Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis
Giardiasis is a disease caused by protozoan parasite Giardia intestinalis. Herein, we sought to examine the role of alpha-giardins in response to hydrogen peroxide (H202) treatment in G. intestinalis. Results showed that Giard1a treated with increased concentration of H20 2 demonstrated significa...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2019
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/51603/ http://eprints.usm.my/51603/1/DR.%20CHUAH%20CANDY-Eprints.pdf |
| Summary: | Giardiasis is a disease caused by protozoan parasite Giardia intestinalis. Herein, we sought to
examine the role of alpha-giardins in response to hydrogen peroxide (H202) treatment in G.
intestinalis. Results showed that Giard1a treated with increased concentration of H20 2
demonstrated significant reduction in cell viability and significant increase reactive oxygen
species production. We found that alpha-2 and alpha-3 giardin showed significant up-regulated
transcriptional expression in H,O,-treated Giardia at 1 h time-point, whereas gene expression
level of alpha-7.2 and alpha-7.3 giardin up-regulated significantly at 4h time-point Alpha-11
giardin demonstrated up-regulated gene expression at a later time-point (8h and 24h) in H,02-
treated Giardia. Together these findings suggest that alpha giardins could serve as potential
promising target for future drug design and vaccine development |
|---|