Bioactivity Improvement Of 45S5 Bioglass Through Calcium Coating
4555 bioactive glass (BG) has been utilized in clinical applications, especially in bone regeneration. However, BG has limited bioactivity that restricts its use in live tissue. Calcium treatment is used to promote the formation of the HA layer hence boost the bioactivity of the BG. The bioactivit...
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| Format: | Monograph |
| Language: | English |
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Universiti Sains Malaysia
2022
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| Online Access: | http://eprints.usm.my/56700/ http://eprints.usm.my/56700/1/Bioactivity%20Improvement%20Of%2045S5%20Bioglass%20Through%20Calcium%20Coating_Nurul%20Amirah%20Mahadi.pdf |
| _version_ | 1848883425698643968 |
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| author | Mahadi, Nurul Amirah |
| author_facet | Mahadi, Nurul Amirah |
| author_sort | Mahadi, Nurul Amirah |
| building | USM Institutional Repository |
| collection | Online Access |
| description | 4555 bioactive glass (BG) has been utilized in clinical applications, especially in bone regeneration. However, BG has limited bioactivity that restricts its use in live tissue. Calcium treatment is used to promote the formation of the HA
layer hence boost the bioactivity of the BG. The bioactivity was studied by varying the type of calcium salt which is calcium acetate, nitrate and chloride. BG 45S5,
having mole percentages (mol%) of 45% SiO2, 24.5% CaO, 24.5% Na2O, and 6% P2O5, was synthesized via a melt-derived method. Batching, mixing, melting at 1400 °C, water quenching, grinding, sieving, pressing, and sintering were all part
of the BG preparations. The BG were treated with calcium salt then subjected to simulated body fluid incubation to determine bioactivity for hydroxyl carbonate apatite (HCA) layer development, which was followed by characterisations.
Calcium acetate treated BG 45S5 had functional groups of P-O and C-O bonds, which contributed to the development of HCA layers. The pH value was determined by analyzing SBF after each immersion period. Calcium acetate treated showed the
growth of the HCA layer on the surface as the pH value almost constant for 7 days of immersion among other calcium salts. The weight loss measurement also indicate that BG that treated with calcium acetate has the significant weight loss
that shows bioglass dissolution followed by calcium chloride and calcium nitrate. It shows the effectiveness of soluble ion dissociation into the SBF solution. |
| first_indexed | 2025-11-15T18:50:37Z |
| format | Monograph |
| id | usm-56700 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:50:37Z |
| publishDate | 2022 |
| publisher | Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-567002023-01-31T08:55:14Z http://eprints.usm.my/56700/ Bioactivity Improvement Of 45S5 Bioglass Through Calcium Coating Mahadi, Nurul Amirah T Technology TN Mining Engineering. Metallurgy 4555 bioactive glass (BG) has been utilized in clinical applications, especially in bone regeneration. However, BG has limited bioactivity that restricts its use in live tissue. Calcium treatment is used to promote the formation of the HA layer hence boost the bioactivity of the BG. The bioactivity was studied by varying the type of calcium salt which is calcium acetate, nitrate and chloride. BG 45S5, having mole percentages (mol%) of 45% SiO2, 24.5% CaO, 24.5% Na2O, and 6% P2O5, was synthesized via a melt-derived method. Batching, mixing, melting at 1400 °C, water quenching, grinding, sieving, pressing, and sintering were all part of the BG preparations. The BG were treated with calcium salt then subjected to simulated body fluid incubation to determine bioactivity for hydroxyl carbonate apatite (HCA) layer development, which was followed by characterisations. Calcium acetate treated BG 45S5 had functional groups of P-O and C-O bonds, which contributed to the development of HCA layers. The pH value was determined by analyzing SBF after each immersion period. Calcium acetate treated showed the growth of the HCA layer on the surface as the pH value almost constant for 7 days of immersion among other calcium salts. The weight loss measurement also indicate that BG that treated with calcium acetate has the significant weight loss that shows bioglass dissolution followed by calcium chloride and calcium nitrate. It shows the effectiveness of soluble ion dissociation into the SBF solution. Universiti Sains Malaysia 2022-08-01 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/56700/1/Bioactivity%20Improvement%20Of%2045S5%20Bioglass%20Through%20Calcium%20Coating_Nurul%20Amirah%20Mahadi.pdf Mahadi, Nurul Amirah (2022) Bioactivity Improvement Of 45S5 Bioglass Through Calcium Coating. Project Report. Universiti Sains Malaysia, Pusat Pengajian Kejuruteraan Bahan dan Sumber Mineral. (Submitted) |
| spellingShingle | T Technology TN Mining Engineering. Metallurgy Mahadi, Nurul Amirah Bioactivity Improvement Of 45S5 Bioglass Through Calcium Coating |
| title | Bioactivity Improvement Of 45S5 Bioglass Through Calcium Coating |
| title_full | Bioactivity Improvement Of 45S5 Bioglass Through Calcium Coating |
| title_fullStr | Bioactivity Improvement Of 45S5 Bioglass Through Calcium Coating |
| title_full_unstemmed | Bioactivity Improvement Of 45S5 Bioglass Through Calcium Coating |
| title_short | Bioactivity Improvement Of 45S5 Bioglass Through Calcium Coating |
| title_sort | bioactivity improvement of 45s5 bioglass through calcium coating |
| topic | T Technology TN Mining Engineering. Metallurgy |
| url | http://eprints.usm.my/56700/ http://eprints.usm.my/56700/1/Bioactivity%20Improvement%20Of%2045S5%20Bioglass%20Through%20Calcium%20Coating_Nurul%20Amirah%20Mahadi.pdf |