Evaluation Of Toxicity, Pharmacokinetic And Clastogenicity Profile Of Ethyl 2-[4[(Piperidin-1-yl) Phenyl]-1h-benzimidazole-5-carboxylate (Bzd9l1), Novel Sirtuin Inhibitor
The mammalian sirtuins (SIRTs) have been linked to various diseases including cancer, diabetes, neurodegenerative and cardiovascular diseases. Thus, SIRTs are attractive targets for the development of pharmaceuticals. The lack of potential SIRT inhibitors in cancer clinical trials highlights the nee...
| Main Author: | Lee, Yeuan Ting |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2022
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/59372/ http://eprints.usm.my/59372/1/LEE%20YEUAN%20TING%20-%20TESIS24.pdf |
Similar Items
Mechanism Of Action Of A Benzimidazole Sirtuin Inhibitor, Bzd9l1, In Colorectal Cancer
by: Tan, Yi Jer
Published: (2022)
by: Tan, Yi Jer
Published: (2022)
Ethyl 1-sec-butyl-2-phenyl-1H-benzimidazole-5-carboxylate
by: Arumugam, Natarajan, et al.
Published: (2010)
by: Arumugam, Natarajan, et al.
Published: (2010)
Ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzimidazole-5-carboxylate
by: Hamzah, Nurasyikin, et al.
Published: (2010)
by: Hamzah, Nurasyikin, et al.
Published: (2010)
Ethyl 1-(butan-2-yl)-2-(2-methoxyphenyl)-
1H-benzimidazole-5-carboxylate
by: Natarajan, Arumugam, et al.
Published: (2011)
by: Natarajan, Arumugam, et al.
Published: (2011)
Ethyl 1-(2-hydroxyethyl)-2-[2-(methylsulfanyl)ethyl]-1H-benzimidazole-5-carboxylate
by: Hamzah, Nurasyikin, et al.
Published: (2012)
by: Hamzah, Nurasyikin, et al.
Published: (2012)
Ethyl 1-(2-hydroxyethyl)-2-propyl-1H-benzimidazole-5-carboxylate
by: Hamzah, Nurasyikin, et al.
Published: (2011)
by: Hamzah, Nurasyikin, et al.
Published: (2011)
Ethyl 1-tert-butyl-2-(4-methoxyphenyl)-1H-benzimidazole-5-carboxylate
by: Arumugam, Natarajan, et al.
Published: (2010)
by: Arumugam, Natarajan, et al.
Published: (2010)
Ethyl 2-(4-bromophenyl)-1-sec-butyl-1H-benzimidazole-5-carboxylate
by: Arumugam, Natarajan, et al.
Published: (2011)
by: Arumugam, Natarajan, et al.
Published: (2011)
1-[4-(Prop-2-en-1-yloxy)benzyl]-2-[4-(prop-2-en-1-yloxy)phenyl]-1H benzimidazole
by: Hegde, Gurumurthy, et al.
Published: (2012)
by: Hegde, Gurumurthy, et al.
Published: (2012)
Ethyl 1-(2-hydroxyethyl)-2-(4-methoxyphenyl)-1H-benzimidazole-5-carboxylate monohydrate
by: Arumugam, Natarajan, et al.
Published: (2012)
by: Arumugam, Natarajan, et al.
Published: (2012)
Bzd9l1: Elucidation Of Its Anti-angiogenic Potential In In-vitro And In-vivo Colorectal Cancer Models
by: Subramaniam, Ayappa V.
Published: (2023)
by: Subramaniam, Ayappa V.
Published: (2023)
Synthesis And Biological Activity Of Benzimidazole Analogs As Sirtuin Enzyme Inhibitors
by: Yeong, Keng Yoon
Published: (2016)
by: Yeong, Keng Yoon
Published: (2016)
3-amino-5-(piperidin-1-yl)thiophene-2,4-dicarbonitrile
by: Al-Adiwish, Wedad M., et al.
Published: (2012)
by: Al-Adiwish, Wedad M., et al.
