Synthesis And Molecular Docking Studies Of New Phenylisoxazole Quinoxaline-2-Amine Hybrids As Potential Α Amylase And Α-Glucosidase Inhibitors

QR Code

Synthesis And Molecular Docking Studies Of New Phenylisoxazole Quinoxaline-2-Amine Hybrids As Potential Α Amylase And Α-Glucosidase Inhibitors

New phenylisoxazole quinoxaline-2-amine hybrids 55a-i were successfully synthesised with percentage yield ranging from 53% to 85%. These compounds were purified and characterised by 1D- and 2D- NMR (1H, 13C, HSQC, HMBC and COSY), FTIR, and HRMS analyses. Then, the hybrids underwent in vitro α-amylas...

Full description

Bibliographic Details
Main Author:	Radzuan, Siti Nurshahira Mohd
Format:	Thesis
Language:	English
Published:	2024
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/62299/ http://eprints.usm.my/62299/1/24%20Pages%20from%20SITI%20NURSHAHIRA%20BINTI%20MOHD%20RADZUAN.pdf

Similar Items

Potential inhibitors of α-glucosidase and α-amylase enzymes from local fruit waste by solid state fermentation
by: Ahmad Barkat, Anumsima, et al.
Published: (2016)

Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors
by: Roney, Miah, et al.
Published: (2024)

Potential inhibitors of α-glucosidase and α-amylase enzymes from locally available fruit wastes by solid state fermentation
by: Ahmad Barkat, Anumsima, et al.
Published: (2019)

Molecular insight and mode of inhibition of α ‐Glucosidase and α ‐Amylase by Pahangensin A from Alpinia pahangensis Ridl.
by: Loo, Kong Yong, et al.
Published: (2019)

Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study
by: Noor Barak, Almandil, et al.
Published: (2019)

Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study
by: Almandil, Noor Barak, et al.
Published: (2019)

Evaluating the Effect of Combined Plant Extracts on α-amylase and α-glucosidase Inhibition Activity as Antidiabetic Agents
by: Munem, Osama A., et al.
Published: (2020)

Metabolomics combined with chemometric analysis to identify α-glucosidase inhibitors in Phaleria macrocarpa fruit extracts and its molecular docking simulation
by: Easmin, Sabina, et al.
Published: (2024)

Synthesis of diarylpentadienones and pyrazoline derivatives as potential α-glucosidase inhibitor and their antioxidant activities
by: Adam, Faruk Auwal, et al.
Published: (2023)

Synthesis, Characterisation And Molecular Docking Of Quinoxaline-isoxazole Hybrids As Potential Anti-hyperglycemic Agent
by: Phongphane, Lacksany
Published: (2024)

α-glucosidase inhibitors isolated from Mimosa pudica L.
by: Tasnuva, S. T., et al.
Published: (2017)

Characterization of α-glucosidase inhibitors from clinacanthus nutans lindau Llaves by gas chromatography-mass spectrometry-based metabolomics and molecular docking simulation
by: Murugesu, Suganya, et al.
Published: (2018)

α-Glucosidase inhibitors: consistency of: in silico docking data with in vitro inhibitory data and inhibitory effect prediction of quercetin derivatives
by: Zhu, Jianzhong, et al.
Published: (2019)

Stereospecific α-glucosidase inhibition, kinetics, and molecular docking studies on isolated diastereomeric alkaloids from Uncaria longiflora
by: Nurul Aina Suzlin, Sulaiman, et al.
Published: (2025)

Phenolic profiling and evaluation of in vitro antioxidant, α-glucosidase and α-amylase inhibitory activities of Lepisanthes fruticosa (Roxb) Leenh fruit extracts
by: Hasan Salahuddin, Mirfat Ahmad, et al.
Published: (2020)

Synthesis of cinnamamide derivatives and their α-glucosidase inhibitory activities
by: Teni Ernawati,, et al.
Published: (2020)

