Metoclopramide for milk production in lactating women: a systematic review and meta-analysis
Background: Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological development of infants and is considered the most significant way to prevent child mortality. This study aimed to assess the effectiveness of metoclopramide for enhancing milk production in l...
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| Format: | Article |
| Language: | English |
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Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2021
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| Online Access: | http://eprints.usm.my/50910/ http://eprints.usm.my/50910/1/2021%20SRMA%20Metochlor%20Lactating%20KJFM-Eprints.pdf |
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| author | Hussain, Nik Hazlina Nik Noor, Norhayati Mohd Ismail, Saiful Bahari Zainuddin, Nur Amirah Sulaiman, Zaharah |
| author_facet | Hussain, Nik Hazlina Nik Noor, Norhayati Mohd Ismail, Saiful Bahari Zainuddin, Nur Amirah Sulaiman, Zaharah |
| author_sort | Hussain, Nik Hazlina Nik |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Background: Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological development
of infants and is considered the most significant way to prevent child mortality. This study aimed to assess
the effectiveness of metoclopramide for enhancing milk production in lactating women.
Methods: We searched the Cochrane Central Register of Controlled Trials and MEDLINE for randomized controlled
trials comparing metoclopramide with a placebo, no treatment, or other galactagogue drugs. We included
breastfeeding women with term or preterm infants.
Results: We retrieved 164 records from our search of the electronic databases and 20 records from other sources.
Eight trials involving 342 lactating women that used metoclopramide were included in this review after assessing
the eligibility criteria. The meta-analysis of these trials revealed that metoclopramide did not increase the milk volume
of the intervention groups compared to that of the control groups. There was a significant increase in the serum
concentrations of prolactin when the mothers were administered metoclopramide. No significant adverse
events were reported.
Conclusion: Metoclopramide did not improve milk production in lactating women. Therefore, we do not recommend
using metoclopramide to increase milk production in lactating women. |
| first_indexed | 2025-11-15T18:25:31Z |
| format | Article |
| id | usm-50910 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:25:31Z |
| publishDate | 2021 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-509102021-12-19T07:12:01Z http://eprints.usm.my/50910/ Metoclopramide for milk production in lactating women: a systematic review and meta-analysis Hussain, Nik Hazlina Nik Noor, Norhayati Mohd Ismail, Saiful Bahari Zainuddin, Nur Amirah Sulaiman, Zaharah R Medicine Background: Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological development of infants and is considered the most significant way to prevent child mortality. This study aimed to assess the effectiveness of metoclopramide for enhancing milk production in lactating women. Methods: We searched the Cochrane Central Register of Controlled Trials and MEDLINE for randomized controlled trials comparing metoclopramide with a placebo, no treatment, or other galactagogue drugs. We included breastfeeding women with term or preterm infants. Results: We retrieved 164 records from our search of the electronic databases and 20 records from other sources. Eight trials involving 342 lactating women that used metoclopramide were included in this review after assessing the eligibility criteria. The meta-analysis of these trials revealed that metoclopramide did not increase the milk volume of the intervention groups compared to that of the control groups. There was a significant increase in the serum concentrations of prolactin when the mothers were administered metoclopramide. No significant adverse events were reported. Conclusion: Metoclopramide did not improve milk production in lactating women. Therefore, we do not recommend using metoclopramide to increase milk production in lactating women. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2021 Article NonPeerReviewed application/pdf en http://eprints.usm.my/50910/1/2021%20SRMA%20Metochlor%20Lactating%20KJFM-Eprints.pdf Hussain, Nik Hazlina Nik and Noor, Norhayati Mohd and Ismail, Saiful Bahari and Zainuddin, Nur Amirah and Sulaiman, Zaharah (2021) Metoclopramide for milk production in lactating women: a systematic review and meta-analysis. Background: Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological development of infants and is considered the most significant way to prevent child mortality. This study aimed to assess the effectiveness of metocl. (Submitted) |
| spellingShingle | R Medicine Hussain, Nik Hazlina Nik Noor, Norhayati Mohd Ismail, Saiful Bahari Zainuddin, Nur Amirah Sulaiman, Zaharah Metoclopramide for milk production in lactating women: a systematic review and meta-analysis |
| title | Metoclopramide for milk production in
lactating women: a systematic review and meta-analysis |
| title_full | Metoclopramide for milk production in
lactating women: a systematic review and meta-analysis |
| title_fullStr | Metoclopramide for milk production in
lactating women: a systematic review and meta-analysis |
| title_full_unstemmed | Metoclopramide for milk production in
lactating women: a systematic review and meta-analysis |
| title_short | Metoclopramide for milk production in
lactating women: a systematic review and meta-analysis |
| title_sort | metoclopramide for milk production in
lactating women: a systematic review and meta-analysis |
| topic | R Medicine |
| url | http://eprints.usm.my/50910/ http://eprints.usm.my/50910/1/2021%20SRMA%20Metochlor%20Lactating%20KJFM-Eprints.pdf |