Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking
Background: White matter hyperintensity (WMH) is a common finding on T2 weighted MRI brain or CT Brain among the older subjects. There has been a recognized linkage between the development of Dementia and Alzheimer's disease. Technological advancements in recent years have made the understan...
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| Format: | Thesis |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | http://eprints.usm.my/58865/ http://eprints.usm.my/58865/1/MITCHELL%20MODI%20MIJOL-24%20pages.pdf |
| _version_ | 1848884015131525120 |
|---|---|
| author | Mijol, Mitchell Modi |
| author_facet | Mijol, Mitchell Modi |
| author_sort | Mijol, Mitchell Modi |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Background: White matter hyperintensity (WMH) is a common finding on T2
weighted MRI brain or CT Brain among the older subjects. There has been a
recognized linkage between the development of Dementia and Alzheimer's disease.
Technological advancements in recent years have made the understanding of the
pathogenesis of WMHs deeper, with several proposed mechanisms, focusing on
anatomy, blood-brain barrier disruption, cerebral blood flow autoregulation, venous
collagenases, and genetic factors. Smoking has been postulated to have an influence
on WMH in several reports.
Methods: A retrospective study was conducted in Hospital USM, Kota Bharu,
Malaysia with MRI brain of patient aged 18 years and above were reviewed. The MRI
must include both T2WI and FLAIR sequences. Patients with gross brain lesions,
structural abnormalities, and history suggestive ongoing intracranial infection,
inflammatory or demyelinating diseases were excluded. Demographic data regarding
pack-years, age of initiation/cessation, duration of smoking, type of cigarettes (nonfiltered,
filtered, e-cigarette) was collected and analysed using Pearson’s correlation
method, Fisher exact test, and Independent T-test as necessary.
Results: There was a significant association between age (p<0.001), smoking status
(p<0.001) especially in the ex-smoker and passive smoker group (p=0.022), and
comorbidities (p<0.001) with WMH. The mean age of participants in the WMH group
was higher than No WMH (p<0.001). For smoking status, a higher prevalence of non smoker was found in the No WMH group. There was a high percentage of participants
with no comorbidities reported to be in the No WMH group (n=80, 77.7%).
Conclusion: Significant association was found between age, smoking status (Exsmoker
and passive smoker), and co-morbidities with WMHs. |
| first_indexed | 2025-11-15T18:59:59Z |
| format | Thesis |
| id | usm-58865 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:59:59Z |
| publishDate | 2021 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-588652023-07-06T06:49:49Z http://eprints.usm.my/58865/ Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking Mijol, Mitchell Modi RC71-78.7 Examination. Diagnosis Including raiography Background: White matter hyperintensity (WMH) is a common finding on T2 weighted MRI brain or CT Brain among the older subjects. There has been a recognized linkage between the development of Dementia and Alzheimer's disease. Technological advancements in recent years have made the understanding of the pathogenesis of WMHs deeper, with several proposed mechanisms, focusing on anatomy, blood-brain barrier disruption, cerebral blood flow autoregulation, venous collagenases, and genetic factors. Smoking has been postulated to have an influence on WMH in several reports. Methods: A retrospective study was conducted in Hospital USM, Kota Bharu, Malaysia with MRI brain of patient aged 18 years and above were reviewed. The MRI must include both T2WI and FLAIR sequences. Patients with gross brain lesions, structural abnormalities, and history suggestive ongoing intracranial infection, inflammatory or demyelinating diseases were excluded. Demographic data regarding pack-years, age of initiation/cessation, duration of smoking, type of cigarettes (nonfiltered, filtered, e-cigarette) was collected and analysed using Pearson’s correlation method, Fisher exact test, and Independent T-test as necessary. Results: There was a significant association between age (p<0.001), smoking status (p<0.001) especially in the ex-smoker and passive smoker group (p=0.022), and comorbidities (p<0.001) with WMH. The mean age of participants in the WMH group was higher than No WMH (p<0.001). For smoking status, a higher prevalence of non smoker was found in the No WMH group. There was a high percentage of participants with no comorbidities reported to be in the No WMH group (n=80, 77.7%). Conclusion: Significant association was found between age, smoking status (Exsmoker and passive smoker), and co-morbidities with WMHs. 2021 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/58865/1/MITCHELL%20MODI%20MIJOL-24%20pages.pdf Mijol, Mitchell Modi (2021) Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RC71-78.7 Examination. Diagnosis Including raiography Mijol, Mitchell Modi Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking |
| title | Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking |
| title_full | Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking |
| title_fullStr | Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking |
| title_full_unstemmed | Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking |
| title_short | Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking |
| title_sort | association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking |
| topic | RC71-78.7 Examination. Diagnosis Including raiography |
| url | http://eprints.usm.my/58865/ http://eprints.usm.my/58865/1/MITCHELL%20MODI%20MIJOL-24%20pages.pdf |