Published: (2012)
Ethyl 1-(2,4-dichlorobenzyl)-4-oxo-7-trifluoromethyl-1,4-dihydroquinoline-3-carboxylate
by: Hegde, Gurumurthy, et al.
Published: (2012)
by: Hegde, Gurumurthy, et al.
Published: (2012)
2-sec-Butyl-1-(2-hydroxyethyl)-1H-benzimidazole-5-carboxylic acid
by: Hamzah, Nurasyikin, et al.
Published: (2012)
by: Hamzah, Nurasyikin, et al.
Published: (2012)
3-Oxo-5-(piperidin-1-yl)-2,3-dihydro-1H-pyrazole-4-carbonitrile
by: Al-Adiwish, Wedad M., et al.
Published: (2011)
by: Al-Adiwish, Wedad M., et al.
Published: (2011)
ethyl 1-sec-butyl-2-(4-fluorophenyl)-1H-benzimidazole-5-carboylate
by: Arumugam, Natarajan, et al.
Published: (2011)
by: Arumugam, Natarajan, et al.
Published: (2011)
Fundamental studies on the mechanism of action of a novel sirtuin inhibitor (BZD9L 1) in colorectal cancer cells- towards the elucidation of a novel cancer therapeutic agent.
by: Oon , Chern Ein
Published: (2016)
by: Oon , Chern Ein
Published: (2016)
Crystal structure of 3-(5-amino-1H-1,2,4-triazol-3-yl)-1-(piperidin-1-yl)propan-1-one, C10H17N5O
by: Tan, Lin Yuing, et al.
Published: (2019)
by: Tan, Lin Yuing, et al.
Published: (2019)
2-[1-(2-hydroxy-3-methoxybenzyl)-1H-benzimidazol-2-yl]-6-methoxyphenol monohydrate
by: Al-Douh, Mohammed Hadi, et al.
Published: (2009)
by: Al-Douh, Mohammed Hadi, et al.
Published: (2009)
2-[1-(2-Hydroxy-3-methoxybenzyl)-1H-benzimidazol-2-yl]-6-methoxyphenol methanol 1.13-solvate
by: Al-Douh, Mohammed H., et al.
Published: (2009)
by: Al-Douh, Mohammed H., et al.
Published: (2009)
N-Carbethoxy-N'-(3-phenyl-1H-1,2,4-triazol-5-yl)thiourea
by: Dolzhenko, Anton, et al.
Published: (2010)
by: Dolzhenko, Anton, et al.
Published: (2010)
4-{(E)-2-[4-(But-3-en-1-yloxy)phenyl]diazen-1-yl}Benzoic Acid
by: Lutfor, M. R., et al.
Published: (2012)
by: Lutfor, M. R., et al.
Published: (2012)
Crystal structure of ethyl 4-{[5-(adamantan-1-yl)-2-sulfanylidene-2,3-dihydro-1,3,4-oxadiazol-3-yl]methyl}piperazine-1-carboxylate, C20H30N4O3S
by: Al-Sanea, Mohammad M., et al.
Published: (2023)
by: Al-Sanea, Mohammad M., et al.
Published: (2023)
3-(Adamantan-1-yl)-4-ethyl-1-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-1H-1,2,4-triazole-5(4H)-thione
by: El-Emam, Ali A., et al.
Published: (2014)
by: El-Emam, Ali A., et al.
Published: (2014)
N,N'-Bis(phenyl-carbamo-thio-yl)benzene-1,3-dicarboxamide
by: Zainab, Ngaini, et al.
Published: (2013)
by: Zainab, Ngaini, et al.
Published: (2013)
Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate
by: Schwehm, Carolin, et al.
Published: (2014)
by: Schwehm, Carolin, et al.
Published: (2014)
Novel diastereoisomers of C21H20O3 obtained from the cathodic reduction of methyl (2E)-3-[2-(2-{2-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)phenyl]prop-2-enoate
by: Curilazo, Ricardo, et al.
Published: (2017)
by: Curilazo, Ricardo, et al.
Published: (2017)
Ethyl 3,4-bis(acetyloxy)-2-(4-methoxyphenyl)pyrrolidine-1-carboxylate
by: Dallasta Pedroso, Sofia, et al.
