Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment
Titanium dioxide nanoparticles (TiO2 NPs) have been proven to be a potential candidate in cancer therapy, particularly in the application of photodynamic therapy (PDT). However, the application of TiO2 NPs is limited due to the fast recombination rate of electron (e-)/hole (h+) pairs attributed to t...
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| Format: | Thesis |
| Language: | English |
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2021
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| Online Access: | http://eprints.usm.my/52488/ http://eprints.usm.my/52488/1/PRAVENA%20AP%20RAMACHANDRAN.pdf |
| _version_ | 1848882270347198464 |
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| author | Ramachandran, Pravena |
| author_facet | Ramachandran, Pravena |
| author_sort | Ramachandran, Pravena |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Titanium dioxide nanoparticles (TiO2 NPs) have been proven to be a potential candidate in cancer therapy, particularly in the application of photodynamic therapy (PDT). However, the application of TiO2 NPs is limited due to the fast recombination rate of electron (e-)/hole (h+) pairs attributed to their wider bandgap energy. Thus, surface modification is explored to shift the absorption edge to a longer light wavelength to allow penetration into deep-seated tumours. In this study, TiO2 NPs conjugated with N-doped graphene quantum dots composites (N-GQDs/TiO2 NCs) to extend the light absorption properties of TiO2 to longer near-infrared (NIR) wavelengths. A facile one-pot hydrothermal method was employed to synthesise N-GQDs with an average particle size of 4.40 ± 1.5 nm at optimum conditions with molar ratio citric acid (CA):ethylenediamine (EDA) (1:1) at 180 °C for 4 h and primary amine (EDA) as the N-precursors. The blue emissive N-GQDs have photoluminescence (PL) quantum yield of 80.2 %, exhibited excitation-independent PL emission at 442 nm, with an excitation wavelength of 340 nm. Whereas, the anatase TiO2 NPs were synthesised using microwave-assisted synthesis in the aqueous phase with an average particle size of 11.46 ± 2.8 nm, a small crystallite size (12.2 nm) and low bandgap energy (2.93 eV). |
| first_indexed | 2025-11-15T18:32:15Z |
| format | Thesis |
| id | usm-52488 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:32:15Z |
| publishDate | 2021 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-524882022-05-10T07:27:07Z http://eprints.usm.my/52488/ Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment Ramachandran, Pravena QD1-999 Chemistry Titanium dioxide nanoparticles (TiO2 NPs) have been proven to be a potential candidate in cancer therapy, particularly in the application of photodynamic therapy (PDT). However, the application of TiO2 NPs is limited due to the fast recombination rate of electron (e-)/hole (h+) pairs attributed to their wider bandgap energy. Thus, surface modification is explored to shift the absorption edge to a longer light wavelength to allow penetration into deep-seated tumours. In this study, TiO2 NPs conjugated with N-doped graphene quantum dots composites (N-GQDs/TiO2 NCs) to extend the light absorption properties of TiO2 to longer near-infrared (NIR) wavelengths. A facile one-pot hydrothermal method was employed to synthesise N-GQDs with an average particle size of 4.40 ± 1.5 nm at optimum conditions with molar ratio citric acid (CA):ethylenediamine (EDA) (1:1) at 180 °C for 4 h and primary amine (EDA) as the N-precursors. The blue emissive N-GQDs have photoluminescence (PL) quantum yield of 80.2 %, exhibited excitation-independent PL emission at 442 nm, with an excitation wavelength of 340 nm. Whereas, the anatase TiO2 NPs were synthesised using microwave-assisted synthesis in the aqueous phase with an average particle size of 11.46 ± 2.8 nm, a small crystallite size (12.2 nm) and low bandgap energy (2.93 eV). 2021-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/52488/1/PRAVENA%20AP%20RAMACHANDRAN.pdf Ramachandran, Pravena (2021) Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment. Masters thesis, Perpustakaan Hamzah Sendut. |
| spellingShingle | QD1-999 Chemistry Ramachandran, Pravena Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment |
| title | Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment |
| title_full | Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment |
| title_fullStr | Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment |
| title_full_unstemmed | Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment |
| title_short | Synthesis And Characterisation Of N-Doped Graphene Quantum Dots/Titanium Dioxide Nanocomposite As Photosensitiser In Photodynamic Therapy For Breast Cancer Treatment |
| title_sort | synthesis and characterisation of n-doped graphene quantum dots/titanium dioxide nanocomposite as photosensitiser in photodynamic therapy for breast cancer treatment |
| topic | QD1-999 Chemistry |
| url | http://eprints.usm.my/52488/ http://eprints.usm.my/52488/1/PRAVENA%20AP%20RAMACHANDRAN.pdf |