Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methot...
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| Format: | Thesis |
| Language: | English |
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2020
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| Online Access: | http://eprints.usm.my/53495/ http://eprints.usm.my/53495/1/MOHAMMAD%20GASEM%20MOHAMMAD%20ALTHIABAT%20-%20TESIS.pdf%20cut.pdf |
| _version_ | 1848882545100324864 |
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| author | Althiabat, Mohammad Gasem Mohammad |
| author_facet | Althiabat, Mohammad Gasem Mohammad |
| author_sort | Althiabat, Mohammad Gasem Mohammad |
| building | USM Institutional Repository |
| collection | Online Access |
| description | The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methotrexate (MTX) and the parent folic acid (FA) towards FRα. |
| first_indexed | 2025-11-15T18:36:37Z |
| format | Thesis |
| id | usm-53495 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:36:37Z |
| publishDate | 2020 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-534952022-07-21T01:53:26Z http://eprints.usm.my/53495/ Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity Althiabat, Mohammad Gasem Mohammad RS1-441 Pharmacy and materia medica The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methotrexate (MTX) and the parent folic acid (FA) towards FRα. 2020-10 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/53495/1/MOHAMMAD%20GASEM%20MOHAMMAD%20ALTHIABAT%20-%20TESIS.pdf%20cut.pdf Althiabat, Mohammad Gasem Mohammad (2020) Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Althiabat, Mohammad Gasem Mohammad Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity |
| title | Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity |
| title_full | Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity |
| title_fullStr | Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity |
| title_full_unstemmed | Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity |
| title_short | Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity |
| title_sort | rational drug design of new folic acid analogues with high binding affinity and anticancer activity |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/53495/ http://eprints.usm.my/53495/1/MOHAMMAD%20GASEM%20MOHAMMAD%20ALTHIABAT%20-%20TESIS.pdf%20cut.pdf |