A study of inhibition and reversal of plasmodium falciparum cytoadherence using RNA apatamer specific to ICAM-1 /CD54 and CD36 protein
Malaria is a life-threatening parasitic infection occurring in the endemic areas,. primarily in children under the age of five, pregnant women, and patients with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV) /(AIDS) as well as non-immune individuals. The cytoadherence...
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| Format: | Monograph |
| Language: | English |
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Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2018
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| Online Access: | http://eprints.usm.my/57015/ http://eprints.usm.my/57015/1/DR.%20KHAIRUL%20MOHO%20FADZLI%20MUSTAFFA%20-%2024%20pages.pdf |
| _version_ | 1848883511825530880 |
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| author | Mustaffa, Khairul Mohd Fadzli |
| author_facet | Mustaffa, Khairul Mohd Fadzli |
| author_sort | Mustaffa, Khairul Mohd Fadzli |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Malaria is a life-threatening parasitic infection occurring in the endemic areas,. primarily
in children under the age of five, pregnant women, and patients with human immunodeficiency
virus and acquired immunodeficiency syndrome (HIV) /(AIDS) as well as non-immune individuals.
The cytoadherence of infected erythrocytes (IEs) to the host endothelial surface receptor is a known
factor that contributes to the increased prevalence of severe malaria cases due to the accumulation of
!Es, mainly in the brain and other vital organs. Therefore, further study is needed to discover a new
potential anti-adhesive drug to treat severe malaria thus reducing its mortality rate. In this review,
we discuss how the aptamer technology could be applied in the development of a new adjunct
therapy for current malaria treatment. |
| first_indexed | 2025-11-15T18:51:59Z |
| format | Monograph |
| id | usm-57015 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:51:59Z |
| publishDate | 2018 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-570152023-03-01T08:01:19Z http://eprints.usm.my/57015/ A study of inhibition and reversal of plasmodium falciparum cytoadherence using RNA apatamer specific to ICAM-1 /CD54 and CD36 protein Mustaffa, Khairul Mohd Fadzli R Medicine RA643-645 Disease (Communicable and noninfectious) and public health Malaria is a life-threatening parasitic infection occurring in the endemic areas,. primarily in children under the age of five, pregnant women, and patients with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV) /(AIDS) as well as non-immune individuals. The cytoadherence of infected erythrocytes (IEs) to the host endothelial surface receptor is a known factor that contributes to the increased prevalence of severe malaria cases due to the accumulation of !Es, mainly in the brain and other vital organs. Therefore, further study is needed to discover a new potential anti-adhesive drug to treat severe malaria thus reducing its mortality rate. In this review, we discuss how the aptamer technology could be applied in the development of a new adjunct therapy for current malaria treatment. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2018 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/57015/1/DR.%20KHAIRUL%20MOHO%20FADZLI%20MUSTAFFA%20-%2024%20pages.pdf Mustaffa, Khairul Mohd Fadzli (2018) A study of inhibition and reversal of plasmodium falciparum cytoadherence using RNA apatamer specific to ICAM-1 /CD54 and CD36 protein. Project Report. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia. (Submitted) |
| spellingShingle | R Medicine RA643-645 Disease (Communicable and noninfectious) and public health Mustaffa, Khairul Mohd Fadzli A study of inhibition and reversal of plasmodium falciparum cytoadherence using RNA apatamer specific to ICAM-1 /CD54 and CD36 protein |
| title | A study of inhibition and reversal of plasmodium
falciparum cytoadherence using RNA apatamer
specific to ICAM-1 /CD54 and CD36 protein |
| title_full | A study of inhibition and reversal of plasmodium
falciparum cytoadherence using RNA apatamer
specific to ICAM-1 /CD54 and CD36 protein |
| title_fullStr | A study of inhibition and reversal of plasmodium
falciparum cytoadherence using RNA apatamer
specific to ICAM-1 /CD54 and CD36 protein |
| title_full_unstemmed | A study of inhibition and reversal of plasmodium
falciparum cytoadherence using RNA apatamer
specific to ICAM-1 /CD54 and CD36 protein |
| title_short | A study of inhibition and reversal of plasmodium
falciparum cytoadherence using RNA apatamer
specific to ICAM-1 /CD54 and CD36 protein |
| title_sort | study of inhibition and reversal of plasmodium
falciparum cytoadherence using rna apatamer
specific to icam-1 /cd54 and cd36 protein |
| topic | R Medicine RA643-645 Disease (Communicable and noninfectious) and public health |
| url | http://eprints.usm.my/57015/ http://eprints.usm.my/57015/1/DR.%20KHAIRUL%20MOHO%20FADZLI%20MUSTAFFA%20-%2024%20pages.pdf |