Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress
The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressinduced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memo...
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| Format: | Article |
| Language: | English |
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Taibah University, Madinah, Kingdom of Saudi Arabia
2018
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| Online Access: | http://eprints.usm.my/45338/ http://eprints.usm.my/45338/1/Neuroprotective%20effects%20of%20Tualang%20honey.pdf |
| _version_ | 1848880301761101824 |
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| author | Azman, Khairunnuur Fairuz Zakaria, Rahimah Othman, Zahiruddin Aziz, Che Badariah Abdul |
| author_facet | Azman, Khairunnuur Fairuz Zakaria, Rahimah Othman, Zahiruddin Aziz, Che Badariah Abdul |
| author_sort | Azman, Khairunnuur Fairuz |
| building | USM Institutional Repository |
| collection | Online Access |
| description | The neuroprotective effects of Tualang honey in stress-induced young and aged rats were
investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressinduced
rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress
exposure significantly induced memory impairment, increased brain oxidation indices, and
decreased antioxidant enzymes activities and neuronal density in mPFC, CA2 and CA3
hippocampal areas in both young and aged rats. The stressed rats treated with Tualang
honey showed a significant decrease in stress hormone levels and brain oxidation indices,
and increase in memory, antioxidant enzymes activities, and neuronal density in mPFC and
hippocampus compared to the vehicle-treated stressed rats. The protective effect of Tualang
honey was more prominent in young than aged rats. These results suggest the
neuroprotective effects of Tualang honey against oxidative stress and memory decline due
to stress exposure and/or ageing through its antioxidant property. |
| first_indexed | 2025-11-15T18:00:57Z |
| format | Article |
| id | usm-45338 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:00:57Z |
| publishDate | 2018 |
| publisher | Taibah University, Madinah, Kingdom of Saudi Arabia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-453382019-09-06T09:02:29Z http://eprints.usm.my/45338/ Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress Azman, Khairunnuur Fairuz Zakaria, Rahimah Othman, Zahiruddin Aziz, Che Badariah Abdul RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressinduced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memory impairment, increased brain oxidation indices, and decreased antioxidant enzymes activities and neuronal density in mPFC, CA2 and CA3 hippocampal areas in both young and aged rats. The stressed rats treated with Tualang honey showed a significant decrease in stress hormone levels and brain oxidation indices, and increase in memory, antioxidant enzymes activities, and neuronal density in mPFC and hippocampus compared to the vehicle-treated stressed rats. The protective effect of Tualang honey was more prominent in young than aged rats. These results suggest the neuroprotective effects of Tualang honey against oxidative stress and memory decline due to stress exposure and/or ageing through its antioxidant property. Taibah University, Madinah, Kingdom of Saudi Arabia 2018 Article PeerReviewed application/pdf en http://eprints.usm.my/45338/1/Neuroprotective%20effects%20of%20Tualang%20honey.pdf Azman, Khairunnuur Fairuz and Zakaria, Rahimah and Othman, Zahiruddin and Aziz, Che Badariah Abdul (2018) Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress. Journal of Taibah University for Science, 12 (3). pp. 1-12. ISSN 1658-3655 https://www.tandfonline.com/doi/full/10.1080/16583655.2018.1465275 |
| spellingShingle | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Azman, Khairunnuur Fairuz Zakaria, Rahimah Othman, Zahiruddin Aziz, Che Badariah Abdul Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress |
| title | Neuroprotective effects of Tualang honey against
oxidative stress and memory decline in young and
aged rats exposed to noise stress |
| title_full | Neuroprotective effects of Tualang honey against
oxidative stress and memory decline in young and
aged rats exposed to noise stress |
| title_fullStr | Neuroprotective effects of Tualang honey against
oxidative stress and memory decline in young and
aged rats exposed to noise stress |
| title_full_unstemmed | Neuroprotective effects of Tualang honey against
oxidative stress and memory decline in young and
aged rats exposed to noise stress |
| title_short | Neuroprotective effects of Tualang honey against
oxidative stress and memory decline in young and
aged rats exposed to noise stress |
| title_sort | neuroprotective effects of tualang honey against
oxidative stress and memory decline in young and
aged rats exposed to noise stress |
| topic | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| url | http://eprints.usm.my/45338/ http://eprints.usm.my/45338/ http://eprints.usm.my/45338/1/Neuroprotective%20effects%20of%20Tualang%20honey.pdf |