Evaluation of serai kayu (Sygyzium polyanthum) leaves extract as blood pressure lowering agent in hypertensive rat’s model
Syzygiumpolyanthum or “serai kayu” is popular among Kelantanese as traditional antihypertensive medicine. This study aimed to evaluate the effects of oral crude aqueous and methanol extracts of S.polyanthum (AESP and MESP, respectively) on blood pressure of spontaneous hypertensive rat (SHR) and...
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| Format: | Monograph |
| Language: | English |
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Universiti Sains Malaysia
2017
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| Online Access: | http://eprints.usm.my/62140/ http://eprints.usm.my/62140/1/NORFAZIRAH%20BINTI%20JAMAL%20-%20e.pdf |
| _version_ | 1848884900890935296 |
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| author | Jamal, Norfazirah |
| author_facet | Jamal, Norfazirah |
| author_sort | Jamal, Norfazirah |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Syzygiumpolyanthum or “serai kayu” is popular among Kelantanese as traditional
antihypertensive medicine. This study aimed to evaluate the effects of oral crude aqueous
and methanol extracts of S.polyanthum (AESP and MESP, respectively) on blood
pressure of spontaneous hypertensive rat (SHR) and the histopathology improvements on
the kidney of treated-SHR. AESP and MESP were prepared using ultrasound-assisted
(sonication) extraction technique. The changes of systolic blood pressure (SBP) were
recorded using non-invasive technique (tailed cuff method) over period of 24 h (acute
study) and 6 week (subacute study) of daily gavage. The kidney histopathology was
evaluated at the end of subacute study using hematoxylin and eosin (H&E) stain. AESP
at 1750 mg/kg significantly reduced SBP in the acute study (p<0.001). Similarly, MESP
at 2000 mg/kg significantly reduced SBP (p<0.001). For subacute study, both AESP and
MESP (at 1750 mg/kg and 2000 mg/kg, respectively) significantly reduced SBP started
at week 2 (p<0.001) and continue up until week 6 of intervention (p<0.00l). In
histopathology assessment, the kidney of MESP-treated SHR showed a well-preserved
glomerulus and well capsulated Bowman’s capsule. In contrast, AESP did not showed
the similar improvements. These results showed that despite both extracts had similar
profile on blood pressure reduction, only MESP improved the histopathology of the
kidney and to be potential antihypertensive agents. |
| first_indexed | 2025-11-15T19:14:03Z |
| format | Monograph |
| id | usm-62140 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T19:14:03Z |
| publishDate | 2017 |
| publisher | Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-621402025-07-21T03:28:18Z http://eprints.usm.my/62140/ Evaluation of serai kayu (Sygyzium polyanthum) leaves extract as blood pressure lowering agent in hypertensive rat’s model Jamal, Norfazirah R Medicine (General) R735-854 Medical education. Medical schools. Research Syzygiumpolyanthum or “serai kayu” is popular among Kelantanese as traditional antihypertensive medicine. This study aimed to evaluate the effects of oral crude aqueous and methanol extracts of S.polyanthum (AESP and MESP, respectively) on blood pressure of spontaneous hypertensive rat (SHR) and the histopathology improvements on the kidney of treated-SHR. AESP and MESP were prepared using ultrasound-assisted (sonication) extraction technique. The changes of systolic blood pressure (SBP) were recorded using non-invasive technique (tailed cuff method) over period of 24 h (acute study) and 6 week (subacute study) of daily gavage. The kidney histopathology was evaluated at the end of subacute study using hematoxylin and eosin (H&E) stain. AESP at 1750 mg/kg significantly reduced SBP in the acute study (p<0.001). Similarly, MESP at 2000 mg/kg significantly reduced SBP (p<0.001). For subacute study, both AESP and MESP (at 1750 mg/kg and 2000 mg/kg, respectively) significantly reduced SBP started at week 2 (p<0.001) and continue up until week 6 of intervention (p<0.00l). In histopathology assessment, the kidney of MESP-treated SHR showed a well-preserved glomerulus and well capsulated Bowman’s capsule. In contrast, AESP did not showed the similar improvements. These results showed that despite both extracts had similar profile on blood pressure reduction, only MESP improved the histopathology of the kidney and to be potential antihypertensive agents. Universiti Sains Malaysia 2017 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/62140/1/NORFAZIRAH%20BINTI%20JAMAL%20-%20e.pdf Jamal, Norfazirah (2017) Evaluation of serai kayu (Sygyzium polyanthum) leaves extract as blood pressure lowering agent in hypertensive rat’s model. Project Report. Universiti Sains Malaysia. (Submitted) |
| spellingShingle | R Medicine (General) R735-854 Medical education. Medical schools. Research Jamal, Norfazirah Evaluation of serai kayu (Sygyzium polyanthum) leaves extract as blood pressure lowering agent in hypertensive rat’s model |
| title | Evaluation of serai kayu (Sygyzium
polyanthum) leaves extract as blood
pressure lowering agent in
hypertensive rat’s model |
| title_full | Evaluation of serai kayu (Sygyzium
polyanthum) leaves extract as blood
pressure lowering agent in
hypertensive rat’s model |
| title_fullStr | Evaluation of serai kayu (Sygyzium
polyanthum) leaves extract as blood
pressure lowering agent in
hypertensive rat’s model |
| title_full_unstemmed | Evaluation of serai kayu (Sygyzium
polyanthum) leaves extract as blood
pressure lowering agent in
hypertensive rat’s model |
| title_short | Evaluation of serai kayu (Sygyzium
polyanthum) leaves extract as blood
pressure lowering agent in
hypertensive rat’s model |
| title_sort | evaluation of serai kayu (sygyzium
polyanthum) leaves extract as blood
pressure lowering agent in
hypertensive rat’s model |
| topic | R Medicine (General) R735-854 Medical education. Medical schools. Research |
| url | http://eprints.usm.my/62140/ http://eprints.usm.my/62140/1/NORFAZIRAH%20BINTI%20JAMAL%20-%20e.pdf |