Evaluation of serai kayu (Sygyzium polyanthum) leaves extract as blood pressure lowering agent in hypertensive rat’s model
Syzygiumpolyanthum or “serai kayu” is popular among Kelantanese as traditional antihypertensive medicine. This study aimed to evaluate the effects of oral crude aqueous and methanol extracts of S.polyanthum (AESP and MESP, respectively) on blood pressure of spontaneous hypertensive rat (SHR) and...
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| Format: | Monograph |
| Language: | English |
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Universiti Sains Malaysia
2017
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| Online Access: | http://eprints.usm.my/62140/ http://eprints.usm.my/62140/1/NORFAZIRAH%20BINTI%20JAMAL%20-%20e.pdf |
| Summary: | Syzygiumpolyanthum or “serai kayu” is popular among Kelantanese as traditional
antihypertensive medicine. This study aimed to evaluate the effects of oral crude aqueous
and methanol extracts of S.polyanthum (AESP and MESP, respectively) on blood
pressure of spontaneous hypertensive rat (SHR) and the histopathology improvements on
the kidney of treated-SHR. AESP and MESP were prepared using ultrasound-assisted
(sonication) extraction technique. The changes of systolic blood pressure (SBP) were
recorded using non-invasive technique (tailed cuff method) over period of 24 h (acute
study) and 6 week (subacute study) of daily gavage. The kidney histopathology was
evaluated at the end of subacute study using hematoxylin and eosin (H&E) stain. AESP
at 1750 mg/kg significantly reduced SBP in the acute study (p<0.001). Similarly, MESP
at 2000 mg/kg significantly reduced SBP (p<0.001). For subacute study, both AESP and
MESP (at 1750 mg/kg and 2000 mg/kg, respectively) significantly reduced SBP started
at week 2 (p<0.001) and continue up until week 6 of intervention (p<0.00l). In
histopathology assessment, the kidney of MESP-treated SHR showed a well-preserved
glomerulus and well capsulated Bowman’s capsule. In contrast, AESP did not showed
the similar improvements. These results showed that despite both extracts had similar
profile on blood pressure reduction, only MESP improved the histopathology of the
kidney and to be potential antihypertensive agents. |
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