Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action
Present study aims to evaluate the antihyperlipidemic effect including possible mechanism, antioxidant capacity and toxicities of extract of P. minus leaves. In acute antihyperlipidemic study, the effect of aqueous and methanol extracts of P. minus leaves (1000 mg/kg) were tested on poloxamer-407 in...
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| Format: | Thesis |
| Language: | English |
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2017
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| Online Access: | http://eprints.usm.my/47652/ http://eprints.usm.my/47652/1/ANTIHYPERLIPIDEMIC%20ACTIVITY.pdf%20cut.pdf |
| _version_ | 1848880936706375680 |
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| author | Varghese, Christapher Parayil |
| author_facet | Varghese, Christapher Parayil |
| author_sort | Varghese, Christapher Parayil |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Present study aims to evaluate the antihyperlipidemic effect including possible mechanism, antioxidant capacity and toxicities of extract of P. minus leaves. In acute antihyperlipidemic study, the effect of aqueous and methanol extracts of P. minus leaves (1000 mg/kg) were tested on poloxamer-407 induced acute hyperlipidemia in rats. Atorvastatin (60 mg/kg) was used as standard drug. The study showed that both extracts reduced the total cholesterol (TC), triglycerides (TG), LDL, VLDL, atherogenic index, and increased HDL levels when compared with hyperlipidemic control and the effect was higher in methanol extract when compared to aqueous extract. |
| first_indexed | 2025-11-15T18:11:03Z |
| format | Thesis |
| id | usm-47652 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:11:03Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-476522020-10-21T07:20:08Z http://eprints.usm.my/47652/ Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action Varghese, Christapher Parayil RS1-441 Pharmacy and materia medica Present study aims to evaluate the antihyperlipidemic effect including possible mechanism, antioxidant capacity and toxicities of extract of P. minus leaves. In acute antihyperlipidemic study, the effect of aqueous and methanol extracts of P. minus leaves (1000 mg/kg) were tested on poloxamer-407 induced acute hyperlipidemia in rats. Atorvastatin (60 mg/kg) was used as standard drug. The study showed that both extracts reduced the total cholesterol (TC), triglycerides (TG), LDL, VLDL, atherogenic index, and increased HDL levels when compared with hyperlipidemic control and the effect was higher in methanol extract when compared to aqueous extract. 2017-09 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/47652/1/ANTIHYPERLIPIDEMIC%20ACTIVITY.pdf%20cut.pdf Varghese, Christapher Parayil (2017) Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Varghese, Christapher Parayil Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action |
| title | Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action |
| title_full | Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action |
| title_fullStr | Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action |
| title_full_unstemmed | Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action |
| title_short | Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action |
| title_sort | antihyperlipidemic activity of polygonum minus and elucidation of its mechanism of action |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/47652/ http://eprints.usm.my/47652/1/ANTIHYPERLIPIDEMIC%20ACTIVITY.pdf%20cut.pdf |