Contributions of TGFJ31 and SMAD4 genes to the etiology of keloid scars in the Malay population
Background: Keloid scars are complex dermal condition with genetic and environmental contributing factors. TGF(3 and SMAD candidate genes, which are located in the same signaling pathway, are highly expressed in the keloid fibroblast cells. To date, only few documented reports showing relationshi...
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| Format: | Monograph |
| Language: | English |
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Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia
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| Subjects: | |
| Online Access: | http://eprints.usm.my/54747/ http://eprints.usm.my/54747/1/DR%20KHOO%20TENG%20LYE-Eprints.pdf |
| _version_ | 1848882891231068160 |
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| author | Khoo, Teng Lye |
| author_facet | Khoo, Teng Lye |
| author_sort | Khoo, Teng Lye |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Background: Keloid scars are complex dermal condition with genetic and environmental
contributing factors. TGF(3 and SMAD candidate genes, which are located in the same
signaling pathway, are highly expressed in the keloid fibroblast cells. To date, only few
documented reports showing relationship between TGF(31 and keloid in Caucasian
population but none on SMAD4.
Purpose: The contributions of TGF(31 and SMAD4 in the keloid formation of Malay population
were studies.
Subjects and Methodology: The DNAs were extracted from the blood samples of 1 00 Malay
patients with keloids with another 100 healthy individuals without keloids as controls. The
DNAs were analyzed via Polymerase Chain Reaction and single-nucleotide polymorphism
genotyping.
Results: TGF(31 halotypes showed a strong association with the risk of keloid formation. The
CC halotypes of TGF(31, composed of both c.29C>T and -509T>C variants, showed higher
frequency among keloid patients compared with the controls (11% versus 2.7%, corrected
p=0.037), showing 4.5-fold increased risk for keloid formation. The c.5131A>G variant of
SMAD4 revealed a statistically significant trend (p=0.0573). Taken together, either of these
variants is the most probable causative factor at the expression level or is in linkage
disequilibrium with other causative variants in a complex pattern with the environmental
factors, contributing to keloid formation.
Conclusion: This is the first study documenting strong positive association between TGF(31
and SMAD4 variants and keloid formation in the Malay population. |
| first_indexed | 2025-11-15T18:42:07Z |
| format | Monograph |
| id | usm-54747 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:42:07Z |
| publisher | Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-547472022-09-18T08:38:38Z http://eprints.usm.my/54747/ Contributions of TGFJ31 and SMAD4 genes to the etiology of keloid scars in the Malay population Khoo, Teng Lye R Medicine Background: Keloid scars are complex dermal condition with genetic and environmental contributing factors. TGF(3 and SMAD candidate genes, which are located in the same signaling pathway, are highly expressed in the keloid fibroblast cells. To date, only few documented reports showing relationship between TGF(31 and keloid in Caucasian population but none on SMAD4. Purpose: The contributions of TGF(31 and SMAD4 in the keloid formation of Malay population were studies. Subjects and Methodology: The DNAs were extracted from the blood samples of 1 00 Malay patients with keloids with another 100 healthy individuals without keloids as controls. The DNAs were analyzed via Polymerase Chain Reaction and single-nucleotide polymorphism genotyping. Results: TGF(31 halotypes showed a strong association with the risk of keloid formation. The CC halotypes of TGF(31, composed of both c.29C>T and -509T>C variants, showed higher frequency among keloid patients compared with the controls (11% versus 2.7%, corrected p=0.037), showing 4.5-fold increased risk for keloid formation. The c.5131A>G variant of SMAD4 revealed a statistically significant trend (p=0.0573). Taken together, either of these variants is the most probable causative factor at the expression level or is in linkage disequilibrium with other causative variants in a complex pattern with the environmental factors, contributing to keloid formation. Conclusion: This is the first study documenting strong positive association between TGF(31 and SMAD4 variants and keloid formation in the Malay population. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/54747/1/DR%20KHOO%20TENG%20LYE-Eprints.pdf Khoo, Teng Lye Contributions of TGFJ31 and SMAD4 genes to the etiology of keloid scars in the Malay population. Other. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia. |
| spellingShingle | R Medicine Khoo, Teng Lye Contributions of TGFJ31 and SMAD4 genes to the etiology of keloid scars in the Malay population |
| title | Contributions of TGFJ31 and SMAD4 genes to the etiology of keloid scars in
the Malay population |
| title_full | Contributions of TGFJ31 and SMAD4 genes to the etiology of keloid scars in
the Malay population |
| title_fullStr | Contributions of TGFJ31 and SMAD4 genes to the etiology of keloid scars in
the Malay population |
| title_full_unstemmed | Contributions of TGFJ31 and SMAD4 genes to the etiology of keloid scars in
the Malay population |
| title_short | Contributions of TGFJ31 and SMAD4 genes to the etiology of keloid scars in
the Malay population |
| title_sort | contributions of tgfj31 and smad4 genes to the etiology of keloid scars in
the malay population |
| topic | R Medicine |
| url | http://eprints.usm.my/54747/ http://eprints.usm.my/54747/1/DR%20KHOO%20TENG%20LYE-Eprints.pdf |