Investigation of antimalarial activity of crude Malaysian stingless bee propolis
Malaria is a mosquito-bome disease that is caused by plasmodium species and killed nearly 429, 000 people in 2015. With the emergence of plasmodium drug-resistance, many studies are conducted to find a new drug to treat malaria. Furthermore, with the resurgence of traditional medicine that is use...
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| Format: | Monograph |
| Language: | English |
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Universiti Sains Malaysia
2017
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| Online Access: | http://eprints.usm.my/62141/ http://eprints.usm.my/62141/2/NUR%20FATIN%20AYUNNI%20BINTI%20YUSOFF%20-%20e.pdf |
| Summary: | Malaria is a mosquito-bome disease that is caused by plasmodium species and killed
nearly 429, 000 people in 2015. With the emergence of plasmodium drug-resistance, many
studies are conducted to find a new drug to treat malaria. Furthermore, with the resurgence
of traditional medicine that is used to treat various disease nowadays, propolis as one of
the traditional medicine recorded to possess many medicinal values including antimalarial
property. Propolis is the resinous mixture produced by bees from the resin that collected
from the surrounding plants. Bees use propolis to protect its hives from an external
intruder by patching the propolis on the crack or the opening of the hive. However, there
is a very limited study on the Malaysian stingless bee propolis (Trigona itama) on its
antimalarial property. Therefore, this study was aimed to investigate the antimalarial
activity of Malaysian stingless bee propolis. The results of in vitro SYBR Green I-based
fluorescence assay against Chloroquine-sensitive Plasmodium falciparum (3D7) showed
both water extract (WEP) and ethanol extract (EEP) do not possess antimalarial activity.
The result is concordance with the very low level of total phenolic content (WEP; 16.4 ±
0.001 mg GAE/g and EEP; 31.3 ± 0.004 mg GAE/g) and total flavonoid content (WEP;
30 mg QE/g and EEP, n,d) isolated from the extracts. As this is a preliminary study on
looking antimalarial property of Malaysian propolis, therefore there is a need to do another
study to confirm the result. |
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