIN%20-%20TESIS%20cut.pdf Wan Yin, Tew (2024) Vasorelaxant And Antihypertensive Effects Of 3,4,7,2',4'-Pentahydroxyflavone In In Vitro And In Vivo Models. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Wan Yin, Tew Vasorelaxant And Antihypertensive Effects Of 3,4,7,2',4'-Pentahydroxyflavone In In Vitro And In Vivo Models |
| title | Vasorelaxant And Antihypertensive Effects Of 3,4,7,2',4'-Pentahydroxyflavone In In Vitro And In Vivo Models |
| title_full | Vasorelaxant And Antihypertensive Effects Of 3,4,7,2',4'-Pentahydroxyflavone In In Vitro And In Vivo Models |
| title_fullStr | Vasorelaxant And Antihypertensive Effects Of 3,4,7,2',4'-Pentahydroxyflavone In In Vitro And In Vivo Models |
| title_full_unstemmed | Vasorelaxant And Antihypertensive Effects Of 3,4,7,2',4'-Pentahydroxyflavone In In Vitro And In Vivo Models |
| title_short | Vasorelaxant And Antihypertensive Effects Of 3,4,7,2',4'-Pentahydroxyflavone In In Vitro And In Vivo Models |
| title_sort | vasorelaxant and antihypertensive effects of 3,4,7,2',4'-pentahydroxyflavone in in vitro and in vivo models |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/62558/ http://eprints.usm.my/62558/1/TEW%20WAN%20YIN%20-%20TESIS%20cut.pdf |