Drug Release Study Of PLA Microspheres Loaded With Gentamicin
Poly(lactic acid) (PLA) microspheres were fabricated through emulsion and solvent evaporation (ESE) technique. PLA loaded with different concentration of gentamicin were immersed in 0.5M NaOH solutions for 48 hours. The concentration of gentamicin were used are 0.125 %, 0.25 % and 0.375 %. Treated P...
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| Format: | Monograph |
| Language: | English |
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Universiti Sains Malaysia
2017
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| Online Access: | http://eprints.usm.my/52393/ http://eprints.usm.my/52393/1/Drug%20Release%20Study%20Of%20PLA%20Microspheres%20Loaded%20With%20Gentamicin_Nur%20Afiqah%20Hamat_B1_2017.pdf |
| _version_ | 1848882245269454848 |
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| author | Hamat, Nur Afiqah |
| author_facet | Hamat, Nur Afiqah |
| author_sort | Hamat, Nur Afiqah |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Poly(lactic acid) (PLA) microspheres were fabricated through emulsion and solvent evaporation (ESE) technique. PLA loaded with different concentration of gentamicin were immersed in 0.5M NaOH solutions for 48 hours. The concentration of gentamicin were used are 0.125 %, 0.25 % and 0.375 %. Treated PLA microspheres were investigated using several characterization methods including Fourier Transform InfraRed (FTIR), Scanning Electron Microscopy (SEM), Particle size analysis, Contact Angle and Ultraviolet (UV) visible spectroscopy. The peak of gentamicin was determined and confirmed by FTIR. The treated PLA microspheres has becomes rough and porous surface after surface hydrolysis treatment. SEM proved the surface morphology changes of surface modified PLA microspheres. The value of contact angle was less than 90° after surface hydrolysis treatment and confirmed the improved hydrophilicity properties of surface modified PLA microspheres. The percentage of encapsulation efficiency (% EE) of gentamicin within PLA microspheres was evaluated by using UV-vis spectroscopy. The results recorded that higher concentration of gentamicin, which is 0.375 % gentamicin has the higher encapsulation efficiency around 15.22 %. The drug release of gentamicin from PLA microspheres showed the burst-effect manner within first 8 hours. After that, the drug release rate was slow and sustained release for the remainder days monitoring period. |
| first_indexed | 2025-11-15T18:31:51Z |
| format | Monograph |
| id | usm-52393 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:31:51Z |
| publishDate | 2017 |
| publisher | Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-523932022-04-22T03:43:31Z http://eprints.usm.my/52393/ Drug Release Study Of PLA Microspheres Loaded With Gentamicin Hamat, Nur Afiqah T Technology TA401-492 Materials of engineering and construction. Mechanics of materials Poly(lactic acid) (PLA) microspheres were fabricated through emulsion and solvent evaporation (ESE) technique. PLA loaded with different concentration of gentamicin were immersed in 0.5M NaOH solutions for 48 hours. The concentration of gentamicin were used are 0.125 %, 0.25 % and 0.375 %. Treated PLA microspheres were investigated using several characterization methods including Fourier Transform InfraRed (FTIR), Scanning Electron Microscopy (SEM), Particle size analysis, Contact Angle and Ultraviolet (UV) visible spectroscopy. The peak of gentamicin was determined and confirmed by FTIR. The treated PLA microspheres has becomes rough and porous surface after surface hydrolysis treatment. SEM proved the surface morphology changes of surface modified PLA microspheres. The value of contact angle was less than 90° after surface hydrolysis treatment and confirmed the improved hydrophilicity properties of surface modified PLA microspheres. The percentage of encapsulation efficiency (% EE) of gentamicin within PLA microspheres was evaluated by using UV-vis spectroscopy. The results recorded that higher concentration of gentamicin, which is 0.375 % gentamicin has the higher encapsulation efficiency around 15.22 %. The drug release of gentamicin from PLA microspheres showed the burst-effect manner within first 8 hours. After that, the drug release rate was slow and sustained release for the remainder days monitoring period. Universiti Sains Malaysia 2017-06-01 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/52393/1/Drug%20Release%20Study%20Of%20PLA%20Microspheres%20Loaded%20With%20Gentamicin_Nur%20Afiqah%20Hamat_B1_2017.pdf Hamat, Nur Afiqah (2017) Drug Release Study Of PLA Microspheres Loaded With Gentamicin. Project Report. Universiti Sains Malaysia, Pusat Pengajian Kejuruteraan Bahan Sumber Mineral. (Submitted) |
| spellingShingle | T Technology TA401-492 Materials of engineering and construction. Mechanics of materials Hamat, Nur Afiqah Drug Release Study Of PLA Microspheres Loaded With Gentamicin |
| title | Drug Release Study Of PLA Microspheres Loaded With Gentamicin |
| title_full | Drug Release Study Of PLA Microspheres Loaded With Gentamicin |
| title_fullStr | Drug Release Study Of PLA Microspheres Loaded With Gentamicin |
| title_full_unstemmed | Drug Release Study Of PLA Microspheres Loaded With Gentamicin |
| title_short | Drug Release Study Of PLA Microspheres Loaded With Gentamicin |
| title_sort | drug release study of pla microspheres loaded with gentamicin |
| topic | T Technology TA401-492 Materials of engineering and construction. Mechanics of materials |
| url | http://eprints.usm.my/52393/ http://eprints.usm.my/52393/1/Drug%20Release%20Study%20Of%20PLA%20Microspheres%20Loaded%20With%20Gentamicin_Nur%20Afiqah%20Hamat_B1_2017.pdf |