Reducing the occurrence of shivering with intravenous dexmedetomidine in patients undergoing caesarean delivery under spinal anaesthesia : a double-blinded, randomised controlled trial of the efficacy and safety
Background Shivering is a very discomforting experience following spinal anaesthesia, especially in patients undergoing caesarean delivery. The objective of this study was to investigate the efficacy and safety of intravenous (IV) dexmedetomidine in preventing shivering in patients undergoing ca...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2019
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/53502/ http://eprints.usm.my/53502/1/Wan%20Ahmad%20Asyraf%20Wan%20Md%20Adnan-24%20pages.pdf |
| _version_ | 1848882547120930816 |
|---|---|
| author | Adnan, Wan Ahmad Asyraf Wan Md |
| author_facet | Adnan, Wan Ahmad Asyraf Wan Md |
| author_sort | Adnan, Wan Ahmad Asyraf Wan Md |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Background
Shivering is a very discomforting experience following spinal anaesthesia, especially in
patients undergoing caesarean delivery. The objective of this study was to investigate the
efficacy and safety of intravenous (IV) dexmedetomidine in preventing shivering in
patients undergoing caesarean delivery under spinal anaesthesia.
Methods
This was a prospective, double-blind, randomized trial involving 62 parturients
undergoing caesarean delivery under spinal anaesthesia. They were divided into 2 groups;
patients in group D (dexmedetomidine, n = 31) received 0.5mcg/kg IV dexmedetomidine
over 10 minutes followed by infusion of 0.4mcg/kg/hr until end of surgery; whilst patients
in group C (saline, n = 31) received equivalent loading and infusion volume of 0.9%
saline. The occurrence of shivering, sedation score and haemodynamic parameters were
recorded intraoperatively.
Results
The occurrence of shivering was significantly reduced in group D as compared to group
C (3.2% vs 64.5%, p < 0.001). Patients in group D were more sedated as compared to
group C (51.6% vs 0%, p < 0.001). There were no statistically significant difference in
systolic and diastolic blood pressure between both groups. Heart rate in group D were
significantly lower than group C but still within normal physiological range.
Conclusion
IV dexmedetomidine was effective in reducing the occurrence of shivering but with
significant sedative effect and lowering of heart rate than placebo. However, the value of
heart rate was still within normal range. |
| first_indexed | 2025-11-15T18:36:39Z |
| format | Thesis |
| id | usm-53502 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:36:39Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-535022022-07-21T04:19:27Z http://eprints.usm.my/53502/ Reducing the occurrence of shivering with intravenous dexmedetomidine in patients undergoing caesarean delivery under spinal anaesthesia : a double-blinded, randomised controlled trial of the efficacy and safety Adnan, Wan Ahmad Asyraf Wan Md R Medicine Background Shivering is a very discomforting experience following spinal anaesthesia, especially in patients undergoing caesarean delivery. The objective of this study was to investigate the efficacy and safety of intravenous (IV) dexmedetomidine in preventing shivering in patients undergoing caesarean delivery under spinal anaesthesia. Methods This was a prospective, double-blind, randomized trial involving 62 parturients undergoing caesarean delivery under spinal anaesthesia. They were divided into 2 groups; patients in group D (dexmedetomidine, n = 31) received 0.5mcg/kg IV dexmedetomidine over 10 minutes followed by infusion of 0.4mcg/kg/hr until end of surgery; whilst patients in group C (saline, n = 31) received equivalent loading and infusion volume of 0.9% saline. The occurrence of shivering, sedation score and haemodynamic parameters were recorded intraoperatively. Results The occurrence of shivering was significantly reduced in group D as compared to group C (3.2% vs 64.5%, p < 0.001). Patients in group D were more sedated as compared to group C (51.6% vs 0%, p < 0.001). There were no statistically significant difference in systolic and diastolic blood pressure between both groups. Heart rate in group D were significantly lower than group C but still within normal physiological range. Conclusion IV dexmedetomidine was effective in reducing the occurrence of shivering but with significant sedative effect and lowering of heart rate than placebo. However, the value of heart rate was still within normal range. 2019 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/53502/1/Wan%20Ahmad%20Asyraf%20Wan%20Md%20Adnan-24%20pages.pdf Adnan, Wan Ahmad Asyraf Wan Md (2019) Reducing the occurrence of shivering with intravenous dexmedetomidine in patients undergoing caesarean delivery under spinal anaesthesia : a double-blinded, randomised controlled trial of the efficacy and safety. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R Medicine Adnan, Wan Ahmad Asyraf Wan Md Reducing the occurrence of shivering with intravenous dexmedetomidine in patients undergoing caesarean delivery under spinal anaesthesia : a double-blinded, randomised controlled trial of the efficacy and safety |
| title | Reducing the occurrence of shivering with intravenous dexmedetomidine in patients undergoing caesarean delivery under spinal anaesthesia : a double-blinded, randomised controlled trial of the efficacy and safety |
| title_full | Reducing the occurrence of shivering with intravenous dexmedetomidine in patients undergoing caesarean delivery under spinal anaesthesia : a double-blinded, randomised controlled trial of the efficacy and safety |
| title_fullStr | Reducing the occurrence of shivering with intravenous dexmedetomidine in patients undergoing caesarean delivery under spinal anaesthesia : a double-blinded, randomised controlled trial of the efficacy and safety |
| title_full_unstemmed | Reducing the occurrence of shivering with intravenous dexmedetomidine in patients undergoing caesarean delivery under spinal anaesthesia : a double-blinded, randomised controlled trial of the efficacy and safety |
| title_short | Reducing the occurrence of shivering with intravenous dexmedetomidine in patients undergoing caesarean delivery under spinal anaesthesia : a double-blinded, randomised controlled trial of the efficacy and safety |
| title_sort | reducing the occurrence of shivering with intravenous dexmedetomidine in patients undergoing caesarean delivery under spinal anaesthesia : a double-blinded, randomised controlled trial of the efficacy and safety |
| topic | R Medicine |
| url | http://eprints.usm.my/53502/ http://eprints.usm.my/53502/1/Wan%20Ahmad%20Asyraf%20Wan%20Md%20Adnan-24%20pages.pdf |