Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis
Giardiasis is a disease caused by protozoan parasite Giardia intestinalis. Herein, we sought to examine the role of alpha-giardins in response to hydrogen peroxide (H202) treatment in G. intestinalis. Results showed that Giard1a treated with increased concentration of H20 2 demonstrated significa...
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| Format: | Article |
| Language: | English |
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Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2019
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| Online Access: | http://eprints.usm.my/51603/ http://eprints.usm.my/51603/1/DR.%20CHUAH%20CANDY-Eprints.pdf |
| _version_ | 1848882030876557312 |
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| author | Candy, Chuah |
| author_facet | Candy, Chuah |
| author_sort | Candy, Chuah |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Giardiasis is a disease caused by protozoan parasite Giardia intestinalis. Herein, we sought to
examine the role of alpha-giardins in response to hydrogen peroxide (H202) treatment in G.
intestinalis. Results showed that Giard1a treated with increased concentration of H20 2
demonstrated significant reduction in cell viability and significant increase reactive oxygen
species production. We found that alpha-2 and alpha-3 giardin showed significant up-regulated
transcriptional expression in H,O,-treated Giardia at 1 h time-point, whereas gene expression
level of alpha-7.2 and alpha-7.3 giardin up-regulated significantly at 4h time-point Alpha-11
giardin demonstrated up-regulated gene expression at a later time-point (8h and 24h) in H,02-
treated Giardia. Together these findings suggest that alpha giardins could serve as potential
promising target for future drug design and vaccine development |
| first_indexed | 2025-11-15T18:28:26Z |
| format | Article |
| id | usm-51603 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:28:26Z |
| publishDate | 2019 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-516032022-02-22T01:52:49Z http://eprints.usm.my/51603/ Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis Candy, Chuah R Medicine Giardiasis is a disease caused by protozoan parasite Giardia intestinalis. Herein, we sought to examine the role of alpha-giardins in response to hydrogen peroxide (H202) treatment in G. intestinalis. Results showed that Giard1a treated with increased concentration of H20 2 demonstrated significant reduction in cell viability and significant increase reactive oxygen species production. We found that alpha-2 and alpha-3 giardin showed significant up-regulated transcriptional expression in H,O,-treated Giardia at 1 h time-point, whereas gene expression level of alpha-7.2 and alpha-7.3 giardin up-regulated significantly at 4h time-point Alpha-11 giardin demonstrated up-regulated gene expression at a later time-point (8h and 24h) in H,02- treated Giardia. Together these findings suggest that alpha giardins could serve as potential promising target for future drug design and vaccine development Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2019 Article NonPeerReviewed application/pdf en http://eprints.usm.my/51603/1/DR.%20CHUAH%20CANDY-Eprints.pdf Candy, Chuah (2019) Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis. Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis. |
| spellingShingle | R Medicine Candy, Chuah Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis |
| title | Elucidating the roles of annexin-like molecules in
the protozoan parasite giardia intestinalis: an
approach to the control of giardiasis |
| title_full | Elucidating the roles of annexin-like molecules in
the protozoan parasite giardia intestinalis: an
approach to the control of giardiasis |
| title_fullStr | Elucidating the roles of annexin-like molecules in
the protozoan parasite giardia intestinalis: an
approach to the control of giardiasis |
| title_full_unstemmed | Elucidating the roles of annexin-like molecules in
the protozoan parasite giardia intestinalis: an
approach to the control of giardiasis |
| title_short | Elucidating the roles of annexin-like molecules in
the protozoan parasite giardia intestinalis: an
approach to the control of giardiasis |
| title_sort | elucidating the roles of annexin-like molecules in
the protozoan parasite giardia intestinalis: an
approach to the control of giardiasis |
| topic | R Medicine |
| url | http://eprints.usm.my/51603/ http://eprints.usm.my/51603/1/DR.%20CHUAH%20CANDY-Eprints.pdf |