The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma
Introduction: Emergence of Programmed death 1 (PD-1) and its ligands, PD-L1 immunotherapy provide new insight in the treatment modality of malignancies. The responsiveness of the patients are associated with the expressions of the PD-L1 and PD-1 protein. We aimed to evaluate the expression of PD-...
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| Format: | Thesis |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | http://eprints.usm.my/58572/ http://eprints.usm.my/58572/1/FARHANA%20MOHAMMAD%20MOHAIDIN-24%20pages.pdf |
| _version_ | 1848883935041290240 |
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| author | Mohaidin, Farhana Mohammad |
| author_facet | Mohaidin, Farhana Mohammad |
| author_sort | Mohaidin, Farhana Mohammad |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Introduction: Emergence of Programmed death 1 (PD-1) and its ligands, PD-L1 immunotherapy
provide new insight in the treatment modality of malignancies. The responsiveness of the patients
are associated with the expressions of the PD-L1 and PD-1 protein. We aimed to evaluate the
expression of PD-1 in the tumour microenvironment and PD-L1 in the tumour cells with
histological subtypes of primary extranodal non-Hodgkin lymphoma (peNHL).
Methodology: A retrospective cross-sectional study using 87 archived formalin fixed paraffin-embedded
tissue blocks of patients diagnosed with peNHL. Samples were stained for PD-1 and
PD-L1 by immunohistochemistry method and the proteins expressions were evaluated
microscopically. The association between expression of the PD-1 and PD-L1 with subtypes of
peNHL were statistically analysed.
Results: Majority of the cases are negative expression of PD-L1 in the tumour cells (46, 52.9%),
however majority are positive for PD-1 expression in the tumour microenvironment (57, 65.5%).
Significant associations were found between PD-1 and PD-L1 expression with subtypes of peNHL
(p<0.05) and higher expression was found in DLBCL.
Conclusion: Our study, the first in Malaysia to explore expression of PD-1 and PD-L1 in peNHL,
demonstrates significant association of PD-1 and PD-L1 expressions with subtypes of peNHL
which may impact treatment of these patients in the future. |
| first_indexed | 2025-11-15T18:58:42Z |
| format | Thesis |
| id | usm-58572 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:58:42Z |
| publishDate | 2021 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-585722023-05-18T02:28:28Z http://eprints.usm.my/58572/ The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma Mohaidin, Farhana Mohammad RC Internal medicine Introduction: Emergence of Programmed death 1 (PD-1) and its ligands, PD-L1 immunotherapy provide new insight in the treatment modality of malignancies. The responsiveness of the patients are associated with the expressions of the PD-L1 and PD-1 protein. We aimed to evaluate the expression of PD-1 in the tumour microenvironment and PD-L1 in the tumour cells with histological subtypes of primary extranodal non-Hodgkin lymphoma (peNHL). Methodology: A retrospective cross-sectional study using 87 archived formalin fixed paraffin-embedded tissue blocks of patients diagnosed with peNHL. Samples were stained for PD-1 and PD-L1 by immunohistochemistry method and the proteins expressions were evaluated microscopically. The association between expression of the PD-1 and PD-L1 with subtypes of peNHL were statistically analysed. Results: Majority of the cases are negative expression of PD-L1 in the tumour cells (46, 52.9%), however majority are positive for PD-1 expression in the tumour microenvironment (57, 65.5%). Significant associations were found between PD-1 and PD-L1 expression with subtypes of peNHL (p<0.05) and higher expression was found in DLBCL. Conclusion: Our study, the first in Malaysia to explore expression of PD-1 and PD-L1 in peNHL, demonstrates significant association of PD-1 and PD-L1 expressions with subtypes of peNHL which may impact treatment of these patients in the future. 2021 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/58572/1/FARHANA%20MOHAMMAD%20MOHAIDIN-24%20pages.pdf Mohaidin, Farhana Mohammad (2021) The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RC Internal medicine Mohaidin, Farhana Mohammad The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma |
| title | The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma |
| title_full | The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma |
| title_fullStr | The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma |
| title_full_unstemmed | The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma |
| title_short | The evaluation of program death 1 and PD-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma |
| title_sort | evaluation of program death 1 and pd-1 ligand expressions in histological subtypes of primary extranodal non hodgkin lymphoma |
| topic | RC Internal medicine |
| url | http://eprints.usm.my/58572/ http://eprints.usm.my/58572/1/FARHANA%20MOHAMMAD%20MOHAIDIN-24%20pages.pdf |