Published: (2020)
by: Dallasta Pedroso, Sofia, et al.
Published: (2020)
Synthesis and in vitro antiproliferative activity of new 1-phenyl-3-(4-(pyridin-3-yl)phenyl)urea scaffold-based compounds
by: Al-Sanea, Mohammad M., et al.
Published: (2018)
by: Al-Sanea, Mohammad M., et al.
Published: (2018)
n-Butyldichlorido (2-{(1E)-1-[2-(pyridin-2-yl) hydrazin-1-ylidene] ethyl} phenolato) tin (IV)
by: Fasihuddin Badruddin, Ahmad, et al.
Published: (2010)
by: Fasihuddin Badruddin, Ahmad, et al.
Published: (2010)
Benzyl N-[1-(thiophen-2-yl)ethylidene)]-hydrazinecarbodithioate
by: Chan, Eddy Mun Hoe, et al.
Published: (2003)
by: Chan, Eddy Mun Hoe, et al.
Published: (2003)
4-(3,4-Dimethyl-5-phenyl-1,3-oxazolidin-2-yl)-2-methoxyphenol
by: Mohd Razip, Asaruddin, et al.
Published: (2010)
by: Mohd Razip, Asaruddin, et al.
Published: (2010)
A monoclinic polymorph of N-ethoxycarbonyl-N'-(3-phenyl-1H-1,2,4-triazol-5-yl)thiourea
by: Dolzhenko, Anton, et al.
Published: (2010)
by: Dolzhenko, Anton, et al.
Published: (2010)
Crystal structure of ethyl 4-methyl-2-oxo-5-phenyl-1,3,4-oxadiazinane-3-carboxylate, C13H16N2O4
by: Caracelli, Ignez, et al.
Published: (2020)
by: Caracelli, Ignez, et al.
Published: (2020)
3-Phenyl-1H-1,2,4-triazol-5-amine-5-phenyl-1H-1,2,4-triazol-3-amine (1/1).
by: Dolzhenko, Anton, et al.
Published: (2009)
by: Dolzhenko, Anton, et al.
Published: (2009)
2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium trichloroacetate: Crystal structure and Hirshfeld surface analysis
by: Wardell, James L., et al.
Published: (2018)
by: Wardell, James L., et al.
Published: (2018)
Pharmacokinetics And Metabolism Studies
Of Antifilarial Drugs
Derivatives Of Benzimidazole Carbamate
by: Ramanathan, Surash
Published: (1996)
by: Ramanathan, Surash
Published: (1996)
2-Bromo-4-(3,4-dimethyl-5-phenyl-1,3-oxazolidin-2-yl)-6-
methoxyphenol
by: Hariono, Maywan, et al.
Published: (2012)
by: Hariono, Maywan, et al.
Published: (2012)
Methyl 3-[(1-benzyl-4-phenyl-1H-1,2,3-triazol-5-yl)formamido]propanoate: crystal structure, Hirshfeld surface analysis and computational chemistry
by: Caracelli, Ignez, et al.
Published: (2020)
by: Caracelli, Ignez, et al.
Published: (2020)
Similar Items
-
Mechanism Of Action Of A Benzimidazole Sirtuin Inhibitor, Bzd9l1, In Colorectal Cancer
by: Tan, Yi Jer
Published: (2022) -
Ethyl 1-sec-butyl-2-phenyl-1H-benzimidazole-5-carboxylate
by: Arumugam, Natarajan, et al.
Published: (2010) -
Ethyl 1-(2-hydroxyethyl)-2-phenyl-1H-benzimidazole-5-carboxylate
by: Hamzah, Nurasyikin, et al.
Published: (2010) -
Ethyl 1-(butan-2-yl)-2-(2-methoxyphenyl)-
1H-benzimidazole-5-carboxylate
by: Natarajan, Arumugam, et al.
Published: (2011) -
Ethyl 1-(2-hydroxyethyl)-2-[2-(methylsulfanyl)ethyl]-1H-benzimidazole-5-carboxylate
by: Hamzah, Nurasyikin, et al.
Published: (2012)