Diffusion tensor imaging and fibre tractography of leukoaraiosis
Diffusion tensor imaging (DTI) is an important technique in magnetic resonance imaging (MRI) which is utilized in brain imaging . DTI detects and measures mobility of water molecules in biological cells. It also provides scalar indices which is mean diffusivity (MD) and fractional anisotropy (FA)...
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| Format: | Monograph |
| Language: | English |
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Universiti Sains Malaysia
2016
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| Online Access: | http://eprints.usm.my/62553/ http://eprints.usm.my/62553/1/FATIN%20AYUNI%20BINTI%20HANAPI%20-%20e.pdf |
| _version_ | 1848885019783725056 |
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| author | Hanapi, Fatin Ayuni |
| author_facet | Hanapi, Fatin Ayuni |
| author_sort | Hanapi, Fatin Ayuni |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Diffusion tensor imaging (DTI) is an important technique in magnetic resonance
imaging (MRI) which is utilized in brain imaging . DTI detects and measures mobility
of water molecules in biological cells. It also provides scalar indices which is mean
diffusivity (MD) and fractional anisotropy (FA). Futhermore, the neuron fibre bundles
can be visualized by using special technique in DTI, namely fibre tractography.
Leukoaraiosis is a type of abnormal appearance in the white area of human brain and
this region appears hyperintense on T2- weighted and fluid attenuation inversion
recovery (FLAIR) magnetic resonance (MR) images. It is commonly found in normal
elderly which is related to ischemic stroke and cerebrovascular disease. The objective of
this study is to reconstruct the DTI parametric maps and fibre tractography and measure
the DTI values and number of fibres in corpus callosum(CC) and corticospinal
tract(CST). It is also to compare the FA and MD values obtained between right and left
of CST. The subject had leukoaraiosis at right side frontal white matter region and data
analysis was acquired by using commercial software, NordicICE Version 2.3.13. MD.
FA, and colour coded FA maps and fibre tractography were constructed. Region of
interest were located at corpus callosum and at right and left side of corticospinal tract.
For CST no differences was found for MD and FA values at both sides. Fibre
tractography showed right CST have 17.4% lesser number of fibers compared to left
CST. Whereas, for corpus callosum the MD value is 96.52 ± 30.34 and FA is 0.56 ±
0.19 with 11451 number of fibres. In conclusion, DTI parametric maps and fibre
tractography has been reconstructed, DTI values and number of fibres in CC and CST
also can be measured. The comparison of DTI values between right and left side of CST
was successfully obtained. |
| first_indexed | 2025-11-15T19:15:57Z |
| format | Monograph |
| id | usm-62553 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T19:15:57Z |
| publishDate | 2016 |
| publisher | Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-625532025-06-30T08:34:47Z http://eprints.usm.my/62553/ Diffusion tensor imaging and fibre tractography of leukoaraiosis Hanapi, Fatin Ayuni R Medicine (General) RC71-78.7 Examination. Diagnosis Including raiography Diffusion tensor imaging (DTI) is an important technique in magnetic resonance imaging (MRI) which is utilized in brain imaging . DTI detects and measures mobility of water molecules in biological cells. It also provides scalar indices which is mean diffusivity (MD) and fractional anisotropy (FA). Futhermore, the neuron fibre bundles can be visualized by using special technique in DTI, namely fibre tractography. Leukoaraiosis is a type of abnormal appearance in the white area of human brain and this region appears hyperintense on T2- weighted and fluid attenuation inversion recovery (FLAIR) magnetic resonance (MR) images. It is commonly found in normal elderly which is related to ischemic stroke and cerebrovascular disease. The objective of this study is to reconstruct the DTI parametric maps and fibre tractography and measure the DTI values and number of fibres in corpus callosum(CC) and corticospinal tract(CST). It is also to compare the FA and MD values obtained between right and left of CST. The subject had leukoaraiosis at right side frontal white matter region and data analysis was acquired by using commercial software, NordicICE Version 2.3.13. MD. FA, and colour coded FA maps and fibre tractography were constructed. Region of interest were located at corpus callosum and at right and left side of corticospinal tract. For CST no differences was found for MD and FA values at both sides. Fibre tractography showed right CST have 17.4% lesser number of fibers compared to left CST. Whereas, for corpus callosum the MD value is 96.52 ± 30.34 and FA is 0.56 ± 0.19 with 11451 number of fibres. In conclusion, DTI parametric maps and fibre tractography has been reconstructed, DTI values and number of fibres in CC and CST also can be measured. The comparison of DTI values between right and left side of CST was successfully obtained. Universiti Sains Malaysia 2016 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/62553/1/FATIN%20AYUNI%20BINTI%20HANAPI%20-%20e.pdf Hanapi, Fatin Ayuni (2016) Diffusion tensor imaging and fibre tractography of leukoaraiosis. Project Report. Universiti Sains Malaysia. (Submitted) |
| spellingShingle | R Medicine (General) RC71-78.7 Examination. Diagnosis Including raiography Hanapi, Fatin Ayuni Diffusion tensor imaging and fibre tractography of leukoaraiosis |
| title | Diffusion tensor imaging
and fibre tractography of leukoaraiosis |
| title_full | Diffusion tensor imaging
and fibre tractography of leukoaraiosis |
| title_fullStr | Diffusion tensor imaging
and fibre tractography of leukoaraiosis |
| title_full_unstemmed | Diffusion tensor imaging
and fibre tractography of leukoaraiosis |
| title_short | Diffusion tensor imaging
and fibre tractography of leukoaraiosis |
| title_sort | diffusion tensor imaging
and fibre tractography of leukoaraiosis |
| topic | R Medicine (General) RC71-78.7 Examination. Diagnosis Including raiography |
| url | http://eprints.usm.my/62553/ http://eprints.usm.my/62553/1/FATIN%20AYUNI%20BINTI%20HANAPI%20-%20e.pdf |