Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application
A study was conducted to formulate a semi-solid SEDDS with enhanced bioavailability using Gelucire® 44/14 as the self-emulsifying agent and a tocotrienols mixture (EVNol™ 50%) as the liquid model drug. A series of formulations with different proportions of tocotrienol extract and Gelucire® 44/14 wer...
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| Format: | Thesis |
| Language: | English |
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2022
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| Online Access: | http://eprints.usm.my/59321/ http://eprints.usm.my/59321/1/24%20Pages%20from%20SYAZANA%20BINTI%20ABU%20BAKAR%20-%20TESIS.pdf |
| _version_ | 1848884138425188352 |
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| author | Abu Bakar, Syazana |
| author_facet | Abu Bakar, Syazana |
| author_sort | Abu Bakar, Syazana |
| building | USM Institutional Repository |
| collection | Online Access |
| description | A study was conducted to formulate a semi-solid SEDDS with enhanced bioavailability using Gelucire® 44/14 as the self-emulsifying agent and a tocotrienols mixture (EVNol™ 50%) as the liquid model drug. A series of formulations with different proportions of tocotrienol extract and Gelucire® 44/14 were prepared and evaluated. Finally, a formulation with 1:1 ratio of tocotrienols to Gelucire® 44/14 with the addition of 2.5% of propylene glycol was found most suitable to obtain a semi-solid SEDDS with satisfactory self-emulsifying properties. From a series of in vitro studies, the formulation was able to self-emulsify under gentle agitation and formed an oil in water emulsion within 3 minutes upon contact with the dissolution media. The emulsion formed was stable, with the emulsion particle size distribution achieving nano-range. Subsequently, |
| first_indexed | 2025-11-15T19:01:56Z |
| format | Thesis |
| id | usm-59321 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T19:01:56Z |
| publishDate | 2022 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-593212023-09-04T01:19:49Z http://eprints.usm.my/59321/ Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application Abu Bakar, Syazana RS1-441 Pharmacy and materia medica A study was conducted to formulate a semi-solid SEDDS with enhanced bioavailability using Gelucire® 44/14 as the self-emulsifying agent and a tocotrienols mixture (EVNol™ 50%) as the liquid model drug. A series of formulations with different proportions of tocotrienol extract and Gelucire® 44/14 were prepared and evaluated. Finally, a formulation with 1:1 ratio of tocotrienols to Gelucire® 44/14 with the addition of 2.5% of propylene glycol was found most suitable to obtain a semi-solid SEDDS with satisfactory self-emulsifying properties. From a series of in vitro studies, the formulation was able to self-emulsify under gentle agitation and formed an oil in water emulsion within 3 minutes upon contact with the dissolution media. The emulsion formed was stable, with the emulsion particle size distribution achieving nano-range. Subsequently, 2022-02 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/59321/1/24%20Pages%20from%20SYAZANA%20BINTI%20ABU%20BAKAR%20-%20TESIS.pdf Abu Bakar, Syazana (2022) Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application. PhD thesis, Perpustakaan Hamzah Sendut. |
| spellingShingle | RS1-441 Pharmacy and materia medica Abu Bakar, Syazana Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
| title | Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
| title_full | Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
| title_fullStr | Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
| title_full_unstemmed | Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
| title_short | Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
| title_sort | development of semi-solid self-emulsifying drug delivery system (sedds) using liquid model drug for oral drug delivery application |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/59321/ http://eprints.usm.my/59321/1/24%20Pages%20from%20SYAZANA%20BINTI%20ABU%20BAKAR%20-%20TESIS.pdf |