Antitumor Effects of Madu Lebah Tualang on Human Leukemia Cell Line (K562)
Tualang Honey possesses as therapeutic potential in wound healing, antimicrobial activity and antiproliferative against several cancer model such as Oral Squamous Cell Carcinomas (OSCC), Human Osteosarcoma (HOS), human breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cell lines. The aim o...
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| Format: | Monograph |
| Language: | English |
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Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2016
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| Online Access: | http://eprints.usm.my/58158/ http://eprints.usm.my/58158/1/PROF%20DR%20ROSLINE%20HASSAN-Eprints.pdf |
| _version_ | 1848883822367604736 |
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| author | Hassan, Rosline |
| author_facet | Hassan, Rosline |
| author_sort | Hassan, Rosline |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Tualang Honey possesses as therapeutic potential in wound healing, antimicrobial activity and antiproliferative
against several cancer model such as Oral Squamous Cell Carcinomas (OSCC), Human
Osteosarcoma (HOS), human breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cell lines.
The aim of this study was to evaluate the apoptosis effect of natural local honey “Tualang Honey" on
leukemia cell line. In order to evaluate this effect, leukemia cell line (K562) and normal mononuclear
cell isolate from peripheral blood were grown in RPMI 1640 culture medium. Both cell lines were incubated with increasing concentrations of Tualang Honey for 24 hours at 37°C. After incubation,
they were evaluated for cytotoxicity and apoptotic activity. The IC 50 value against K562 cell line was
determined at 0.6% (18ul) after 24 hours. Apoptosis was seen in both K562 and mononuclear cell after
incubation with Tualang Honey. However the percentage of apoptosis was much higher with K562
compared to mononuclear cell. At the concentration of IC50 (0.6%>), Tualang Honey gave the 53.9°%
apoptosis activity to K562, as opposed to mononuclear cell (37.4°%) (p<0.05). Therefore Tualang
Honey is shown to be a potential anti-leukemic substance. |
| first_indexed | 2025-11-15T18:56:55Z |
| format | Monograph |
| id | usm-58158 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:56:55Z |
| publishDate | 2016 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-581582023-04-27T06:45:16Z http://eprints.usm.my/58158/ Antitumor Effects of Madu Lebah Tualang on Human Leukemia Cell Line (K562) Hassan, Rosline RM Therapeutics. Pharmacology Tualang Honey possesses as therapeutic potential in wound healing, antimicrobial activity and antiproliferative against several cancer model such as Oral Squamous Cell Carcinomas (OSCC), Human Osteosarcoma (HOS), human breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cell lines. The aim of this study was to evaluate the apoptosis effect of natural local honey “Tualang Honey" on leukemia cell line. In order to evaluate this effect, leukemia cell line (K562) and normal mononuclear cell isolate from peripheral blood were grown in RPMI 1640 culture medium. Both cell lines were incubated with increasing concentrations of Tualang Honey for 24 hours at 37°C. After incubation, they were evaluated for cytotoxicity and apoptotic activity. The IC 50 value against K562 cell line was determined at 0.6% (18ul) after 24 hours. Apoptosis was seen in both K562 and mononuclear cell after incubation with Tualang Honey. However the percentage of apoptosis was much higher with K562 compared to mononuclear cell. At the concentration of IC50 (0.6%>), Tualang Honey gave the 53.9°% apoptosis activity to K562, as opposed to mononuclear cell (37.4°%) (p<0.05). Therefore Tualang Honey is shown to be a potential anti-leukemic substance. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2016 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/58158/1/PROF%20DR%20ROSLINE%20HASSAN-Eprints.pdf Hassan, Rosline (2016) Antitumor Effects of Madu Lebah Tualang on Human Leukemia Cell Line (K562). Project Report. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia. (Submitted) |
| spellingShingle | RM Therapeutics. Pharmacology Hassan, Rosline Antitumor Effects of Madu Lebah Tualang on Human Leukemia Cell Line (K562) |
| title | Antitumor Effects of Madu Lebah Tualang on Human Leukemia Cell Line (K562) |
| title_full | Antitumor Effects of Madu Lebah Tualang on Human Leukemia Cell Line (K562) |
| title_fullStr | Antitumor Effects of Madu Lebah Tualang on Human Leukemia Cell Line (K562) |
| title_full_unstemmed | Antitumor Effects of Madu Lebah Tualang on Human Leukemia Cell Line (K562) |
| title_short | Antitumor Effects of Madu Lebah Tualang on Human Leukemia Cell Line (K562) |
| title_sort | antitumor effects of madu lebah tualang on human leukemia cell line (k562) |
| topic | RM Therapeutics. Pharmacology |
| url | http://eprints.usm.my/58158/ http://eprints.usm.my/58158/1/PROF%20DR%20ROSLINE%20HASSAN-Eprints.pdf |