Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of randomized control trials
Erectile dysfunction is common in adult men, particularly those with hypertension and diabetes. The present study determines the effectiveness of angiotensin receptor blocker (ARB) drugs on erectile function in hypertensive male adults. For this purpose, CENTRAL and MEDLINE and reference lists of...
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| Format: | Article |
| Language: | English |
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Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2019
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| Online Access: | http://eprints.usm.my/45865/ http://eprints.usm.my/45865/1/Angiotensin-%20ED%20AMJ%202019-OCR.pdf |
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| author | Ismail, Shaiful Bahari Noor, Norhayati Mohd Hussain, Nik Hazlina Nik Sulaiman, Zaharah Shamsudin, Muhammad Asyraf Irfan, Muhammad |
| author_facet | Ismail, Shaiful Bahari Noor, Norhayati Mohd Hussain, Nik Hazlina Nik Sulaiman, Zaharah Shamsudin, Muhammad Asyraf Irfan, Muhammad |
| author_sort | Ismail, Shaiful Bahari |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Erectile dysfunction is common in adult men, particularly those with hypertension and diabetes. The present study
determines the effectiveness of angiotensin receptor blocker (ARB) drugs on erectile function in hypertensive male
adults. For this purpose, CENTRAL and MEDLINE and reference lists of the articles were searched. The randomized
controlled trials (RCTs) were selected that compared ARBs with conventional therapy or no treatment in men of any
ethnicity who were presented with hypertension and/or diabetes. A total four trials that had 2,809 men were included.
Three trials reported adequate random sequence allocation, two reported adequate blinding. Attrition bias is low in
one of the included studies. All three studies are of low risk of selective reporting bias. There was an improvement in
sexual activity with ARBs (valsartan) (mean difference (MD): 0.71, 95% Confidence Interval (CI) 0.66 to 0.76, I2 statistic
= 0%). However, the erectile functions did not increase significantly in ARBs (losartan or telmisartan) treated men as
compared to control or placebo (n = 203 vs n = 232; MD: 1.36; 95% CI: −0.97 to −3.69; I2 statistic = 80%). These
results suggested that ARBs significantly improved sexual activity among hypertensive men. However, the erectile
function was not significantly improved in ARBs treated men as compared to the control or placebo-treated. There
were limited studies available. Hence, additional studies are needed to support findings from this review. ARBs should
be considered when prescribing antihypertensive drugs to men. |
| first_indexed | 2025-11-15T18:03:16Z |
| format | Article |
| id | usm-45865 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:03:16Z |
| publishDate | 2019 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-458652019-12-23T04:30:24Z http://eprints.usm.my/45865/ Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of randomized control trials Ismail, Shaiful Bahari Noor, Norhayati Mohd Hussain, Nik Hazlina Nik Sulaiman, Zaharah Shamsudin, Muhammad Asyraf Irfan, Muhammad RC Internal medicine Erectile dysfunction is common in adult men, particularly those with hypertension and diabetes. The present study determines the effectiveness of angiotensin receptor blocker (ARB) drugs on erectile function in hypertensive male adults. For this purpose, CENTRAL and MEDLINE and reference lists of the articles were searched. The randomized controlled trials (RCTs) were selected that compared ARBs with conventional therapy or no treatment in men of any ethnicity who were presented with hypertension and/or diabetes. A total four trials that had 2,809 men were included. Three trials reported adequate random sequence allocation, two reported adequate blinding. Attrition bias is low in one of the included studies. All three studies are of low risk of selective reporting bias. There was an improvement in sexual activity with ARBs (valsartan) (mean difference (MD): 0.71, 95% Confidence Interval (CI) 0.66 to 0.76, I2 statistic = 0%). However, the erectile functions did not increase significantly in ARBs (losartan or telmisartan) treated men as compared to control or placebo (n = 203 vs n = 232; MD: 1.36; 95% CI: −0.97 to −3.69; I2 statistic = 80%). These results suggested that ARBs significantly improved sexual activity among hypertensive men. However, the erectile function was not significantly improved in ARBs treated men as compared to the control or placebo-treated. There were limited studies available. Hence, additional studies are needed to support findings from this review. ARBs should be considered when prescribing antihypertensive drugs to men. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2019-11 Article NonPeerReviewed application/pdf en http://eprints.usm.my/45865/1/Angiotensin-%20ED%20AMJ%202019-OCR.pdf Ismail, Shaiful Bahari and Noor, Norhayati Mohd and Hussain, Nik Hazlina Nik and Sulaiman, Zaharah and Shamsudin, Muhammad Asyraf and Irfan, Muhammad (2019) Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of randomized control trials. Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of randomized control trials. (Submitted) |
| spellingShingle | RC Internal medicine Ismail, Shaiful Bahari Noor, Norhayati Mohd Hussain, Nik Hazlina Nik Sulaiman, Zaharah Shamsudin, Muhammad Asyraf Irfan, Muhammad Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of randomized control trials |
| title | Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of
randomized control trials |
| title_full | Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of
randomized control trials |
| title_fullStr | Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of
randomized control trials |
| title_full_unstemmed | Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of
randomized control trials |
| title_short | Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of
randomized control trials |
| title_sort | angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of
randomized control trials |
| topic | RC Internal medicine |
| url | http://eprints.usm.my/45865/ http://eprints.usm.my/45865/1/Angiotensin-%20ED%20AMJ%202019-OCR.pdf |