Lymphovascular invasion in breast carcinoma
Lymphovascular invasion comprising of blood vascular invasion and lymphatic vessel invasion has become one of the important existence in breast carcinoma. However, it is not clear which type of vascular invasion plays a major role in metastasis. The aims of this study were to investigate the role...
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| Format: | Monograph |
| Language: | English |
| Published: |
Universiti Sains Malaysia
2015
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| Online Access: | http://eprints.usm.my/60297/ http://eprints.usm.my/60297/1/NUR%20FATIHA%20BINTI%20NORHISHAM%20-%20e.pdf |
| Summary: | Lymphovascular invasion comprising of blood vascular invasion and lymphatic
vessel invasion has become one of the important existence in breast carcinoma. However, it is not clear which type of vascular invasion plays a major role in metastasis.
The aims of this study were to investigate the role of lymphatic and blood vessel
invasion, and lymphatic and microvessel density as prognostic biomarkers in 19 breast carcinoma patients. Immunohistochemical method was used where sections of breast carcinoma were stained with anti-D2-40 and anti-CD34 antibodies to evaluate lymphatic and blood vessel invasion respectively. Vascular invasion by
immunohistochemical method was compared with vascular invasion determined by
hematoxylin & eosin (H&E) staining. Vascular invasion was also assessed by
correlating with clinicopathological criteria. Vascular invasion was detected in 16
(84.2%) cases; 5/16 (31.3%) were lymphatic vessel invasion, 2/16 (72.5%) were blood
vessel invasion and 9/16 (56.3%) showed both lymphatic and blood vessel invasion.
Intratumoral lymphatic vessel invasion was significantly associated with tumor size
(p=0.029), while peritumoral lymphatic vessel invasion was associated with distant
metastasis (p-0.018) and blood vessel invasion (p=0.024). These results suggest that
vascular invasion in breast carcinoma predominantly occurs via lymphatic vessels and
the association of lymphatic invasion with distant metastasis provides evidence for their
biological importance in breast carcinoma. Hence, it is suggested that lymphatic
invasion be included in clinical practices as one of the potential prognostic biomarkers
of breast carcinoma. |
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