Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women

Depletion of estrogen production and secretion in postmenopausal women may lead to rapid bone loss and decreased bone mineral density (BMD). Decreased systemic BMD may also affect oral bone particularly mandibular bone resorption. Although several environmental factors influence bone loss, geneti...

Full description

Bibliographic Details
Main Author:	Rehman, Asia
Format:	Monograph
Language:	English
Published:	Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia 2006
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/47879/ http://eprints.usm.my/47879/1/DR.%20ASIA%20REHMAN-Abstract.pdf

_version_	1848881001789390848
author	Rehman, Asia
author_facet	Rehman, Asia
author_sort	Rehman, Asia
building	USM Institutional Repository
collection	Online Access
description	Depletion of estrogen production and secretion in postmenopausal women may lead to rapid bone loss and decreased bone mineral density (BMD). Decreased systemic BMD may also affect oral bone particularly mandibular bone resorption. Although several environmental factors influence bone loss, genetic contribution particularly estrogen receptor gene (ERG) polymorphism had been reported. The objectives of this study were to investigate the distribution of ERG polymorphisms in postmenopausal Malay women (PMW) and to detect the association of the polymorphisms to alveolar bone resorption. Sixty four PMW were recruited from the Out Patient Dental Clinic, Hospital Universiti Sains Malaysia, Kelantan. Oral examination and alveolar bone resorption measurement were performed on these study subjects. Genotyping was done through the restriction cleavage of polymerase chain reactionamplified genomic DNA with the two restriction enzymes, Pvull and Xbal. Estrogen receptor genotypes were represented as P or p (Pvull) and X or x (Xbal) with the lower case letters signifying the presence of the restriction site. The results of this study indicated a high frequency of heterozygous allelic variant (PpXx) in PMW. However no significant association between ERG polymorphisms and alveolar bone resorption was observed. Therefore ERG polymorphisms may not be a genetic marker for the alveolar bone resorption in PMW.
first_indexed	2025-11-15T18:12:05Z
format	Monograph
id	usm-47879
institution	Universiti Sains Malaysia
institution_category	Local University
language	English
last_indexed	2025-11-15T18:12:05Z
publishDate	2006
publisher	Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia
recordtype	eprints
repository_type	Digital Repository
spelling	usm-478792020-11-09T03:30:28Z http://eprints.usm.my/47879/ Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women Rehman, Asia R Medicine Depletion of estrogen production and secretion in postmenopausal women may lead to rapid bone loss and decreased bone mineral density (BMD). Decreased systemic BMD may also affect oral bone particularly mandibular bone resorption. Although several environmental factors influence bone loss, genetic contribution particularly estrogen receptor gene (ERG) polymorphism had been reported. The objectives of this study were to investigate the distribution of ERG polymorphisms in postmenopausal Malay women (PMW) and to detect the association of the polymorphisms to alveolar bone resorption. Sixty four PMW were recruited from the Out Patient Dental Clinic, Hospital Universiti Sains Malaysia, Kelantan. Oral examination and alveolar bone resorption measurement were performed on these study subjects. Genotyping was done through the restriction cleavage of polymerase chain reactionamplified genomic DNA with the two restriction enzymes, Pvull and Xbal. Estrogen receptor genotypes were represented as P or p (Pvull) and X or x (Xbal) with the lower case letters signifying the presence of the restriction site. The results of this study indicated a high frequency of heterozygous allelic variant (PpXx) in PMW. However no significant association between ERG polymorphisms and alveolar bone resorption was observed. Therefore ERG polymorphisms may not be a genetic marker for the alveolar bone resorption in PMW. Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia 2006 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/47879/1/DR.%20ASIA%20REHMAN-Abstract.pdf Rehman, Asia (2006) Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women. Documentation. Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia. (Submitted)
spellingShingle	R Medicine Rehman, Asia Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title	Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title_full	Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title_fullStr	Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title_full_unstemmed	Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title_short	Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title_sort	studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
topic	R Medicine
url	http://eprints.usm.my/47879/ http://eprints.usm.my/47879/1/DR.%20ASIA%20REHMAN-Abstract.pdf

Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women

Similar Items