Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2018
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/47797/ http://eprints.usm.my/47797/1/POTENTIAL%20IMMUNOMODULATING.pdf%20cut.pdf |
| _version_ | 1848880977519050752 |
|---|---|
| author | Kumar, Venugopalan Santhosh |
| author_facet | Kumar, Venugopalan Santhosh |
| author_sort | Kumar, Venugopalan Santhosh |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane,
chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of A. indica leaves (AEAIL) showed significant (P< 0.001) higher immunostimulant activity than other extracts. Hence, isolation of possible phytoconstituent(s) from AEAIL was carried out and the N-Acetylglucosamine (NAG) was isolated. The NAG was administered at 266, 400 and 800 μg/kg of mice, intraperitoneal route weekly for 4 weeks to evaluate immunostimulant activity. |
| first_indexed | 2025-11-15T18:11:42Z |
| format | Thesis |
| id | usm-47797 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:11:42Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-477972020-10-27T09:24:48Z http://eprints.usm.my/47797/ Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice Kumar, Venugopalan Santhosh QR Microbiology Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of A. indica leaves (AEAIL) showed significant (P< 0.001) higher immunostimulant activity than other extracts. Hence, isolation of possible phytoconstituent(s) from AEAIL was carried out and the N-Acetylglucosamine (NAG) was isolated. The NAG was administered at 266, 400 and 800 μg/kg of mice, intraperitoneal route weekly for 4 weeks to evaluate immunostimulant activity. 2018-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/47797/1/POTENTIAL%20IMMUNOMODULATING.pdf%20cut.pdf Kumar, Venugopalan Santhosh (2018) Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | QR Microbiology Kumar, Venugopalan Santhosh Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title | Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title_full | Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title_fullStr | Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title_full_unstemmed | Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title_short | Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice |
| title_sort | potential immunomodulating activity of neem (azadirachta indica) leaf extracts and its bioactive compound n-acetylglucosamine in mice |
| topic | QR Microbiology |
| url | http://eprints.usm.my/47797/ http://eprints.usm.my/47797/1/POTENTIAL%20IMMUNOMODULATING.pdf%20cut.pdf |