The effects of combination behavioural intervention of nutritional education and exercise (combine) on oxidate stress markers in obese subject
Alterations in the levels of oxidative stress and haemostatic markers have been proposed as one of the mechanisms for obesity-related cardiovascular disease. This study aims to evaluate the effect of 12-week behavioral lifestyle modification program on the oxidative stress levels in obese subject...
| Main Author: | |
|---|---|
| Format: | Monograph |
| Language: | English |
| Published: |
Pusat Pengajian Sains Perubatan
2012
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/55647/ http://eprints.usm.my/55647/1/DR.%20RAHIMAH%20ZAKARIA%20-%20e.pdf |
| _version_ | 1848883139734142976 |
|---|---|
| author | Rahimah, Zakaria |
| author_facet | Rahimah, Zakaria |
| author_sort | Rahimah, Zakaria |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Alterations in the levels of oxidative stress and haemostatic markers have
been proposed as one of the mechanisms for obesity-related cardiovascular
disease. This study aims to evaluate the effect of 12-week behavioral lifestyle
modification program on the oxidative stress levels in obese subjects. This is
an interventional prospective study conducted from April 2009 through
December 2010. Thirty four obese adult recruited from the Obesity Clinic,
Hospital Universiti Sains Malaysia participated in the 12-week behavioral
lifestyle modification program consisting of diet and exercise interventions.
Body weight, BMI and body fat were significantly reduced after 12-week
interventions. Plasma GPx activity and 4-HNE concentration increased
significantly after 12-week interventions. Other enzymatic antioxidant activities
such as CAT and SOD increased, and GSH:GSSG ratio reduced but the
changes were not statistically significant. Plasma fibrinogen, factor VII, TAFI,
t-PA and PAI-1 levels were significantly decreased and plasma Heparin
Cofactor II level was significantly increased after 12-week intervention. In
conclusion, diet and exercise interventions reduce cardiovascular risk factors
by reducing body fat, increasing enzymatic antioxidant defense and
beneficially altering the levels of haemostatic markers in obese adults. |
| first_indexed | 2025-11-15T18:46:04Z |
| format | Monograph |
| id | usm-55647 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:46:04Z |
| publishDate | 2012 |
| publisher | Pusat Pengajian Sains Perubatan |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-556472022-11-15T03:49:46Z http://eprints.usm.my/55647/ The effects of combination behavioural intervention of nutritional education and exercise (combine) on oxidate stress markers in obese subject Rahimah, Zakaria R Medicine (General) Alterations in the levels of oxidative stress and haemostatic markers have been proposed as one of the mechanisms for obesity-related cardiovascular disease. This study aims to evaluate the effect of 12-week behavioral lifestyle modification program on the oxidative stress levels in obese subjects. This is an interventional prospective study conducted from April 2009 through December 2010. Thirty four obese adult recruited from the Obesity Clinic, Hospital Universiti Sains Malaysia participated in the 12-week behavioral lifestyle modification program consisting of diet and exercise interventions. Body weight, BMI and body fat were significantly reduced after 12-week interventions. Plasma GPx activity and 4-HNE concentration increased significantly after 12-week interventions. Other enzymatic antioxidant activities such as CAT and SOD increased, and GSH:GSSG ratio reduced but the changes were not statistically significant. Plasma fibrinogen, factor VII, TAFI, t-PA and PAI-1 levels were significantly decreased and plasma Heparin Cofactor II level was significantly increased after 12-week intervention. In conclusion, diet and exercise interventions reduce cardiovascular risk factors by reducing body fat, increasing enzymatic antioxidant defense and beneficially altering the levels of haemostatic markers in obese adults. Pusat Pengajian Sains Perubatan 2012 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/55647/1/DR.%20RAHIMAH%20ZAKARIA%20-%20e.pdf Rahimah, Zakaria (2012) The effects of combination behavioural intervention of nutritional education and exercise (combine) on oxidate stress markers in obese subject. Other. Pusat Pengajian Sains Perubatan. (Submitted) |
| spellingShingle | R Medicine (General) Rahimah, Zakaria The effects of combination behavioural intervention of nutritional education and exercise (combine) on oxidate stress markers in obese subject |
| title | The effects of combination behavioural
intervention of nutritional education and
exercise (combine) on oxidate stress markers
in obese subject |
| title_full | The effects of combination behavioural
intervention of nutritional education and
exercise (combine) on oxidate stress markers
in obese subject |
| title_fullStr | The effects of combination behavioural
intervention of nutritional education and
exercise (combine) on oxidate stress markers
in obese subject |
| title_full_unstemmed | The effects of combination behavioural
intervention of nutritional education and
exercise (combine) on oxidate stress markers
in obese subject |
| title_short | The effects of combination behavioural
intervention of nutritional education and
exercise (combine) on oxidate stress markers
in obese subject |
| title_sort | effects of combination behavioural
intervention of nutritional education and
exercise (combine) on oxidate stress markers
in obese subject |
| topic | R Medicine (General) |
| url | http://eprints.usm.my/55647/ http://eprints.usm.my/55647/1/DR.%20RAHIMAH%20ZAKARIA%20-%20e.pdf |