Anti-candida activity of methanolic oroxylum indicum leaves extract against candida species
Oroxylum indicum has been used traditionally to treat common ailments and its leave extract has been reported to possess antimicrobial properties. The aim of this study was to evaluate the in-vitro anti-Candida activity of Oroxylum indicum leaves extract against selected Candida species. Methanol...
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| Format: | Monograph |
| Language: | English |
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Universiti Sains Malaysia
2024
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| Online Access: | http://eprints.usm.my/61997/ http://eprints.usm.my/61997/1/AMALINA%20BINTI%20AB%20RAHMAN%20-%20e.pdf |
| _version_ | 1848884862061117440 |
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| author | Rahman, Amalina Ab |
| author_facet | Rahman, Amalina Ab |
| author_sort | Rahman, Amalina Ab |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Oroxylum indicum has been used traditionally to treat common ailments and its leave
extract has been reported to possess antimicrobial properties. The aim of this study was
to evaluate the in-vitro anti-Candida activity of Oroxylum indicum leaves extract
against selected Candida species. Methanolic leaves extract of Oroxylum indicum was
tested for anti-Candida activity against C. albicans, C. tropicalis, C. parapsilopsis, C.
krusei, and C. glabrata. Anti-Candida activities were evaluated by well-diffusion
method and the minimum inhibitory concentrations (MIC) were determined using the
two-fold serial broth microdilution technique of concentration ranging from 500.0
mg/mL to 3.9 mg/mL. After 24 hours of incubation, the minimum fungicidal
concentration (MFC) was determined by sub-culturing the wells which showed no turbidity onto Sabouraud dextrose agar (SDA). The presence of potential phytochemicals group in the crude extract was screened by phytochemical qualitative
tests. The methanolic extract showed moderate (50% of inhibition zone) anti-Candida
activity against C. albicans and C. krusei. C. albicans was the most susceptible among
the tested Candida species and showed a low MIC value (78 mg/mL). The extract was
also fungicidal to C. albicans (MFC/MIC ratio of 4.0). Flavonoid, tannin, triterpenoid
and steroid were the major phytochemicals of the crude extract. This study suggested
that methanolic Oroxylum indicum leaves extract has weak anti-Candida activity. |
| first_indexed | 2025-11-15T19:13:26Z |
| format | Monograph |
| id | usm-61997 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T19:13:26Z |
| publishDate | 2024 |
| publisher | Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-619972025-03-24T06:36:51Z http://eprints.usm.my/61997/ Anti-candida activity of methanolic oroxylum indicum leaves extract against candida species Rahman, Amalina Ab R Medicine (General) RA440-440.87 Study and teaching. Research Oroxylum indicum has been used traditionally to treat common ailments and its leave extract has been reported to possess antimicrobial properties. The aim of this study was to evaluate the in-vitro anti-Candida activity of Oroxylum indicum leaves extract against selected Candida species. Methanolic leaves extract of Oroxylum indicum was tested for anti-Candida activity against C. albicans, C. tropicalis, C. parapsilopsis, C. krusei, and C. glabrata. Anti-Candida activities were evaluated by well-diffusion method and the minimum inhibitory concentrations (MIC) were determined using the two-fold serial broth microdilution technique of concentration ranging from 500.0 mg/mL to 3.9 mg/mL. After 24 hours of incubation, the minimum fungicidal concentration (MFC) was determined by sub-culturing the wells which showed no turbidity onto Sabouraud dextrose agar (SDA). The presence of potential phytochemicals group in the crude extract was screened by phytochemical qualitative tests. The methanolic extract showed moderate (50% of inhibition zone) anti-Candida activity against C. albicans and C. krusei. C. albicans was the most susceptible among the tested Candida species and showed a low MIC value (78 mg/mL). The extract was also fungicidal to C. albicans (MFC/MIC ratio of 4.0). Flavonoid, tannin, triterpenoid and steroid were the major phytochemicals of the crude extract. This study suggested that methanolic Oroxylum indicum leaves extract has weak anti-Candida activity. Universiti Sains Malaysia 2024-08 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/61997/1/AMALINA%20BINTI%20AB%20RAHMAN%20-%20e.pdf Rahman, Amalina Ab (2024) Anti-candida activity of methanolic oroxylum indicum leaves extract against candida species. Project Report. Universiti Sains Malaysia. (Submitted) |
| spellingShingle | R Medicine (General) RA440-440.87 Study and teaching. Research Rahman, Amalina Ab Anti-candida activity of methanolic oroxylum indicum leaves extract against candida species |
| title | Anti-candida activity of methanolic
oroxylum indicum leaves extract against candida species |
| title_full | Anti-candida activity of methanolic
oroxylum indicum leaves extract against candida species |
| title_fullStr | Anti-candida activity of methanolic
oroxylum indicum leaves extract against candida species |
| title_full_unstemmed | Anti-candida activity of methanolic
oroxylum indicum leaves extract against candida species |
| title_short | Anti-candida activity of methanolic
oroxylum indicum leaves extract against candida species |
| title_sort | anti-candida activity of methanolic
oroxylum indicum leaves extract against candida species |
| topic | R Medicine (General) RA440-440.87 Study and teaching. Research |
| url | http://eprints.usm.my/61997/ http://eprints.usm.my/61997/1/AMALINA%20BINTI%20AB%20RAHMAN%20-%20e.pdf |