A randomized comparison on the corneal endothelial morphology after the use of 2 different viscoelastic agents during phacoemulsification surgery
Objective: To compare corneal endothelial morphological changes after the use of Healon 5 (sodium hyaluronate 2.3%) and Healon GV (sodium hyaluronate 1.4%) during phacoemulsification surgery, particularly at three months after the surgery. Settings: Department of Ophthalmology, School of Medical...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2006
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| Subjects: | |
| Online Access: | http://eprints.usm.my/46969/ http://eprints.usm.my/46969/1/GP...A%20Randomized%20Comparison%20On%20The%20Corneal%20Endothelial%20Morphology%20After%20The%20Use%20Of%202%20Different%20Viscoelastic%20Agent%20During%20Phacoemulsification%20Surgery...2006...mka..-24%20pages.pdf |
| _version_ | 1848880745584525312 |
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| author | Ismail, Shatriah Ibrahim, Mohtar Ghani, Zulkifli Abd |
| author_facet | Ismail, Shatriah Ibrahim, Mohtar Ghani, Zulkifli Abd |
| author_sort | Ismail, Shatriah |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Objective: To compare corneal endothelial morphological changes after the use of
Healon 5 (sodium hyaluronate 2.3%) and Healon GV (sodium hyaluronate 1.4%) during
phacoemulsification surgery, particularly at three months after the surgery.
Settings: Department of Ophthalmology, School of Medical Sciences, Universiti Sains
Malaysia, Malaysia and Eye clinic, Hospital Kota Bharu, Kelantan, Malaysia.
Materials and Methods: One hundred and ten patients were randomized, 55 per group,
in a prospective randomized clinical trial of phacoemulsification surgery using Heal on 5
or Heal on GV. Three ophthalmologists performed the surgeries. The corneal endothelial
cells density, average cell size, coefficient variation and hexagonality were assessed
preoperatively and at three months postoperatively using a non-contact specular
microscope Topcon SP2000P. Analysis of the data was performed using SPSS version
10.0, Independent-Samples T Test.
Results: There was statistically significant difference between Healon 5 group and
Healon GV group based on endothelial cell density (p=0.015) and percentage of cell loss
(p=0.033). The cell size was noted significantly smaller in the Healon 5 group compared
to the Healon GV group at three months (p=0.004). A similar result was also noted in
percentage of changes in cell size (p=0.033). There were no statistically significant
differences in changes of coefficient variation of cell size and hexagonality in both
groups at three months after the surgery.
Conclusion: Minimal corneal endothelial morphological changes were noted in the
Healon 5 group compared to the Healon GV group, particularly in term of less cell loss
and less alteration in cell size at three months after the surgery. Thus, indicates that
Healon 5 is more effective than Healon GV in minimizing risk of corneal endothelial
injury during phacoemulsification surgery. |
| first_indexed | 2025-11-15T18:08:01Z |
| format | Article |
| id | usm-46969 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:08:01Z |
| publishDate | 2006 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-469692020-08-27T03:12:52Z http://eprints.usm.my/46969/ A randomized comparison on the corneal endothelial morphology after the use of 2 different viscoelastic agents during phacoemulsification surgery Ismail, Shatriah Ibrahim, Mohtar Ghani, Zulkifli Abd RE Ophthalmology Objective: To compare corneal endothelial morphological changes after the use of Healon 5 (sodium hyaluronate 2.3%) and Healon GV (sodium hyaluronate 1.4%) during phacoemulsification surgery, particularly at three months after the surgery. Settings: Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Malaysia and Eye clinic, Hospital Kota Bharu, Kelantan, Malaysia. Materials and Methods: One hundred and ten patients were randomized, 55 per group, in a prospective randomized clinical trial of phacoemulsification surgery using Heal on 5 or Heal on GV. Three ophthalmologists performed the surgeries. The corneal endothelial cells density, average cell size, coefficient variation and hexagonality were assessed preoperatively and at three months postoperatively using a non-contact specular microscope Topcon SP2000P. Analysis of the data was performed using SPSS version 10.0, Independent-Samples T Test. Results: There was statistically significant difference between Healon 5 group and Healon GV group based on endothelial cell density (p=0.015) and percentage of cell loss (p=0.033). The cell size was noted significantly smaller in the Healon 5 group compared to the Healon GV group at three months (p=0.004). A similar result was also noted in percentage of changes in cell size (p=0.033). There were no statistically significant differences in changes of coefficient variation of cell size and hexagonality in both groups at three months after the surgery. Conclusion: Minimal corneal endothelial morphological changes were noted in the Healon 5 group compared to the Healon GV group, particularly in term of less cell loss and less alteration in cell size at three months after the surgery. Thus, indicates that Healon 5 is more effective than Healon GV in minimizing risk of corneal endothelial injury during phacoemulsification surgery. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2006 Article NonPeerReviewed application/pdf en http://eprints.usm.my/46969/1/GP...A%20Randomized%20Comparison%20On%20The%20Corneal%20Endothelial%20Morphology%20After%20The%20Use%20Of%202%20Different%20Viscoelastic%20Agent%20During%20Phacoemulsification%20Surgery...2006...mka..-24%20pages.pdf Ismail, Shatriah and Ibrahim, Mohtar and Ghani, Zulkifli Abd (2006) A randomized comparison on the corneal endothelial morphology after the use of 2 different viscoelastic agents during phacoemulsification surgery. A randomized comparison on the corneal endothelial morphology after the use of 2 different viscoelastic agents during phacoemulsification surgery. (Submitted) |
| spellingShingle | RE Ophthalmology Ismail, Shatriah Ibrahim, Mohtar Ghani, Zulkifli Abd A randomized comparison on the corneal endothelial morphology after the use of 2 different viscoelastic agents during phacoemulsification surgery |
| title | A randomized comparison on the corneal
endothelial morphology after the use of 2
different viscoelastic agents during
phacoemulsification surgery |
| title_full | A randomized comparison on the corneal
endothelial morphology after the use of 2
different viscoelastic agents during
phacoemulsification surgery |
| title_fullStr | A randomized comparison on the corneal
endothelial morphology after the use of 2
different viscoelastic agents during
phacoemulsification surgery |
| title_full_unstemmed | A randomized comparison on the corneal
endothelial morphology after the use of 2
different viscoelastic agents during
phacoemulsification surgery |
| title_short | A randomized comparison on the corneal
endothelial morphology after the use of 2
different viscoelastic agents during
phacoemulsification surgery |
| title_sort | randomized comparison on the corneal
endothelial morphology after the use of 2
different viscoelastic agents during
phacoemulsification surgery |
| topic | RE Ophthalmology |
| url | http://eprints.usm.my/46969/ http://eprints.usm.my/46969/1/GP...A%20Randomized%20Comparison%20On%20The%20Corneal%20Endothelial%20Morphology%20After%20The%20Use%20Of%202%20Different%20Viscoelastic%20Agent%20During%20Phacoemulsification%20Surgery...2006...mka..-24%20pages.pdf |