Anti-CCP antibodies: A Better Diagnostic Tool for Rheumatoid Arthritis
Introduction: Rheumatoid factors are currently used in the diagnosis of rheumatoid arthritis and constitute one of the classification criteria proposed by the American College of Rheumatology. However, rheumatoid factor positivity shows low diagnostic specificity because rheumatoid factor because...
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| Format: | Article |
| Language: | English |
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Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2009
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| Online Access: | http://eprints.usm.my/48706/ http://eprints.usm.my/48706/1/DR.%20CHE%20MARINA%20BT.%20CHE%20HUSSIN-24%20pages.pdf |
| _version_ | 1848881230641102848 |
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| author | Hussin, Che Maraina Che |
| author_facet | Hussin, Che Maraina Che |
| author_sort | Hussin, Che Maraina Che |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Introduction: Rheumatoid factors are currently used in the diagnosis of rheumatoid
arthritis and constitute one of the classification criteria proposed by the American
College of Rheumatology. However, rheumatoid factor positivity shows low diagnostic
specificity because rheumatoid factor because it is also present in patients with other
autoimmune and infectious disease and even in a proportion of normal healthy
individuals. Recently, another test of interest in the diagnosis of rheumatoid arthritis is
the assay for anti-cyclic citrullinated peptide (anti-CCP) antibodies.
Objectives : To determine the sensitivity and specificity of anti-cyclic citrullinated
peptide antibodies in rheumatoid arthritis patients attending HUSM using American
College of rheumatology (ACR) criteria as a gold standard and to compare the
sensitivity and specificity of anti-CCP and rheumatoid factor.
Methodology: This was a cross sectional study which conducted from January 2008 to
December 2008. The study consisted of 253 patients, 100 patients with rheumatoid
arthritis and 153 patients with arthritis or arthralgia but not fulfilled ACR criteria for
rheumatoid arthritis. Serum from each subject was tested for anti-CCP antibodies and
lgG RF by enzyme linked immunosorbent assay. Sensitivity and specificity of the test
were evaluated using the clinical diagnosis as the gold standard.
Results: The sensitivity of anti-CCP was 71.0% with 93.8% of specificity. For
rheumatoid factor the sensitivity was 85.0% and specificity was 74.5%. The positive
predictive value for anti-CCP was 89.9% whereas for rheumatoid factor was 68.5%.
The sensitivity and specificity of anti-CCP antibodies and rheumatoid factor was
significantly different with p-value of< 0.001.
Conclusions: Anti-CCP antibody has a higher diagnostic specificity and positive
predictive value than rheumatoid factor, however sensitivity was lower than rheumatoid
factor . |
| first_indexed | 2025-11-15T18:15:43Z |
| format | Article |
| id | usm-48706 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:15:43Z |
| publishDate | 2009 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-487062021-03-28T02:18:14Z http://eprints.usm.my/48706/ Anti-CCP antibodies: A Better Diagnostic Tool for Rheumatoid Arthritis Hussin, Che Maraina Che R Medicine Introduction: Rheumatoid factors are currently used in the diagnosis of rheumatoid arthritis and constitute one of the classification criteria proposed by the American College of Rheumatology. However, rheumatoid factor positivity shows low diagnostic specificity because rheumatoid factor because it is also present in patients with other autoimmune and infectious disease and even in a proportion of normal healthy individuals. Recently, another test of interest in the diagnosis of rheumatoid arthritis is the assay for anti-cyclic citrullinated peptide (anti-CCP) antibodies. Objectives : To determine the sensitivity and specificity of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis patients attending HUSM using American College of rheumatology (ACR) criteria as a gold standard and to compare the sensitivity and specificity of anti-CCP and rheumatoid factor. Methodology: This was a cross sectional study which conducted from January 2008 to December 2008. The study consisted of 253 patients, 100 patients with rheumatoid arthritis and 153 patients with arthritis or arthralgia but not fulfilled ACR criteria for rheumatoid arthritis. Serum from each subject was tested for anti-CCP antibodies and lgG RF by enzyme linked immunosorbent assay. Sensitivity and specificity of the test were evaluated using the clinical diagnosis as the gold standard. Results: The sensitivity of anti-CCP was 71.0% with 93.8% of specificity. For rheumatoid factor the sensitivity was 85.0% and specificity was 74.5%. The positive predictive value for anti-CCP was 89.9% whereas for rheumatoid factor was 68.5%. The sensitivity and specificity of anti-CCP antibodies and rheumatoid factor was significantly different with p-value of< 0.001. Conclusions: Anti-CCP antibody has a higher diagnostic specificity and positive predictive value than rheumatoid factor, however sensitivity was lower than rheumatoid factor . Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2009 Article NonPeerReviewed application/pdf en http://eprints.usm.my/48706/1/DR.%20CHE%20MARINA%20BT.%20CHE%20HUSSIN-24%20pages.pdf Hussin, Che Maraina Che (2009) Anti-CCP antibodies: A Better Diagnostic Tool for Rheumatoid Arthritis. Anti-CCP antibodies: A Better Diagnostic Tool for Rheumatoid Arthritis. (Submitted) |
| spellingShingle | R Medicine Hussin, Che Maraina Che Anti-CCP antibodies: A Better Diagnostic Tool for Rheumatoid Arthritis |
| title | Anti-CCP antibodies: A Better Diagnostic Tool for Rheumatoid Arthritis |
| title_full | Anti-CCP antibodies: A Better Diagnostic Tool for Rheumatoid Arthritis |
| title_fullStr | Anti-CCP antibodies: A Better Diagnostic Tool for Rheumatoid Arthritis |
| title_full_unstemmed | Anti-CCP antibodies: A Better Diagnostic Tool for Rheumatoid Arthritis |
| title_short | Anti-CCP antibodies: A Better Diagnostic Tool for Rheumatoid Arthritis |
| title_sort | anti-ccp antibodies: a better diagnostic tool for rheumatoid arthritis |
| topic | R Medicine |
| url | http://eprints.usm.my/48706/ http://eprints.usm.my/48706/1/DR.%20CHE%20MARINA%20BT.%20CHE%20HUSSIN-24%20pages.pdf |