Effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital Universiti Sains Malaysia
Introduction The objectives of this study are to compare thyroid hormone levels in term asphyxiated newborns versus healthy controls and to determine potential correlations between the severity of birth asphyxia and the thyroid hormone levels. Methods A prospective case-control study was perf...
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| Format: | Thesis |
| Language: | English |
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2023
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| Online Access: | http://eprints.usm.my/62052/ http://eprints.usm.my/62052/1/Ahmad%20Zafrullah%20Afham%20Ahmad%20Fikri-E.pdf |
| _version_ | 1848884876602769408 |
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| author | Fikri, Ahmad Zafrullah Afham Ahmad |
| author_facet | Fikri, Ahmad Zafrullah Afham Ahmad |
| author_sort | Fikri, Ahmad Zafrullah Afham Ahmad |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Introduction
The objectives of this study are to compare thyroid hormone levels in term asphyxiated newborns versus healthy controls and to determine potential correlations between the severity of birth asphyxia and the thyroid hormone levels.
Methods
A prospective case-control study was performed by comparing cases of birth asphyxia with the healthy controls. The primary outcomes included cord blood Thyroid Stimulating Hormone (TSH), and TSH and Free Thyroxine 4 (FT4) levels at 24-36 hours after birth. Correlations were sought between the severity of birth asphyxia with the thyroid hormone levels for the cases.
Results
The study included 20 cases and 21 controls. Demographic data were similar for the two groups except for a significantly higher Caesarean section rate in the control group. There were no significant differences between the groups in the cord TSH and the 24-36 hours FT4 levels, but the median (IQR) TSH level at 24 to 36 hours was significantly lower in the case group than in the control group, (8.3 mIU/L(4.5-13.7) versus 14.1 mIU/L(9.4-17.0); p<0.05). The highest Thompson scores within the first six hours after birth was significantly correlated with lower TSH levels (r of -0.468; p<0.05). There was also a significant correlation between the Apgar score at 10 minutes and the level of FT4 at 24-36 hours after birth (r of 0.501; p<0.05).
Conclusion
This study showed that TSH at 24-36 hours after birth was significantly lower in asphyxiated newborns. Selected parameters of the severity of birth asphyxia correlated with thyroid hormone levels at 24-36 hours. |
| first_indexed | 2025-11-15T19:13:40Z |
| format | Thesis |
| id | usm-62052 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T19:13:40Z |
| publishDate | 2023 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-620522025-05-25T00:53:19Z http://eprints.usm.my/62052/ Effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital Universiti Sains Malaysia Fikri, Ahmad Zafrullah Afham Ahmad R Medicine Introduction The objectives of this study are to compare thyroid hormone levels in term asphyxiated newborns versus healthy controls and to determine potential correlations between the severity of birth asphyxia and the thyroid hormone levels. Methods A prospective case-control study was performed by comparing cases of birth asphyxia with the healthy controls. The primary outcomes included cord blood Thyroid Stimulating Hormone (TSH), and TSH and Free Thyroxine 4 (FT4) levels at 24-36 hours after birth. Correlations were sought between the severity of birth asphyxia with the thyroid hormone levels for the cases. Results The study included 20 cases and 21 controls. Demographic data were similar for the two groups except for a significantly higher Caesarean section rate in the control group. There were no significant differences between the groups in the cord TSH and the 24-36 hours FT4 levels, but the median (IQR) TSH level at 24 to 36 hours was significantly lower in the case group than in the control group, (8.3 mIU/L(4.5-13.7) versus 14.1 mIU/L(9.4-17.0); p<0.05). The highest Thompson scores within the first six hours after birth was significantly correlated with lower TSH levels (r of -0.468; p<0.05). There was also a significant correlation between the Apgar score at 10 minutes and the level of FT4 at 24-36 hours after birth (r of 0.501; p<0.05). Conclusion This study showed that TSH at 24-36 hours after birth was significantly lower in asphyxiated newborns. Selected parameters of the severity of birth asphyxia correlated with thyroid hormone levels at 24-36 hours. 2023 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/62052/1/Ahmad%20Zafrullah%20Afham%20Ahmad%20Fikri-E.pdf Fikri, Ahmad Zafrullah Afham Ahmad (2023) Effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital Universiti Sains Malaysia. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R Medicine Fikri, Ahmad Zafrullah Afham Ahmad Effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital Universiti Sains Malaysia |
| title | Effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital Universiti Sains Malaysia |
| title_full | Effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital Universiti Sains Malaysia |
| title_fullStr | Effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital Universiti Sains Malaysia |
| title_full_unstemmed | Effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital Universiti Sains Malaysia |
| title_short | Effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital Universiti Sains Malaysia |
| title_sort | effect of birth asphyxia on the thyroid hormone in term newborn delivered in hospital universiti sains malaysia |
| topic | R Medicine |
| url | http://eprints.usm.my/62052/ http://eprints.usm.my/62052/1/Ahmad%20Zafrullah%20Afham%20Ahmad%20Fikri-E.pdf |