Understanding the mechanism of actions of 1A calcidol on arterial stiffness, microvascular endothelial function, inflammation and proteinuria in Type 2 Diabetic patients with nephropathy
Introduction: Low vitamin D levels correlate with presence of cardiovascular diseases (CVD) in diabetics. Mechanism for the beneficial effects of vitamin D on CVD has not been fully explained. This study aimed to evaluate possible mechanisms for vitamin D effects on markers linked to CVD progressi...
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| Format: | Monograph |
| Language: | English |
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Universiti Sains Malaysia
2014
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| Online Access: | http://eprints.usm.my/58694/ http://eprints.usm.my/58694/1/DR.%20AIDA%20HANUM%20GHULAM%20RASOOL-Eprints.pdf |
| _version_ | 1848883967777832960 |
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| author | Rasool, Aida Hanum Ghulam |
| author_facet | Rasool, Aida Hanum Ghulam |
| author_sort | Rasool, Aida Hanum Ghulam |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Introduction: Low vitamin D levels correlate with presence of cardiovascular diseases (CVD) in diabetics.
Mechanism for the beneficial effects of vitamin D on CVD has not been fully explained. This study aimed to
evaluate possible mechanisms for vitamin D effects on markers linked to CVD progression. The effects of
vitamin D (as 1-alfacalcidol) in diabetic nephropathy patients on i) arterial stiffness ii) microvascular
endothelial function iii) inflammation iv) proteinuria were evaluated.
Methodology: A prospective randomized controlled study was conducted in diabetic nephropathy
patients. Vitamin D treated group (n=28) were given la calcidol 0.25 meg daily for 6 months, while control
patients (n=32) received standard treatment. Baseline measurements for vitamin D levels, hsCRP, arterial
stiffness, blood pressure (BP), microvascular endothelial function, renal function and albuminuria were
performed and repeated after 6 months.
Results and conclusion: After 6 months treatment with vitamin D, there was significant improvement in
arterial stiffness in vitamin D deficient patients. Significant reductions in central SBP, central pulse pressure
and peripheral SBP were also observed. Microvascular endothelial function was impaired in vitamin D
deficient diabetic nephropathy patients, however, 6 months treatment with 0.25 meg alfacalcidol did not
improve this parameter. Systemic inflammation increased after 6 months in controls patients but was not
seen in vitamin D treated patients. It appears that the effects of vitamin D on CV markers were more
apparent in vitamin D deficient diabetic nephropathy patients. Thus, vitamin D may be beneficial for CVD
via its effect of improving BP, arterial stiffness, microvascular function and delaying progression of
inflammation in diabetic nephropathy patients. |
| first_indexed | 2025-11-15T18:59:14Z |
| format | Monograph |
| id | usm-58694 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:59:14Z |
| publishDate | 2014 |
| publisher | Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-586942023-07-06T06:55:19Z http://eprints.usm.my/58694/ Understanding the mechanism of actions of 1A calcidol on arterial stiffness, microvascular endothelial function, inflammation and proteinuria in Type 2 Diabetic patients with nephropathy Rasool, Aida Hanum Ghulam R735-854 Medical education. Medical schools. Research RC648-665 Diseases of the endocrine glands. Clinical endocrinology Introduction: Low vitamin D levels correlate with presence of cardiovascular diseases (CVD) in diabetics. Mechanism for the beneficial effects of vitamin D on CVD has not been fully explained. This study aimed to evaluate possible mechanisms for vitamin D effects on markers linked to CVD progression. The effects of vitamin D (as 1-alfacalcidol) in diabetic nephropathy patients on i) arterial stiffness ii) microvascular endothelial function iii) inflammation iv) proteinuria were evaluated. Methodology: A prospective randomized controlled study was conducted in diabetic nephropathy patients. Vitamin D treated group (n=28) were given la calcidol 0.25 meg daily for 6 months, while control patients (n=32) received standard treatment. Baseline measurements for vitamin D levels, hsCRP, arterial stiffness, blood pressure (BP), microvascular endothelial function, renal function and albuminuria were performed and repeated after 6 months. Results and conclusion: After 6 months treatment with vitamin D, there was significant improvement in arterial stiffness in vitamin D deficient patients. Significant reductions in central SBP, central pulse pressure and peripheral SBP were also observed. Microvascular endothelial function was impaired in vitamin D deficient diabetic nephropathy patients, however, 6 months treatment with 0.25 meg alfacalcidol did not improve this parameter. Systemic inflammation increased after 6 months in controls patients but was not seen in vitamin D treated patients. It appears that the effects of vitamin D on CV markers were more apparent in vitamin D deficient diabetic nephropathy patients. Thus, vitamin D may be beneficial for CVD via its effect of improving BP, arterial stiffness, microvascular function and delaying progression of inflammation in diabetic nephropathy patients. Universiti Sains Malaysia 2014 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/58694/1/DR.%20AIDA%20HANUM%20GHULAM%20RASOOL-Eprints.pdf Rasool, Aida Hanum Ghulam (2014) Understanding the mechanism of actions of 1A calcidol on arterial stiffness, microvascular endothelial function, inflammation and proteinuria in Type 2 Diabetic patients with nephropathy. Project Report. Universiti Sains Malaysia. (Submitted) |
| spellingShingle | R735-854 Medical education. Medical schools. Research RC648-665 Diseases of the endocrine glands. Clinical endocrinology Rasool, Aida Hanum Ghulam Understanding the mechanism of actions of 1A calcidol on arterial stiffness, microvascular endothelial function, inflammation and proteinuria in Type 2 Diabetic patients with nephropathy |
| title | Understanding the mechanism of actions of 1A calcidol on arterial stiffness, microvascular endothelial function, inflammation and
proteinuria in Type 2 Diabetic patients with nephropathy |
| title_full | Understanding the mechanism of actions of 1A calcidol on arterial stiffness, microvascular endothelial function, inflammation and
proteinuria in Type 2 Diabetic patients with nephropathy |
| title_fullStr | Understanding the mechanism of actions of 1A calcidol on arterial stiffness, microvascular endothelial function, inflammation and
proteinuria in Type 2 Diabetic patients with nephropathy |
| title_full_unstemmed | Understanding the mechanism of actions of 1A calcidol on arterial stiffness, microvascular endothelial function, inflammation and
proteinuria in Type 2 Diabetic patients with nephropathy |
| title_short | Understanding the mechanism of actions of 1A calcidol on arterial stiffness, microvascular endothelial function, inflammation and
proteinuria in Type 2 Diabetic patients with nephropathy |
| title_sort | understanding the mechanism of actions of 1a calcidol on arterial stiffness, microvascular endothelial function, inflammation and
proteinuria in type 2 diabetic patients with nephropathy |
| topic | R735-854 Medical education. Medical schools. Research RC648-665 Diseases of the endocrine glands. Clinical endocrinology |
| url | http://eprints.usm.my/58694/ http://eprints.usm.my/58694/1/DR.%20AIDA%20HANUM%20GHULAM%20RASOOL-Eprints.pdf |