Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines

Curcuma caesia, Curcuma aeruginosa and Dioscorea bulbifera are used traditionally for the treatment of human ailments including cancer. The present study was carried out to search for antimigratory compounds from C. caesia, C. aeruginosa rhizomes and D. bulbifera tubers using breast cancer cell l...

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Main Author:	Al-Amin, Md
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/51998/ http://eprints.usm.my/51998/1/MD%20AL-AMIN%20-%20TESIS.pdf

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author	Al-Amin, Md
author_facet	Al-Amin, Md
author_sort	Al-Amin, Md
building	USM Institutional Repository
collection	Online Access
description	Curcuma caesia, Curcuma aeruginosa and Dioscorea bulbifera are used traditionally for the treatment of human ailments including cancer. The present study was carried out to search for antimigratory compounds from C. caesia, C. aeruginosa rhizomes and D. bulbifera tubers using breast cancer cell lines. The chemical constituents from C. caesia and C. aeruginosa rhizomes have been isolated through fractionation. The extracts of C. caesia and C. aeruginosa rhizomes showed concentration-dependent inhibition of MCF-7 and MDA-MB-231 cells. Further study showed that hexane and chloroform fractions of C. caesia rhizomes and chloroform fraction of C. aeruginosa rhizomes are the bioactive fractions that significantly inhibit the viability of breast cancer cells. The chromatographic separation afforded germacrone (1), zerumbone (2), furanodienone (3), curzerenone (4), curcumenol (5), zederone (6), curcumenone (7) and dehydrocurdione (8) from hexane fraction and curcuminol G (9), curcuzederone (10), (1S, 10S), (4S,5S)-germacrone-1(10), 4- diepoxide (11), wenyujinin B (12), alismoxide (13), aerugidiol (14), zedoarolide B (15), zedoalactone B (16) zedoarondiol (17) and isozedoarondiol (18) from chloroform fraction of C. caesia rhizomes. The chromatographic separation afforded germacrone (1), furanodienone (3), curzerenone (4), curcumenol (5) and zederone (6) from chloroform fraction of C. aeruginosa. Cell viability assay of these isolated compounds further revealed that compounds 1-4 and 10, and compounds 1, 3 and 4 are the bioactive compounds of C. caesia and C. aeruginosa, respectively.
first_indexed	2025-11-15T18:30:10Z
format	Thesis
id	usm-51998
institution	Universiti Sains Malaysia
institution_category	Local University
language	English
last_indexed	2025-11-15T18:30:10Z
publishDate	2021
recordtype	eprints
repository_type	Digital Repository
spelling	usm-519982022-03-22T07:27:15Z http://eprints.usm.my/51998/ Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines Al-Amin, Md RS1-441 Pharmacy and materia medica Curcuma caesia, Curcuma aeruginosa and Dioscorea bulbifera are used traditionally for the treatment of human ailments including cancer. The present study was carried out to search for antimigratory compounds from C. caesia, C. aeruginosa rhizomes and D. bulbifera tubers using breast cancer cell lines. The chemical constituents from C. caesia and C. aeruginosa rhizomes have been isolated through fractionation. The extracts of C. caesia and C. aeruginosa rhizomes showed concentration-dependent inhibition of MCF-7 and MDA-MB-231 cells. Further study showed that hexane and chloroform fractions of C. caesia rhizomes and chloroform fraction of C. aeruginosa rhizomes are the bioactive fractions that significantly inhibit the viability of breast cancer cells. The chromatographic separation afforded germacrone (1), zerumbone (2), furanodienone (3), curzerenone (4), curcumenol (5), zederone (6), curcumenone (7) and dehydrocurdione (8) from hexane fraction and curcuminol G (9), curcuzederone (10), (1S, 10S), (4S,5S)-germacrone-1(10), 4- diepoxide (11), wenyujinin B (12), alismoxide (13), aerugidiol (14), zedoarolide B (15), zedoalactone B (16) zedoarondiol (17) and isozedoarondiol (18) from chloroform fraction of C. caesia rhizomes. The chromatographic separation afforded germacrone (1), furanodienone (3), curzerenone (4), curcumenol (5) and zederone (6) from chloroform fraction of C. aeruginosa. Cell viability assay of these isolated compounds further revealed that compounds 1-4 and 10, and compounds 1, 3 and 4 are the bioactive compounds of C. caesia and C. aeruginosa, respectively. 2021-04 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/51998/1/MD%20AL-AMIN%20-%20TESIS.pdf Al-Amin, Md (2021) Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines. Masters thesis, Perpustakaan Hamzah Sendut.
spellingShingle	RS1-441 Pharmacy and materia medica Al-Amin, Md Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title	Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title_full	Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title_fullStr	Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title_full_unstemmed	Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title_short	Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title_sort	isolation of antimigratory chemical constituents from curcuma caesia, curcuma aeruginosa rhizomes and dioscorea bulbifera tubers using human breast cancer cell lines
topic	RS1-441 Pharmacy and materia medica
url	http://eprints.usm.my/51998/ http://eprints.usm.my/51998/1/MD%20AL-AMIN%20-%20TESIS.pdf

Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines

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