Unveiling safety profile of Pereskia bleo leaf extract: A comprehensive study on female toxicity and teratogenicity in Sprague Dawley rats
Pereskia bleo (P. bleo), renowned for its traditional medicinal use in various countries, is valued for its therapeutic potential. While medicinal plants hold immense promise, concerns regarding potential adverse effects on normal cells and teratogenicity remain. This study evaluated the influence o...
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| Format: | Article |
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Journal of Chemical Health Risks
2024
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| Online Access: | http://eprints.usm.my/60833/ http://eprints.usm.my/60833/1/Published-Dr._Norzila_Ismail_student-Manuscript_30-05-2024%5B3%5D.pdf |
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| author | Khalaf, Taif Kareem Nazri, Nor Amalia Abdulrazak, Mohammed Hussain Bakar, Ainul Bahiyah Abu Ezumi, Mohd Fuad Wan Ismail, Norzila |
| author_facet | Khalaf, Taif Kareem Nazri, Nor Amalia Abdulrazak, Mohammed Hussain Bakar, Ainul Bahiyah Abu Ezumi, Mohd Fuad Wan Ismail, Norzila |
| author_sort | Khalaf, Taif Kareem |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Pereskia bleo (P. bleo), renowned for its traditional medicinal use in various countries, is valued for its therapeutic potential. While medicinal plants hold immense promise, concerns regarding potential adverse effects on normal cells and teratogenicity remain. This study evaluated the influence of methanol extract of Pereskia bleo (MEPB) leaves on female toxicity and teratogenicity in Sprague Dawley rats. Female rats (n=40) were divided into four groups receiving MEPB doses (0, 250, 500, and 1000 mg/kg/day) during pre-mating, mating, and gestation periods. Gas Chromatography-Mass Spectrometry (GC-MS) analysis exhibited that MEPB leaves contain phenolic compounds, terpenoids, phytosterols, and fatty acids. Remarkably, all the animals exhibited regular oestrous cycles, maintaining body weight, and showed no signs of toxicity or abnormal behavior. Visceral organ weights and histological analysis revealed no significant alterations, attesting to the extract's safety. Pregnancy outcomes, including corpora lutea, implantation sites, percentages of pre- and post- implantation death, gravid uterine weight, number of live and dead fetuses, fetal body weight, and fetal sex ratio, remained unaffected. Furthermore, meticulous fetal examinations confirmed that MEPB did not impact foetal parameters or induce deformities. Importantly, daily MEPB consumption (250-1000 mg/kg) from pre-pregnancy to pregnancy did not compromise maternal or fetal well-being. These results underscore the lack of embryotoxic or teratogenic effects of MEPB, highlighting its
potential for safe therapeutic applications. |
| first_indexed | 2025-11-15T19:08:29Z |
| format | Article |
| id | usm-60833 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T19:08:29Z |
| publishDate | 2024 |
| publisher | Journal of Chemical Health Risks |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-608332024-09-11T04:12:24Z http://eprints.usm.my/60833/ Unveiling safety profile of Pereskia bleo leaf extract: A comprehensive study on female toxicity and teratogenicity in Sprague Dawley rats Khalaf, Taif Kareem Nazri, Nor Amalia Abdulrazak, Mohammed Hussain Bakar, Ainul Bahiyah Abu Ezumi, Mohd Fuad Wan Ismail, Norzila RA Public aspects of medicine RA440-440.87 Study and teaching. Research Pereskia bleo (P. bleo), renowned for its traditional medicinal use in various countries, is valued for its therapeutic potential. While medicinal plants hold immense promise, concerns regarding potential adverse effects on normal cells and teratogenicity remain. This study evaluated the influence of methanol extract of Pereskia bleo (MEPB) leaves on female toxicity and teratogenicity in Sprague Dawley rats. Female rats (n=40) were divided into four groups receiving MEPB doses (0, 250, 500, and 1000 mg/kg/day) during pre-mating, mating, and gestation periods. Gas Chromatography-Mass Spectrometry (GC-MS) analysis exhibited that MEPB leaves contain phenolic compounds, terpenoids, phytosterols, and fatty acids. Remarkably, all the animals exhibited regular oestrous cycles, maintaining body weight, and showed no signs of toxicity or abnormal behavior. Visceral organ weights and histological analysis revealed no significant alterations, attesting to the extract's safety. Pregnancy outcomes, including corpora lutea, implantation sites, percentages of pre- and post- implantation death, gravid uterine weight, number of live and dead fetuses, fetal body weight, and fetal sex ratio, remained unaffected. Furthermore, meticulous fetal examinations confirmed that MEPB did not impact foetal parameters or induce deformities. Importantly, daily MEPB consumption (250-1000 mg/kg) from pre-pregnancy to pregnancy did not compromise maternal or fetal well-being. These results underscore the lack of embryotoxic or teratogenic effects of MEPB, highlighting its potential for safe therapeutic applications. Journal of Chemical Health Risks 2024-05-28 Article PeerReviewed application/pdf en http://eprints.usm.my/60833/1/Published-Dr._Norzila_Ismail_student-Manuscript_30-05-2024%5B3%5D.pdf Khalaf, Taif Kareem and Nazri, Nor Amalia and Abdulrazak, Mohammed Hussain and Bakar, Ainul Bahiyah Abu and Ezumi, Mohd Fuad Wan and Ismail, Norzila (2024) Unveiling safety profile of Pereskia bleo leaf extract: A comprehensive study on female toxicity and teratogenicity in Sprague Dawley rats. Journal of Chemical Health Risks, 14 (3). pp. 740-755. ISSN 2251-6727 |
| spellingShingle | RA Public aspects of medicine RA440-440.87 Study and teaching. Research Khalaf, Taif Kareem Nazri, Nor Amalia Abdulrazak, Mohammed Hussain Bakar, Ainul Bahiyah Abu Ezumi, Mohd Fuad Wan Ismail, Norzila Unveiling safety profile of Pereskia bleo leaf extract: A comprehensive study on female toxicity and teratogenicity in Sprague Dawley rats |
| title | Unveiling safety profile of Pereskia bleo leaf extract: A comprehensive study on female toxicity and teratogenicity in Sprague Dawley rats |
| title_full | Unveiling safety profile of Pereskia bleo leaf extract: A comprehensive study on female toxicity and teratogenicity in Sprague Dawley rats |
| title_fullStr | Unveiling safety profile of Pereskia bleo leaf extract: A comprehensive study on female toxicity and teratogenicity in Sprague Dawley rats |
| title_full_unstemmed | Unveiling safety profile of Pereskia bleo leaf extract: A comprehensive study on female toxicity and teratogenicity in Sprague Dawley rats |
| title_short | Unveiling safety profile of Pereskia bleo leaf extract: A comprehensive study on female toxicity and teratogenicity in Sprague Dawley rats |
| title_sort | unveiling safety profile of pereskia bleo leaf extract: a comprehensive study on female toxicity and teratogenicity in sprague dawley rats |
| topic | RA Public aspects of medicine RA440-440.87 Study and teaching. Research |
| url | http://eprints.usm.my/60833/ http://eprints.usm.my/60833/1/Published-Dr._Norzila_Ismail_student-Manuscript_30-05-2024%5B3%5D.pdf |