Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein
Antigen recognition by T cell receptor (TCR) induces intracellular signaling cascades leading to T cell activation, subsequently inducing cellular proliferation and various effector functions. Adaptor proteins play important roles in T cell signaling by creating nodes to recruit signaling proteins a...
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| Format: | Thesis |
| Language: | English |
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2017
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| Online Access: | http://eprints.usm.my/45399/ http://eprints.usm.my/45399/1/KONG%20MEI%20SUEN.pdf |
| _version_ | 1848880320371228672 |
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| author | Kong, Mei Suen |
| author_facet | Kong, Mei Suen |
| author_sort | Kong, Mei Suen |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Antigen recognition by T cell receptor (TCR) induces intracellular signaling cascades leading to T cell activation, subsequently inducing cellular proliferation and various effector functions. Adaptor proteins play important roles in T cell signaling by creating nodes to recruit signaling proteins and form signal complexes to regulate the direction of signaling. Casitas B-lineage lymphoma (Cbl)-interacting protein of 85 kDa (CIN85) is an adaptor protein, originally identified as a Cbl-binding protein, and was suggested to be involved in the internalization and degradation of receptors and kinases. Nevertheless, the physiological function of CIN85 in T cells is unknown. |
| first_indexed | 2025-11-15T18:01:15Z |
| format | Thesis |
| id | usm-45399 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:01:15Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-453992019-09-12T01:39:18Z http://eprints.usm.my/45399/ Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein Kong, Mei Suen RS1-441 Pharmacy and materia medica Antigen recognition by T cell receptor (TCR) induces intracellular signaling cascades leading to T cell activation, subsequently inducing cellular proliferation and various effector functions. Adaptor proteins play important roles in T cell signaling by creating nodes to recruit signaling proteins and form signal complexes to regulate the direction of signaling. Casitas B-lineage lymphoma (Cbl)-interacting protein of 85 kDa (CIN85) is an adaptor protein, originally identified as a Cbl-binding protein, and was suggested to be involved in the internalization and degradation of receptors and kinases. Nevertheless, the physiological function of CIN85 in T cells is unknown. 2017-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/45399/1/KONG%20MEI%20SUEN.pdf Kong, Mei Suen (2017) Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Kong, Mei Suen Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title | Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title_full | Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title_fullStr | Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title_full_unstemmed | Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title_short | Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title_sort | negative regulation of t cell activation and function by cin85 adaptor protein |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/45399/ http://eprints.usm.my/45399/1/KONG%20MEI%20SUEN.pdf |