Hypervariable segment-! (HVS-I) Sequence Analysis Of Chinese Population of Peninsular Malaysia
Throughout Malaysia history, most of the Peninsular Malaysian Chinese are known to be populated by those migrated from the China during the British colonial era (Barbie, 1992). The present study was undertaken to obtain information about the distribution of the existing HVS-1 sequence variations...
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| Format: | Monograph |
| Language: | English |
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PPSP, Universiti Sains Malaysia
2007
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| Online Access: | http://eprints.usm.my/50207/ http://eprints.usm.my/50207/1/LEE%20LOONG%20CHUEN%20-%2024%20pages.pdf |
| _version_ | 1848881659339866112 |
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| author | Lee Loong, Chuen |
| author_facet | Lee Loong, Chuen |
| author_sort | Lee Loong, Chuen |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Throughout Malaysia history, most of the Peninsular Malaysian Chinese are known to
be populated by those migrated from the China during the British colonial era (Barbie, 1992).
The present study was undertaken to obtain information about the distribution of the existing
HVS-1 sequence variations in the Chinese population of Peninsular Malaysia. A few studies
have used RFLP analysis to characterize the mtDNA of Malaysian Chinese (Ismail, 2006;
Mokhtaruddin, 2006; Ballinger et al., 1992). The primary purpose of this study is to provide
HVS-1 sequence data by sequencing the HVS-1 of the 40 Chinese individuals from different
parts of Peninsular Malaysia. The secondary purpose is classification of mtDNA haplogroup
based on the HVS-1 sequence variation by alignment of samples sequence and Cambridge
Reference Sequence (CRS) (Andrew et al., 1999).
The samples were predicted to belong to the superhaplogroup M and haplogroup B in
relatively high frequency as inferred from the study done by Ballinger et al., (1992). Analysis
of HVS-1 within the control region (CR) of the mitochondrial genome revealed the presence
of eight haplogroups: B, F, M, MC, MD, MG, N, and R. These haplogroups are the
characteristics of Southeast Asian populations (Ballinger et al., 1992) and also found in
significant proportion in Han Chinese of China (Y ao et al., 2002). Result shows that
superhaplogroup M (includes MC, MD, and MG) is the most common haplogroup in the
studied samples (55%), followed by haplogroup B (18%). |
| first_indexed | 2025-11-15T18:22:32Z |
| format | Monograph |
| id | usm-50207 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:22:32Z |
| publishDate | 2007 |
| publisher | PPSP, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-502072021-10-11T02:48:28Z http://eprints.usm.my/50207/ Hypervariable segment-! (HVS-I) Sequence Analysis Of Chinese Population of Peninsular Malaysia Lee Loong, Chuen R Medicine (General) Throughout Malaysia history, most of the Peninsular Malaysian Chinese are known to be populated by those migrated from the China during the British colonial era (Barbie, 1992). The present study was undertaken to obtain information about the distribution of the existing HVS-1 sequence variations in the Chinese population of Peninsular Malaysia. A few studies have used RFLP analysis to characterize the mtDNA of Malaysian Chinese (Ismail, 2006; Mokhtaruddin, 2006; Ballinger et al., 1992). The primary purpose of this study is to provide HVS-1 sequence data by sequencing the HVS-1 of the 40 Chinese individuals from different parts of Peninsular Malaysia. The secondary purpose is classification of mtDNA haplogroup based on the HVS-1 sequence variation by alignment of samples sequence and Cambridge Reference Sequence (CRS) (Andrew et al., 1999). The samples were predicted to belong to the superhaplogroup M and haplogroup B in relatively high frequency as inferred from the study done by Ballinger et al., (1992). Analysis of HVS-1 within the control region (CR) of the mitochondrial genome revealed the presence of eight haplogroups: B, F, M, MC, MD, MG, N, and R. These haplogroups are the characteristics of Southeast Asian populations (Ballinger et al., 1992) and also found in significant proportion in Han Chinese of China (Y ao et al., 2002). Result shows that superhaplogroup M (includes MC, MD, and MG) is the most common haplogroup in the studied samples (55%), followed by haplogroup B (18%). PPSP, Universiti Sains Malaysia 2007-04 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/50207/1/LEE%20LOONG%20CHUEN%20-%2024%20pages.pdf Lee Loong, Chuen (2007) Hypervariable segment-! (HVS-I) Sequence Analysis Of Chinese Population of Peninsular Malaysia. Other. PPSP, Universiti Sains Malaysia. (Submitted) |
| spellingShingle | R Medicine (General) Lee Loong, Chuen Hypervariable segment-! (HVS-I) Sequence Analysis Of Chinese Population of Peninsular Malaysia |
| title | Hypervariable segment-! (HVS-I) Sequence Analysis
Of Chinese Population of Peninsular Malaysia |
| title_full | Hypervariable segment-! (HVS-I) Sequence Analysis
Of Chinese Population of Peninsular Malaysia |
| title_fullStr | Hypervariable segment-! (HVS-I) Sequence Analysis
Of Chinese Population of Peninsular Malaysia |
| title_full_unstemmed | Hypervariable segment-! (HVS-I) Sequence Analysis
Of Chinese Population of Peninsular Malaysia |
| title_short | Hypervariable segment-! (HVS-I) Sequence Analysis
Of Chinese Population of Peninsular Malaysia |
| title_sort | hypervariable segment-! (hvs-i) sequence analysis
of chinese population of peninsular malaysia |
| topic | R Medicine (General) |
| url | http://eprints.usm.my/50207/ http://eprints.usm.my/50207/1/LEE%20LOONG%20CHUEN%20-%2024%20pages.pdf |