In vitro α-amylase and α-glucosidase inhibitory activities of selected Malaysian plants and in vivo antidiabetic properties of enema glauca / Mohamad Jemain Mohamad Ridhwan
by: Mohamad Ridhwan, Mohamad Jemain
Published: (2011)

Potent α-glucosidase and α-amylase inhibitory activities of standardized 50% ethanolic extracts and sinensetin from Orthosiphon stamineus Benth as anti-diabetic mechanism
by: Mohamed, Elsnoussi Ali Hussin, et al.
Published: (2012)

Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking
by: Murugesu, Suganya, et al.
Published: (2019)

Formulation of Momordica charantia fruit and Syzygium polyanthum leaf extracts based on in vitro antioxidant and inhibitory activity of α-amylase and α-glucosidase / Muhammad Jihad Sandikapura
by: Muhammad Jihad, Sandikapura
Published: (2018)

Screening Of Α-Glucosidase Inhibitors From Black Soybean Extract And Study On Their Inhibitory Mechanisms
by: Zheng, Yu
Published: (2024)

Cloning and Expression of a Thermostable-α Glucosidase
by: A. Mohamed, Rauda
Published: (2010)

Molecular Cloning and Expression of a Thermostable Α-Amylase from Geobacillus Sp.
by: Kassaye, Elias Kebede
Published: (2009)

α-Glucosidase and α-amylase Inhibitory Constituents of Tinospora crispa: Isolation and Chemical Profile Confirmation by Ultra-high Performance Liquid Chromatography-quadrupole Time-of-flight/mass spectrometry
by: Hazrulrizawati, Hamid, et al.
Published: (2015)

Native to designed: microbial α-amylases for industrial applications
by: Oslan, Siti Nurbaya, et al.
Published: (2021)

Investigation of α‐glucosidase inhibitory metabolites from Tetracera scandens leaves by GC–MS metabolite profiling and docking studies
by: Ahmed, Nokhala, et al.
Published: (2020)

Investigation of α-glucosidase inhibitory metabolites from Tetracera scandens leaves by GC–MS metabolite profiling and docking studies
by: Nokhala, Ahmed, et al.
Published: (2020)

α-Glucosidase inhibitory activity of selected Malaysian plants
by: Mohd Bukhari, Dzatil Awanis, et al.
Published: (2017)

In silico study of mangostin compounds and its derivatives as inhibitors of α-glucosidase enzymes for anti-diabetic studies
by: Maulana, Ahmad Fariz, et al.
Published: (2022)

Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis
by: Maryam Aisyah, Abdullah, et al.
Published: (2020)

Synthesis, Cytotoxicity Study, And Molecular Docking Of New Imidazole-Based Chalcone And Pyrazoline Hybrids
by: Bakar, Bazri Izwan
Published: (2023)

Identification of α-glucosidase inhibitorsfrom Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking
by: Murugesu, Suganya, et al.
Published: (2019)

Flavour-saliva interactions: implications of submaxillary mucin and α-amylase
by: Dinu, Vlad
Published: (2020)

Effect of tea polyphenols on α-amylase activity in starch hydrolysis
by: Nurul Nadiah Ismail,, et al.
Published: (2018)

Fluctuation of salivary α-amylase affected by the time change of injection
by: Mohd, Yusri, et al.
Published: (2012)

Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin
by: Nazikussabah, Zaharudin, et al.
Published: (2019)

Calcium-induced stabilization of α-amylase against guanidine hydrochloride denaturation
by: Tan, Cheau Yuaan, et al.
Published: (2010)

Binding mode analyses and pharmacophore model development for stilbene derivatives as a novel and competitive class of α-glucosidase inhibitors
by: Lee, Y., et al.
Published: (2014)

Identification of α-glucosidase inhibitory compounds from Curcuma mangga fractions
by: Awin, Tahani M., et al.
Published: (2020)

Production of α-amylase by immobilized bacillus subtilis in polymeric polyHIPE matrix
by: Jimat, Dzun Noraini, et al.
Published: (2013)