Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan
Background: There is no optilnmn level or threshold that has been clearly established to define whether there is adequate store of vitamin D in the body for general bone health. Therefore, our study is to determine the optimum level of vitamin D for maintenance of healthy skeleton based on bone remo...
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| Format: | Thesis |
| Language: | English |
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2017
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| Online Access: | http://eprints.usm.my/46901/ http://eprints.usm.my/46901/1/Dr.%20Noor%20Bayani%20Che%20Muda-24%20pages.pdf |
| _version_ | 1848880726993272832 |
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| author | Muda, Noor Bayani Che |
| author_facet | Muda, Noor Bayani Che |
| author_sort | Muda, Noor Bayani Che |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Background: There is no optilnmn level or threshold that has been clearly established to define whether there is adequate store of vitamin D in the body for general bone health. Therefore, our study is to determine the optimum level of vitamin D for maintenance of healthy skeleton based on bone remodelling process. Methods: This was a cross sectional study involving healthy adult population in Kota Bharu, Malaysia, aged 18-50 years. We measured serwn 25(0H)D, serum parathyroid hormone (PTH), serum C-terminal telopeptide of type 1 collagen ( CTX) and Procollagen 1 Intact N-Terminal (P1NP) in 120 healthy adult from 6 sub districts that had been selected by multi stage sampling ( 64 males, 56 females). Results: The mean of vitamin Din this study was 23.50 (±8.74) nmol/L and there was significant difference of vitamin D betvveen gender (26.81±8.3 nmol/L and 19.72±7.68 nmol/L males and females respectively), p value < 0.001. More than 50% of female subjects had vitamin D less than 20 nmol/L, while only 20.3% of male subjects had vitamin D below 20 nmol/L. Based on LOESS plot, the bone turnover markers showed plateau result at vitamin D level of 3 5 nmoi!L for CTX and 20 nmoi/L for p 1 NP. Then, at vitamin D level of 20 nmol/L there is a step decrease of PTH level. Conclusion: The mean of vitamin D among general healthy population in Kota Bharu was 23.50nmoi/L. Based on inspection of LOESS plot for CTX, PlNP and PTH versusvitamin D level, we concluded that vitamin D level between 20 nmol/L to 35 nmol/L is considered sufficient to maintain healthy skeleton. |
| first_indexed | 2025-11-15T18:07:43Z |
| format | Thesis |
| id | usm-46901 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:07:43Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-469012020-08-18T07:13:50Z http://eprints.usm.my/46901/ Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan Muda, Noor Bayani Che RC Internal medicine Background: There is no optilnmn level or threshold that has been clearly established to define whether there is adequate store of vitamin D in the body for general bone health. Therefore, our study is to determine the optimum level of vitamin D for maintenance of healthy skeleton based on bone remodelling process. Methods: This was a cross sectional study involving healthy adult population in Kota Bharu, Malaysia, aged 18-50 years. We measured serwn 25(0H)D, serum parathyroid hormone (PTH), serum C-terminal telopeptide of type 1 collagen ( CTX) and Procollagen 1 Intact N-Terminal (P1NP) in 120 healthy adult from 6 sub districts that had been selected by multi stage sampling ( 64 males, 56 females). Results: The mean of vitamin Din this study was 23.50 (±8.74) nmol/L and there was significant difference of vitamin D betvveen gender (26.81±8.3 nmol/L and 19.72±7.68 nmol/L males and females respectively), p value < 0.001. More than 50% of female subjects had vitamin D less than 20 nmol/L, while only 20.3% of male subjects had vitamin D below 20 nmol/L. Based on LOESS plot, the bone turnover markers showed plateau result at vitamin D level of 3 5 nmoi!L for CTX and 20 nmoi/L for p 1 NP. Then, at vitamin D level of 20 nmol/L there is a step decrease of PTH level. Conclusion: The mean of vitamin D among general healthy population in Kota Bharu was 23.50nmoi/L. Based on inspection of LOESS plot for CTX, PlNP and PTH versusvitamin D level, we concluded that vitamin D level between 20 nmol/L to 35 nmol/L is considered sufficient to maintain healthy skeleton. 2017 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/46901/1/Dr.%20Noor%20Bayani%20Che%20Muda-24%20pages.pdf Muda, Noor Bayani Che (2017) Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RC Internal medicine Muda, Noor Bayani Che Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan |
| title | Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan |
| title_full | Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan |
| title_fullStr | Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan |
| title_full_unstemmed | Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan |
| title_short | Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan |
| title_sort | study on vitamin d status and determination of optimum vitamin d level based on bone turnover markers in kota bharu, kelantan |
| topic | RC Internal medicine |
| url | http://eprints.usm.my/46901/ http://eprints.usm.my/46901/1/Dr.%20Noor%20Bayani%20Che%20Muda-24%20pages.pdf |