Fabrication Of Porous Β_TCP Scaffold Via Freeze Drying Method
Beta-tricalcium phosphate (β-TCP) has been widely used for biomedical application. There are several methods to fabricate porous scaffolds including solvent casting, phase separation, rapid prototyping and electrospinning methods. In the present study, β-TCP scaffolds and alginate coated β-TCP scaff...
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| Format: | Monograph |
| Language: | English |
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Universiti Sains Malaysia
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| Online Access: | http://eprints.usm.my/52515/ http://eprints.usm.my/52515/1/Fabrication%20Of%20Porous%20%CE%92_TCP%20Scaffold%20Via%20Freeze%20Drying%20Method_Nurul%20Fatin%20Nabila%20Ismail_B1_20.pdf |
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| author | Ismail, Nurul Fatin Nabila |
| author_facet | Ismail, Nurul Fatin Nabila |
| author_sort | Ismail, Nurul Fatin Nabila |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Beta-tricalcium phosphate (β-TCP) has been widely used for biomedical application. There are several methods to fabricate porous scaffolds including solvent casting, phase separation, rapid prototyping and electrospinning methods. In the present study, β-TCP scaffolds and alginate coated β-TCP scaffolds were fabricated using freeze drying method. β-TCP slurry was frozen and freeze dried for 24 hours followed by sintering process to form β-TCP scaffolds. The porous β-TCP scaffold were fabricated at different percentages of β-TCP powder used (10 wt%, 20 wt% and 30 wt%) and froze at different freezing temperature (-10°C, -20°C, -40°C and -80°C), in order to study the effect of these parameters on the pore formation of the scaffolds. Scanning electron microscopy (SEM) analysis for 30 wt% β-TCP scaffold frozen at -10°C revealed acceptable pore size distribution with majority pore size within the range of 102.65 μm to 372.90 μm. Furthermore, this scaffold also possessed highest compressive strength of 0.31 MPa. In order to investigate the effect of alginate coating on mechanical properties, 30 wt% β-TCP scaffold at freezing temperature of -10°C was selected to be impregnated with 5% of sodium alginate. After coating was completely done, Fourier transformed infrared spectroscopy (FTIR) analysis and SEM analysis were done. FTIR analysis identifies the existence of sodium alginate functional groups while SEM observation shows smoother surface. Compression test analysis shows that with the coating of sodium alginate on the -TCP scaffold increased in the compression strength value to 0.8 MPa from 0.31 MPa were obtained. |
| first_indexed | 2025-11-15T18:32:21Z |
| format | Monograph |
| id | usm-52515 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:32:21Z |
| publisher | Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-525152022-05-18T04:31:26Z http://eprints.usm.my/52515/ Fabrication Of Porous Β_TCP Scaffold Via Freeze Drying Method Ismail, Nurul Fatin Nabila T Technology TA401-492 Materials of engineering and construction. Mechanics of materials Beta-tricalcium phosphate (β-TCP) has been widely used for biomedical application. There are several methods to fabricate porous scaffolds including solvent casting, phase separation, rapid prototyping and electrospinning methods. In the present study, β-TCP scaffolds and alginate coated β-TCP scaffolds were fabricated using freeze drying method. β-TCP slurry was frozen and freeze dried for 24 hours followed by sintering process to form β-TCP scaffolds. The porous β-TCP scaffold were fabricated at different percentages of β-TCP powder used (10 wt%, 20 wt% and 30 wt%) and froze at different freezing temperature (-10°C, -20°C, -40°C and -80°C), in order to study the effect of these parameters on the pore formation of the scaffolds. Scanning electron microscopy (SEM) analysis for 30 wt% β-TCP scaffold frozen at -10°C revealed acceptable pore size distribution with majority pore size within the range of 102.65 μm to 372.90 μm. Furthermore, this scaffold also possessed highest compressive strength of 0.31 MPa. In order to investigate the effect of alginate coating on mechanical properties, 30 wt% β-TCP scaffold at freezing temperature of -10°C was selected to be impregnated with 5% of sodium alginate. After coating was completely done, Fourier transformed infrared spectroscopy (FTIR) analysis and SEM analysis were done. FTIR analysis identifies the existence of sodium alginate functional groups while SEM observation shows smoother surface. Compression test analysis shows that with the coating of sodium alginate on the -TCP scaffold increased in the compression strength value to 0.8 MPa from 0.31 MPa were obtained. Universiti Sains Malaysia Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/52515/1/Fabrication%20Of%20Porous%20%CE%92_TCP%20Scaffold%20Via%20Freeze%20Drying%20Method_Nurul%20Fatin%20Nabila%20Ismail_B1_20.pdf Ismail, Nurul Fatin Nabila Fabrication Of Porous Β_TCP Scaffold Via Freeze Drying Method. Project Report. Universiti Sains Malaysia, Pusat Pengajian Kejuruteraan Bahan Sumber Mineral. (Submitted) |
| spellingShingle | T Technology TA401-492 Materials of engineering and construction. Mechanics of materials Ismail, Nurul Fatin Nabila Fabrication Of Porous Β_TCP Scaffold Via Freeze Drying Method |
| title | Fabrication Of Porous Β_TCP Scaffold Via Freeze Drying Method |
| title_full | Fabrication Of Porous Β_TCP Scaffold Via Freeze Drying Method |
| title_fullStr | Fabrication Of Porous Β_TCP Scaffold Via Freeze Drying Method |
| title_full_unstemmed | Fabrication Of Porous Β_TCP Scaffold Via Freeze Drying Method |
| title_short | Fabrication Of Porous Β_TCP Scaffold Via Freeze Drying Method |
| title_sort | fabrication of porous β_tcp scaffold via freeze drying method |
| topic | T Technology TA401-492 Materials of engineering and construction. Mechanics of materials |
| url | http://eprints.usm.my/52515/ http://eprints.usm.my/52515/1/Fabrication%20Of%20Porous%20%CE%92_TCP%20Scaffold%20Via%20Freeze%20Drying%20Method_Nurul%20Fatin%20Nabila%20Ismail_B1_20.pdf |