Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia
Background: Evolving targeted therapy on Janus Associated Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signalling pathway especially pertaining to STAT-3 protein in non-Hodgkin lymphoma (NHL), provide new treatment strategies. STAT-3 protein also related to prognostication of N...
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| Format: | Thesis |
| Language: | English |
| Published: |
2023
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| Online Access: | http://eprints.usm.my/62252/ http://eprints.usm.my/62252/1/Izyan%20Rifhana%20Muhamad-E.pdf |
| _version_ | 1848884931103555584 |
|---|---|
| author | Muhamad, Izyan Rifhana |
| author_facet | Muhamad, Izyan Rifhana |
| author_sort | Muhamad, Izyan Rifhana |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Background: Evolving targeted therapy on Janus Associated Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signalling pathway especially pertaining to STAT-3 protein in non-Hodgkin lymphoma (NHL), provide new treatment strategies. STAT-3 protein also related to prognostication of NHL. Hence, we aimed to evaluate the expression of STAT-3 protein in NHL cases, diagnosed in Hospital Universiti Sains Malaysia.
Methods: A retrospective cross sectional study using formalin fixed paraffin embedded tissue blocks of 95 NHL cases were obtained. STAT-3 immunostaining was performed and evaluated. The association between clinicopathological characteristics and STAT-3 protein expression was analysed using the Pearson chi-square and Fisher’s exact test. A p-value of < 0.05 is considered statistically significant.
Results: Majority of the cases (78.9 %) have positive STAT-3 protein expression. 64.2 % were among aggressive B cell NHL whilst 20 % of them are Diffuse Large B Cell Lymphoma, non-germinal centre B subtype (DLBCL-NGCB). There is significant association between STAT-3 protein expression with DLBCL subtypes (p = 0.046).
Conclusion: STAT-3 protein was significantly associated with DLBCL, one of the aggressive B cell lymphoma subtypes. It could be one of the possible markers to prognosis in NHL. However, a more extensive study with a combination of JAK protein needs to be done in the future to elucidate the mechanism of the JAK-STAT pathway in NHL and its associated role. |
| first_indexed | 2025-11-15T19:14:32Z |
| format | Thesis |
| id | usm-62252 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T19:14:32Z |
| publishDate | 2023 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-622522025-05-25T03:21:20Z http://eprints.usm.my/62252/ Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia Muhamad, Izyan Rifhana R Medicine RA440-440.87 Study and teaching. Research Background: Evolving targeted therapy on Janus Associated Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signalling pathway especially pertaining to STAT-3 protein in non-Hodgkin lymphoma (NHL), provide new treatment strategies. STAT-3 protein also related to prognostication of NHL. Hence, we aimed to evaluate the expression of STAT-3 protein in NHL cases, diagnosed in Hospital Universiti Sains Malaysia. Methods: A retrospective cross sectional study using formalin fixed paraffin embedded tissue blocks of 95 NHL cases were obtained. STAT-3 immunostaining was performed and evaluated. The association between clinicopathological characteristics and STAT-3 protein expression was analysed using the Pearson chi-square and Fisher’s exact test. A p-value of < 0.05 is considered statistically significant. Results: Majority of the cases (78.9 %) have positive STAT-3 protein expression. 64.2 % were among aggressive B cell NHL whilst 20 % of them are Diffuse Large B Cell Lymphoma, non-germinal centre B subtype (DLBCL-NGCB). There is significant association between STAT-3 protein expression with DLBCL subtypes (p = 0.046). Conclusion: STAT-3 protein was significantly associated with DLBCL, one of the aggressive B cell lymphoma subtypes. It could be one of the possible markers to prognosis in NHL. However, a more extensive study with a combination of JAK protein needs to be done in the future to elucidate the mechanism of the JAK-STAT pathway in NHL and its associated role. 2023 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/62252/1/Izyan%20Rifhana%20Muhamad-E.pdf Muhamad, Izyan Rifhana (2023) Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R Medicine RA440-440.87 Study and teaching. Research Muhamad, Izyan Rifhana Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia |
| title | Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia |
| title_full | Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia |
| title_fullStr | Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia |
| title_full_unstemmed | Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia |
| title_short | Evaluation of signal transducer and activator of transcription 3 (STAT-3) protein expression in non-hodgkin lymphoma cases in Hospital Universiti Sains Malaysia |
| title_sort | evaluation of signal transducer and activator of transcription 3 (stat-3) protein expression in non-hodgkin lymphoma cases in hospital universiti sains malaysia |
| topic | R Medicine RA440-440.87 Study and teaching. Research |
| url | http://eprints.usm.my/62252/ http://eprints.usm.my/62252/1/Izyan%20Rifhana%20Muhamad-E.pdf |