Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats
Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying mechanisms involved.This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress. T...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2016
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| Online Access: | http://eprints.usm.my/45334/ http://eprints.usm.my/45334/1/OMCL2016%20-%20TH.pdf |
| _version_ | 1848880300581453824 |
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| author | Azman, Khairunnuur Fairuz Zakaria, Rahimah Aziz, Che Badariah Abdul Othman, Zahiruddin |
| author_facet | Azman, Khairunnuur Fairuz Zakaria, Rahimah Aziz, Che Badariah Abdul Othman, Zahiruddin |
| author_sort | Azman, Khairunnuur Fairuz |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying
mechanisms involved.This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory
performance in aged rats exposed to noise stress. Tualang honey supplementation was given orally, 200mg/kg body weight for 28
days. Rats in the stress groupwere subjected to loud noise, 100 dB(A), 4 hours daily for 14 days.All ratswere subjected to novel object
recognition test for evaluation of memory performance. It was observed that the rats subjected to noise stress exhibited significantly
lower memory performance and higher oxidative stress as evident by elevated malondialdehyde and protein carbonyl levels and
reduction of antioxidant enzymes activities compared to the nonstressed rats. Tualang honey supplementation was able to improve
memory performance, decrease oxidative stress levels, increase brain-derived neurotrophic factor (BDNF) concentration, decrease
acetylcholinesterase activity, and enhance neuronal proliferation in the medial prefrontal cortex (mPFC) and hippocampus. In
conclusion, Tualang honey protects against memory decline due to stress exposure and/or ageing via enhancement of mPFC and
hippocampal morphology possibly secondary to reduction in brain oxidative stress and/or upregulation of BDNF concentration
and cholinergic system. |
| first_indexed | 2025-11-15T18:00:56Z |
| format | Article |
| id | usm-45334 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T18:00:56Z |
| publishDate | 2016 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-453342019-09-06T07:49:16Z http://eprints.usm.my/45334/ Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats Azman, Khairunnuur Fairuz Zakaria, Rahimah Aziz, Che Badariah Abdul Othman, Zahiruddin RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Ageing and stress exposure may lead to memory impairment while oxidative stress is thought to be one of the underlying mechanisms involved.This study aimed to investigate the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress. Tualang honey supplementation was given orally, 200mg/kg body weight for 28 days. Rats in the stress groupwere subjected to loud noise, 100 dB(A), 4 hours daily for 14 days.All ratswere subjected to novel object recognition test for evaluation of memory performance. It was observed that the rats subjected to noise stress exhibited significantly lower memory performance and higher oxidative stress as evident by elevated malondialdehyde and protein carbonyl levels and reduction of antioxidant enzymes activities compared to the nonstressed rats. Tualang honey supplementation was able to improve memory performance, decrease oxidative stress levels, increase brain-derived neurotrophic factor (BDNF) concentration, decrease acetylcholinesterase activity, and enhance neuronal proliferation in the medial prefrontal cortex (mPFC) and hippocampus. In conclusion, Tualang honey protects against memory decline due to stress exposure and/or ageing via enhancement of mPFC and hippocampal morphology possibly secondary to reduction in brain oxidative stress and/or upregulation of BDNF concentration and cholinergic system. Hindawi Publishing Corporation 2016 Article PeerReviewed application/pdf en http://eprints.usm.my/45334/1/OMCL2016%20-%20TH.pdf Azman, Khairunnuur Fairuz and Zakaria, Rahimah and Aziz, Che Badariah Abdul and Othman, Zahiruddin (2016) Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats. Oxidative Medicine and Cellular Longevity, 2016 (154915). pp. 1-11. ISSN 1942-0900 http://dx.doi.org/10.1155/2016/1549158 |
| spellingShingle | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Azman, Khairunnuur Fairuz Zakaria, Rahimah Aziz, Che Badariah Abdul Othman, Zahiruddin Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats |
| title | Tualang Honey Attenuates Noise Stress-Induced
Memory Deficits in Aged Rats |
| title_full | Tualang Honey Attenuates Noise Stress-Induced
Memory Deficits in Aged Rats |
| title_fullStr | Tualang Honey Attenuates Noise Stress-Induced
Memory Deficits in Aged Rats |
| title_full_unstemmed | Tualang Honey Attenuates Noise Stress-Induced
Memory Deficits in Aged Rats |
| title_short | Tualang Honey Attenuates Noise Stress-Induced
Memory Deficits in Aged Rats |
| title_sort | tualang honey attenuates noise stress-induced
memory deficits in aged rats |
| topic | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| url | http://eprints.usm.my/45334/ http://eprints.usm.my/45334/ http://eprints.usm.my/45334/1/OMCL2016%20-%20TH.pdf |